Cefixime

Usual Adult Dose for: • • • • Usual Pediatric Dose for: • • • • • • Additional dosage information: • • • • • Usual Adult Dose for Urinary Tract Infection 400 mg orally once a day OR 200 mg orally every 12 hours Use: Treatment of patients with uncomplicated urinary tract infections caused by susceptible isolated of Escherichia coli and Proteus mirabilis Usual Adult Dose for Otitis Media Chewable tablets/oral suspension: 400 mg orally once a day OR 200 mg orally every 12 hours Duration of therapy: • Streptococcus pyogenes infections: 10 days Comments: • Chewable tablets or oral suspensions should be used for this indication. • Efficacy for S pyogenes was studied in fewer than 10 patients. • The overall response in the treatment of otitis media caused by Streptococcus pneumoniae was approximately 10% lower than in the comparator drug. Use: Treatment of otitis media caused by susceptible isolates of Haemophilus influenzae, Moraxella catarrhalis, and S pyogenes Usual Adult Dose for Tonsillitis/Pharyngitis Chewable tablets/oral suspension: 400 mg orally once a day OR 200 mg orally every 12 hours • Duration of therapy: 10 days Comments: • Penicillin is usually the drug of choice for the treatment of S pyogenes infections; however, this drug is effective in eradication of S pyogenes from the nasopharynx. • There are no data on the efficacy of this drug in the prevention of rheumatic fever. Use: Treatment of pharyngitis and tonsillitis caused by susceptible isolates of S pyogenes U...

Cefixime Generic name: cefixime [ sef-IX-eem] Brand name: Dosage forms: oral capsule, oral powder for reconstitution, oral tablet, oral chewable tablet Drug class: Medically reviewed by • • • • • • • What is cefixime? Cefixime is an antibiotic that may be used to treat many different types of infections caused by bacteria. Cefixime stops bacteria from forming a cell wall, which bacteria need to survive. This decreases the number of bacteria in your body, which helps your body fight the infection. Cefixime was FDA approved in 1989. Warnings You should not take cefixime if you are allergic to cefixime, or to similar Related/similar drugs Before taking this medicine You should not take this medicine if you are allergic to cefixime or to other cephalosporin antibiotics, such as: • • • • • cefditoren (Spectracef); • • • ceftibuten (Cedax); • cefuroxime (Ceftin); • • To make sure cefixime is safe for you, tell your doctor if you are allergic to any drugs, especially The chewable tablet form of cefixime may contain phenylalanine. Talk to your doctor before using this form if you have It is not known whether cefixime will harm an unborn baby. Tell your doctor if you are pregnant. It is not known whether cefixime passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding. You may need to stop nursing while you are taking cefixime. The cefixime suspension (liquid) contains sucrose. Talk to your doctor before using this form of cefixime if ...

Take this The dosage is based on your medical condition and response to treatment. In children, the dosage is also based on For the best effect, take this antibiotic at evenly spaced times. To help you remember, take this medication at the same time(s) every day. Continue to use this medication until the full prescribed amount is finished, even if symptoms disappear after a few days. Stopping the medication too early may allow bacteria to continue to grow, which may result in a relapse of the infection. Tell your doctor if your condition lasts or gets worse. Remember that this Tell your doctor right away if you have any serious side effects, including: nausea/ This medication may rarely cause a severe intestinal condition due to a bacteria called C. difficile. This condition may occur during treatment or weeks to months after treatment has stopped. Tell your doctor right away if you develop: If you have these symptoms, do not use anti- Use of this medication for prolonged or repeated periods may result in oral A very serious This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist. In the US - Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch. In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345. Before taking Before using this Cefixime...

Description and Brand Names Drug information provided by: US Brand Name • Suprax Descriptions Cefixime is used to treat bacterial infections in many different parts of the body. It belongs to the class of medicines known as cephalosporin antibiotics. It works by killing bacteria or preventing their growth. However, this medicine will not work for colds, flu, or other virus infections.

