Aceclofenac & paracetamol tablets uses in hindi

Identification Generic Name Aceclofenac DrugBank Accession Number DB06736 Background Aceclofenac is an oral non-steroidal anti-inflammatory drug (NSAID) with marked anti-inflammatory and analgesic properties used to treat osteoarthritis, rheumatoid arthritis and ankylosing spondylitis. It is reported to have a higher anti-inflammatory action or at least comparable effects than conventional NSAIDs in double-blind studies Type Small Molecule Groups Approved, Investigational Structure Close Weight Average: 354.18 Monoisotopic: 353.0221633 Chemical Formula C 16H 13Cl 2NO 4 Synonyms • 2-[(2,6-dichlorophenyl)amino]benzeneacetic acid carboxymethyl ester • 2-[(2,6-dichlorophenyl)amino]phenylacetoxyacetic acid • 2-[(2',6'-dichlorophenyl)amino]phenylacetoxyacetic acid • Aceclofenac • Acéclofénac Learn more Pharmacodynamics Aceclofenac is a NSAID that inhibits both isoforms of COX enzyme, a key enzyme involved in the inflammatory cascade. COX-1 enzyme is a constitutive enzyme involved in prostacyclin production and protective functions of gastric mucosa whereas COX-2 is an inducible enzyme involved in the production of inflammatory mediators in response to inflammatory stimuli. Aceclofenac displays more selectivity towards COX-2 (IC50 of 0.77uM) than COX-1 (IC50 of >100uM), which promotes its gastric tolerance compared to other NSAIDs. The primary metabolite, 4'-hydroxyaceclofenac, also minimally inhibits COX-2 with IC50 value of 36uM Mechanism of action Through COX-2 inhibition, ace...

PACKAGE LEAFLET: INFORMATION FOR THE USER PRESERVEX™ 100MG TABLETS (aceclofenac) Your medicine is available using the name Preservex 100mg Tablets but will be referred to as Preservex throughout this leaflet. Read all of this leaflet carefully before you start taking this medicine because it contains important information for you.     Keep this leaflet. You may need to read it again. If you have any further questions, ask your doctor, pharmacist or nurse. This medicine has been prescribed for you only. Do not pass it on to others. It may harm them, even if their signs of illness are the same as yours. If you get any side effects talk to your doctor, pharmacist or nurse. This includes any possible side effects not listed in this leaflet. See also section 4. What is in this leaflet: 1. 2. 3. 4. 5. 6. What Preservex is and what it is used for What you need to know before you take Preservex How to take Preservex Possible side effects How to store Preservex Contents of the pack and other information 1. What Preservex is and what it is used for Preservex belongs to a group of medicines called nonsteroidal anti-inflammatory drugs (NSAIDs). These drugs have anti-inflammatory and painkiller properties. The active ingredient of Preservex is aceclofenac. Preservex works by blocking the production of hormone-like substances called prostaglandins. Prostaglandins are released at the sites of injury, tissue damage and immune reactions. Prostaglandins play an important role in both th...

Aceclofenac is a medicine called a non-steroidal anti-inflammatory drug. It is also known as 'an NSAID'. Before you take aceclofenac, tell your doctor if you have ever had an allergic reaction to any other anti-inflammatory painkiller. Take one tablet in the morning and one in the evening. Take the tablets during a meal, or after a snack. Aceclofenac tablets for pain and inflammation Preservex In this article • What is aceclofenac? • Before taking aceclofenac • How to take aceclofenac • Getting the most from your aceclofenac treatment • Can aceclofenac cause problems? • How to store aceclofenac • Important information about all medicines Type of medicine A non-steroidal anti-inflammatory drug (NSAID) Used for Relief of pain and inflammation in adults with arthritis or ankylosing spondylitis Also called Preservex® Available as Tablets Aceclofenac works by blocking the effect of natural substances called cyclo-oxygenase (COX) enzymes. These enzymes help to make other chemicals in the body, called prostaglandins. Some prostaglandins are produced at sites of injury or damage, and cause pain and inflammation. By blocking the effect of COX enzymes, fewer prostaglandins are produced, which means pain and inflammation are eased. Before taking aceclofenac Some medicines are not suitable for people with certain conditions, and sometimes a medicine can only be used if extra care is taken. For these reasons, before you start taking aceclofenac, it is important that your doctor knows: ...

