Anti endomysial antibody

The anti-endomysial antibody test (EMAIgA), EMA-IgA, is very specific for celiac disease. It’s estimated that a person with an elevated titer of EMA is almost assured of having celiac disease. However, the EMA test isn’t as sensitive as the tTG-IgA test; about 5-10% of celiacs do not have a positive EMA test. May, 2013

I have noticed throughout my research and speaking to doctors that the endomysial antibody is "a thin connective tissue layer that covers individual muscle fibers. Anti-Endomysial antibodies are developed in reaction to the ongoing damage to the intestinal lining." - Open Original Shared Link Ok, so it is created in damage to the small intestinal villi and there are several causes of such damage, here are some of the many: Coeliac Disease Cows Milk Protein Intolerance Soy Protein Intolerance refractory Sprue collagenous Sprue Immunodefiency Synodromes Mediterranean lymphoma intestinal ulceration Gastroenteritis Intractable Diarrhoea of Infancy Protein Calorie Malnutrition Kwashiorkor Tropical Sprue Parasitic Disease: Giardiasis Strongyloidiasis Coccidiosis Intestinal Capillariasis Hookworm Disease Eosinophilic Gastroenteritis Contaminated bowel Syndrome Drug and Radiation Damage Understanding this, why would the endomysial antibody have a 95 percent specificity? Some even say it is closer to 100 but it seems most of the causes of intestinal damage can be much more common than celiacs. In my opinion if TTG and EMA only assess damage than there should be a high reliability on other antibody's that are specific to gluten reactions to make sure it is not coming from something else. Should the DGP not be the one that is close to 100 percent specific? Another scary thing- EMA is elevated in intestinal lymphoma, that is why I feel it is so necessary to have a biopsy. What do you ...

3 - 5 days Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary. Celiac disease is a gluten enteropathy occurring in both children and adults. The disease is probably underdiagnosed in that it may affect as much as 1% of the population in the US. The condition is characterized by a sensitivity to gluten (found in wheat, barley, and rye) that causes inflammation and atrophy of the villi of the small intestine, malabsorption, etc. This sensitivity to gluten may also be seen in dermatitis herpetiformis. Strict avoidance of gluten in the diet will control disease activity, and antibodies to serum markers will disappear with time. Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC 165126 Celiac Disease Comprehensive 94493-4 161652 Deamidated Gliadin Abs, IgA units 58709-7 165126 Celiac Disease Comprehensive 94493-4 161693 Deamidated Gliadin Abs, IgG units 58710-5 165126 Celiac Disease Comprehensive 94493-4 164643 t-Transglutaminase (tTG) IgA U/mL 31017-7 165126 Celiac Disease Comprehensive 94493-4 164989 t-Transglutaminase (tTG) IgG U/mL 32998-7 165126 Celiac Disease Comprehensive 94493-4 164997 Endomysial Antibody IgA 10362-2 165126 Celiac Disease Comprehensive 94493-4 001784 Immunoglobulin A, Qn, Serum mg...

Gliadin Antibodies IgA Gliadin Antibodies and Celiac disease Sample for Gliadin Antibodies IgA • Collect the venous blood to prepare the serum. • A fasting sample is not necessary. • An intestinal biopsy may be advised, and it gives characteristic changes. Purpose of the test (Indications) for Gliadin Antibodies IgA • These antibodies are detected in gluten-sensitive enteropathy. • This test is done to diagnose Celiac disease and sprue. • These antibodies are done to monitor the disease. • In successful treatment with a gluten-free diet, these antibodies will disappear from the serum. Precautions for Gliadin Antibodies IgA • Other gastrointestinal diseases like colitis, Crohn’s disease, and lactose intolerance can raise Gliadin antibodies’ values. • Get the list of foods eaten in the last 24 hours. Definition of Celiac disease/Sprue • It is also called Celiac disease, Gluten-sensitivity enteropathy, nontropical sprue, or idiopathic steatorrhea. • Gluten-induced enteropathy includes Sprue and Celiac disease. • Both these diseases involved duodenum and jejunum predominantly. • The celiac disease sometimes is called non-tropical sprue, celiac sprue, or gluten-sensitive enteropathy. • Celiac disease is an autoimmune multisystem disease. • Celiac disease is also called childhood non-tropical sprue. • A gluten-free diet cures the celiac disease. • The sprue is an infectious process that is cured by antibiotics. • Celiac disease is an autoimmune phenomenon. Epidemiology of Celiac...

2 - 4 days Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.