What is cefixime, and how does it work (mechanism of action)? Cefixime is a semi-synthetic (partially man-made), oral antibiotic in the cephalosporin family of antibiotics. The cephalosporin family includes Cefixime is active against a very wide spectrum of bacteria such as: • • • • Hemophilus influenzae • Moraxella catarrhalis • • Klebsiella • Proteus mirabilis • • • Neisseria gonorrhoeae The FDA approved cefixime in April 1989. What brand names are available for a cefixime? Suprax Is cefixime available as a generic drug? Yes Do I need a prescription for a cefixime? Yes What else should I know about cefixime? What preparations of cefixime are available? Tablets: 400 mg. Tablet (Chewable): 100, 200 mg. Suspension: 100,200, 500 mg/5 ml. How should I keep cefixime stored? Tablets and oral suspension may be stored at room temperature, 20 C to 25 C (68 F to 77 F), in a tightly closed container. Suspension may be refrigerated or stored at room temperature after mixing. Urinary Tract Infection (UTI) A urinary tract infection (UTI) is an infection of the bladder, kidneys, ureters, or urethra. E. coli, a type of bacteria that lives in the bowel and near the anus, causes most UTIs. UTI symptoms include pain, abdominal pain, mild fever, urinary urgency, and frequency. Treatment involves a course of antibiotics. • Laryngitis Laryngitis is an inflammation of the voice box (vocal cords). The most common cause of acute laryngitis is an infection, which inflames the vocal cords. Symptoms...

Dosage Forms & Strengths capsule • 400mg tablet, chewable • 100mg • 200mg oral suspension • 100mg/5mL • 200mg/5mL • 500mg/5mL Acute Exacerbations of Chronic Bronchitis Indicated in the treatment of acute exacerbations of chronic bronchitis caused by susceptible isolates of Streptococcus pneumoniae and Haemophilus influenzae 400 mg/day PO in single daily dose or divided q12hr Otitis Media Indicated in the treatment of otitis media caused by susceptible isolates of Haemophilus influenzae, Moraxella catarrhalis, and Streptococcus pyogenes 400 mg/day PO in single daily dose or divided q12hr Pharyngitis/Tonsillitis Indicated in the treatment of pharyngitis and tonsillitis caused by susceptible isolates of Streptococcus pyogenes 400 mg/day PO in single daily dose or divided q12hr Uncomplicated Gonorrhea Alternative treatment of uncomplicated urogenital, anorectal, or pharyngeal gonorrhea if ceftriaxone unavailable; no longer indicated as first-line treatment, per CDC guidelines 400 mg PO once plus azithromycin 1 g PO once (preferred) or alternatively doxycycline 100 mg PO q12hr for 7 days CDC STD guidelines: MMWR Recomm Rep. June 5, 2015:64(RR3);1-137 Uncomplicated Urinary Tract Infections Indicated in the treatment of uncomplicated urinary tract infections caused by susceptible isolates of Escherichia coli and Proteus mirabilis 400 mg/day PO in single daily dose or divided q12hr Typhoid Fever (Off-label) 15-20 mg/kg/day; not to exceed 100-200 mg BID x 7-14 days (WHO 2OO3) Dosin...

Medical uses Cefixime treats infections of the: • Urinary tract: Uncomplicated urinary tract infections caused by susceptible isolates of Escherichia coli and Proteus mirabilis. • Ear: • Throat: Tonsillitis and pharyngitis caused by • Chest and lungs: Chronic bronchitis caused by • Cervix and urethra: Gonorrhea (cervical/urethral) caused by susceptible isolates of Neisseria gonorrhoeae (penicillinase-and non-penicillinase-producing isolates). • Skin and soft tissue infection: effective against group A and B beta-hemolytic streptococci. However, Staphylococcus aureus, coagulase-negative staphylococci and enterococci are resistant. It is also used to treat Spectrum of bacterial susceptibility Cefixime is a broad spectrum cephalosporin antibiotic and is commonly used to treat bacterial infections of the ear, urinary tract, and upper respiratory tract. The following represents MIC susceptibility data for a few medically significant microorganisms: • Escherichia coli: 0.015 µg/mL – 4 µg/mL • Haemophilus influenzae: ≤0.004 µg/mL – >4 µg/mL • Proteus mirabilis: ≤0.008 µg/mL – 0.06 µg/mL • Streptococcus pneumoniae: 0.12 µg/mL • Staphylococcus aureus: >128 µg/mL (Resistant) • Enterobacter spp. : >128 µg/mL (Resistant) Mechanism of action The bactericidal action of Cefixime is due to the inhibition of cell wall synthesis. It binds to one of the Absorption Only 40–50% is absorbed from the GI tract (oral bioavailability). Absorption may be slowed but not decreased when taken with food...