Key:MNIPYSSQXLZQLJ-UHFFFAOYSA-N Y N Y Aceclofenac is a It was patented in 1983 and approved for medical use in 1992. Side effects [ ] Aceclofenac should not be given to people with Chemistry [ ] Aceclofenac (C 16H 13Cl 2NO 4), chemically [(2- phenylacetooxyacetic acid], is a crystalline powder with a molecular weight of 354.19. It is practically insoluble in water with good permeability. It is metabolized in human hepatocytes and human microsomes to form [2-(2',6'-dichloro-4'-hydroxy- phenylamino) phenyl] acetoxyacetic acid as the major metabolite, which is then further conjugated. According to the Biopharmaceutical Classification System (BCS) drug substances are classified to four classes upon their solubility and permeability. Aceclofenac falls under the BCS Class II, poorly soluble and highly permeable drug. Aceclofenac works by inhibiting the action of cyclooxygenase (COX) that is involved in the production of prostaglandins (PG) which is accountable for pain, swelling, inflammation and fever. The incidence of gastric ulcerogenicity of aceclofenac has been reported to be significantly lower than that of the other frequently prescribed NSAIDs, for instance, 2-folds lesser than naproxen, 4-folds lesser than Society and culture [ ] Economics [ ] Aceclofenac is available in Brand names [ ] Aceclofenac is available in Europe and References [ ] Citations [ ] • Drugs.com. 2 November 2020 . Retrieved 4 December 2020. • DailyMed. 2 November 2011 . Retrieved 4 December 2020. • (...

Take it as per the dose and duration prescribed by your doctor. Long term use may lead to serious complications such as stomach bleeding and kidney problems. • It may cause dizziness, drowsiness or visual disturbances. Use caution while driving or doing anything that requires concentration. • Avoid consuming alcohol while taking Aceclofenac as it can cause excessive drowsiness and increase your risk of stomach problems. • Inform your doctor if you have a history of heart disease or stroke. • Your doctor may regularly monitor your kidney function, liver function and levels of blood components, if you are taking this medicine for long-term treatment. Q. Can Aceclofenac hurt your kidneys? Long-term use and high doses of Aceclofenac may cause renal problems, such as protein or blood in urine and pain during urination. Patients who had or have heart failure, impaired kidney function and hypertension are at risk of kidney problems. The risk of developing kidney problems is also high in patients who are on medicines which cause excess urination (diuretics), or medicines which have significant impact on kidney function. Along with that, Aceclofenac can affect kidneys of patients who are above 65 years of age or who remain dehydrated. Therefore, kidney function monitoring is recommended for such patients. Q. What if I forget to take a dose of Aceclofenac? If you forget a dose of Aceclofenac, take it as soon as you remember. However, if it is almost time for your next dose, skip the...

Aceclofenac Aceclofenac belongs to the category of non-steroidal anti-inflammatory drugs (NSAIDs). This medicine is prescribed in cases of chronic inflammation and pain in the What are the uses of Aceclofenac? The anti-inflammatory and palliative properties of Aceclofenac are particularly helpful for people with certain diseases, someAceclofenac uses are • Rheumatoid Arthritis: Aceclofenac helps relieve symptoms like swelling and stiffness of the joints as well as chronic pain that may occur all over the body. • Ankylosing Spondylitis: This condition leads to pain and stiffness that can be managed by Aceclofenac. • Osteoarthritis: Aceclofenac helps relieve tender, painful joints and alleviate pain in cases of osteoarthritis. How and when to take Aceclofenac? • Aceclofenac is available in the form of tablets that are to be taken orally. Before you start consuming it, go through the printed information leaflet, which will provide you with more information about the medicine. • Take the dose as prescribed by your doctor. Usually, it is prescribed to take one 100 mg tablet twice daily. The dosage can be taken once in the morning and then in the evening, preferably. • It is suggested that you take Aceclofenac during, after a meal, or with milk. This will help avoid side effects like stomach irritation or indigestion. • The tablet should be swallowed with water but should not be crushed or chewed. What are the side effects of Aceclofenac? Certain common Aceclofenac side effects ...

PACKAGE LEAFLET: INFORMATION FOR THE USER PRESERVEX™ 100MG TABLETS (aceclofenac) Your medicine is available using the name Preservex 100mg Tablets but will be referred to as Preservex throughout this leaflet. Read all of this leaflet carefully before you start taking this medicine because it contains important information for you.     Keep this leaflet. You may need to read it again. If you have any further questions, ask your doctor, pharmacist or nurse. This medicine has been prescribed for you only. Do not pass it on to others. It may harm them, even if their signs of illness are the same as yours. If you get any side effects talk to your doctor, pharmacist or nurse. This includes any possible side effects not listed in this leaflet. See also section 4. What is in this leaflet: 1. 2. 3. 4. 5. 6. What Preservex is and what it is used for What you need to know before you take Preservex How to take Preservex Possible side effects How to store Preservex Contents of the pack and other information 1. What Preservex is and what it is used for Preservex belongs to a group of medicines called nonsteroidal anti-inflammatory drugs (NSAIDs). These drugs have anti-inflammatory and painkiller properties. The active ingredient of Preservex is aceclofenac. Preservex works by blocking the production of hormone-like substances called prostaglandins. Prostaglandins are released at the sites of injury, tissue damage and immune reactions. Prostaglandins play an important role in both th...