Dosage Forms & Strengths capsule • 400mg tablet, chewable • 100mg • 200mg oral suspension • 100mg/5mL • 200mg/5mL • 500mg/5mL Acute Exacerbations of Chronic Bronchitis Indicated in the treatment of acute exacerbations of chronic bronchitis caused by susceptible isolates of Streptococcus pneumoniae and Haemophilus influenzae 400 mg/day PO in single daily dose or divided q12hr Otitis Media Indicated in the treatment of otitis media caused by susceptible isolates of Haemophilus influenzae, Moraxella catarrhalis, and Streptococcus pyogenes 400 mg/day PO in single daily dose or divided q12hr Pharyngitis/Tonsillitis Indicated in the treatment of pharyngitis and tonsillitis caused by susceptible isolates of Streptococcus pyogenes 400 mg/day PO in single daily dose or divided q12hr Uncomplicated Gonorrhea Alternative treatment of uncomplicated urogenital, anorectal, or pharyngeal gonorrhea if ceftriaxone unavailable; no longer indicated as first-line treatment, per CDC guidelines 400 mg PO once plus azithromycin 1 g PO once (preferred) or alternatively doxycycline 100 mg PO q12hr for 7 days CDC STD guidelines: MMWR Recomm Rep. June 5, 2015:64(RR3);1-137 Uncomplicated Urinary Tract Infections Indicated in the treatment of uncomplicated urinary tract infections caused by susceptible isolates of Escherichia coli and Proteus mirabilis 400 mg/day PO in single daily dose or divided q12hr Typhoid Fever (Off-label) 15-20 mg/kg/day; not to exceed 100-200 mg BID x 7-14 days (WHO 2OO3) Dosin...

What is cefixime, and how does it work (mechanism of action)? Cefixime is a semi-synthetic (partially man-made), oral antibiotic in the cephalosporin family of antibiotics. The cephalosporin family includes Cefixime is active against a very wide spectrum of bacteria such as: • • • • Hemophilus influenzae • Moraxella catarrhalis • • Klebsiella • Proteus mirabilis • • • Neisseria gonorrhoeae The FDA approved cefixime in April 1989. What brand names are available for a cefixime? Suprax Is cefixime available as a generic drug? Yes Do I need a prescription for a cefixime? Yes What else should I know about cefixime? What preparations of cefixime are available? Tablets: 400 mg. Tablet (Chewable): 100, 200 mg. Suspension: 100,200, 500 mg/5 ml. How should I keep cefixime stored? Tablets and oral suspension may be stored at room temperature, 20 C to 25 C (68 F to 77 F), in a tightly closed container. Suspension may be refrigerated or stored at room temperature after mixing. Urinary Tract Infection (UTI) A urinary tract infection (UTI) is an infection of the bladder, kidneys, ureters, or urethra. E. coli, a type of bacteria that lives in the bowel and near the anus, causes most UTIs. UTI symptoms include pain, abdominal pain, mild fever, urinary urgency, and frequency. Treatment involves a course of antibiotics. • Laryngitis Laryngitis is an inflammation of the voice box (vocal cords). The most common cause of acute laryngitis is an infection, which inflames the vocal cords. Symptoms...

Take this The dosage is based on your medical condition and response to treatment. In children, the dosage is also based on For the best effect, take this antibiotic at evenly spaced times. To help you remember, take this medication at the same time(s) every day. Continue to use this medication until the full prescribed amount is finished, even if symptoms disappear after a few days. Stopping the medication too early may allow bacteria to continue to grow, which may result in a relapse of the infection. Tell your doctor if your condition lasts or gets worse. Remember that this Tell your doctor right away if you have any serious side effects, including: nausea/ This medication may rarely cause a severe intestinal condition due to a bacteria called C. difficile. This condition may occur during treatment or weeks to months after treatment has stopped. Tell your doctor right away if you develop: If you have these symptoms, do not use anti- Use of this medication for prolonged or repeated periods may result in oral A very serious This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist. In the US - Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch. In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345. Before taking Before using this Cefixime...