Take it as per the dose and duration prescribed by your doctor. Long term use may lead to serious complications such as stomach bleeding and kidney problems. • It may cause dizziness, drowsiness or visual disturbances. Use caution while driving or doing anything that requires concentration. • Avoid consuming alcohol while taking Aceclofenac as it can cause excessive drowsiness and increase your risk of stomach problems. • Inform your doctor if you have a history of heart disease or stroke. • Your doctor may regularly monitor your kidney function, liver function and levels of blood components, if you are taking this medicine for long-term treatment. Q. Can Aceclofenac hurt your kidneys? Long-term use and high doses of Aceclofenac may cause renal problems, such as protein or blood in urine and pain during urination. Patients who had or have heart failure, impaired kidney function and hypertension are at risk of kidney problems. The risk of developing kidney problems is also high in patients who are on medicines which cause excess urination (diuretics), or medicines which have significant impact on kidney function. Along with that, Aceclofenac can affect kidneys of patients who are above 65 years of age or who remain dehydrated. Therefore, kidney function monitoring is recommended for such patients. Q. What if I forget to take a dose of Aceclofenac? If you forget a dose of Aceclofenac, take it as soon as you remember. However, if it is almost time for your next dose, skip the...

Identification Generic Name Aceclofenac DrugBank Accession Number DB06736 Background Aceclofenac is an oral non-steroidal anti-inflammatory drug (NSAID) with marked anti-inflammatory and analgesic properties used to treat osteoarthritis, rheumatoid arthritis and ankylosing spondylitis. It is reported to have a higher anti-inflammatory action or at least comparable effects than conventional NSAIDs in double-blind studies Type Small Molecule Groups Approved, Investigational Structure Close Weight Average: 354.18 Monoisotopic: 353.0221633 Chemical Formula C 16H 13Cl 2NO 4 Synonyms • 2-[(2,6-dichlorophenyl)amino]benzeneacetic acid carboxymethyl ester • 2-[(2,6-dichlorophenyl)amino]phenylacetoxyacetic acid • 2-[(2',6'-dichlorophenyl)amino]phenylacetoxyacetic acid • Aceclofenac • Acéclofénac Learn more Pharmacodynamics Aceclofenac is a NSAID that inhibits both isoforms of COX enzyme, a key enzyme involved in the inflammatory cascade. COX-1 enzyme is a constitutive enzyme involved in prostacyclin production and protective functions of gastric mucosa whereas COX-2 is an inducible enzyme involved in the production of inflammatory mediators in response to inflammatory stimuli. Aceclofenac displays more selectivity towards COX-2 (IC50 of 0.77uM) than COX-1 (IC50 of >100uM), which promotes its gastric tolerance compared to other NSAIDs. The primary metabolite, 4'-hydroxyaceclofenac, also minimally inhibits COX-2 with IC50 value of 36uM Mechanism of action Through COX-2 inhibition, ace...

Key:MNIPYSSQXLZQLJ-UHFFFAOYSA-N Y N Y Aceclofenac is a It was patented in 1983 and approved for medical use in 1992. Side effects [ ] Aceclofenac should not be given to people with Chemistry [ ] Aceclofenac (C 16H 13Cl 2NO 4), chemically [(2- phenylacetooxyacetic acid], is a crystalline powder with a molecular weight of 354.19. It is practically insoluble in water with good permeability. It is metabolized in human hepatocytes and human microsomes to form [2-(2',6'-dichloro-4'-hydroxy- phenylamino) phenyl] acetoxyacetic acid as the major metabolite, which is then further conjugated. According to the Biopharmaceutical Classification System (BCS) drug substances are classified to four classes upon their solubility and permeability. Aceclofenac falls under the BCS Class II, poorly soluble and highly permeable drug. Aceclofenac works by inhibiting the action of cyclooxygenase (COX) that is involved in the production of prostaglandins (PG) which is accountable for pain, swelling, inflammation and fever. The incidence of gastric ulcerogenicity of aceclofenac has been reported to be significantly lower than that of the other frequently prescribed NSAIDs, for instance, 2-folds lesser than naproxen, 4-folds lesser than Society and culture [ ] Economics [ ] Aceclofenac is available in Brand names [ ] Aceclofenac is available in Europe and References [ ] Citations [ ] • Drugs.com. 2 November 2020 . Retrieved 4 December 2020. • DailyMed. 2 November 2011 . Retrieved 4 December 2020. • (...