Cefpodoxime

Cefpodoxime is a cephalosporin (SEF a low spor in) antibiotic that is used to treat infections caused by bacteria. This includes infections of the sinus, throat, ear, skin, bladder, or lungs. Cefpodoxime is also used to treat gonorrhea. Cefpodoxime may also be used for purposes not listed in this medication guide. You should not take this medicine if you are allergic to cefpodoxime or any other cephalosporin antibiotic (cefdinir, cefalexin, Keflex, Omnicef, and others). Tell your doctor if you have ever had: • kidney disease; • urination problems; • a stomach or intestinal disorder such as colitis; or • an allergy to any type of penicillin. Tell your doctor if you are pregnant. You should not breastfeed while using cefpodoxime. Cefpodoxime is not approved for use by anyone younger than 2 months old. Side Effects What are the side effects of Cefpodoxime (Vantin)? Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning in your eyes, skin pain, red or purple skin rash that spreads and causes blistering and peeling). Call your doctor at once if you have: • severe stomach pain, diarrhea that is watery or bloody (even if it occurs months after your last dose); • fever, chills, sore throat, mouth sores, swollen glands, joint pain, or not feeling well; • a seizure; or • liver problems--upper stomach pain, loss of appetite, dark urine, clay-colored stool...

Check with your doctor immediately if any of the following side effects occur: More common • Diarrhea • loose stools Less common • Change in the color, amount, or odor of vaginal discharge Rare • Abdominal or stomach cramps or tenderness • black, tarry stools • bladder pain • bleeding gums • bloating or swelling of the face, arms, hands, lower legs, or feet • bloody nose • bloody or cloudy urine • blurred vision • burning while urinating • chest pain • collection of blood under the skin • confusion • continuing ringing or buzzing or other unexplained noise in the ears • cough or hoarseness • cough producing mucus • dark urine • decreased urination • decreased urine output • deep, dark purple bruise • diarrhea, watery and severe, which may also be bloody • difficult or labored breathing • difficult, burning, or painful urination • difficulty with breathing or troubled breathing • dilated neck veins • dizziness • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position • dry mouth • extreme fatigue • fainting • fast, irregular, pounding, or racing heartbeat or pulse • feeling of warmth or heat • fever or chills • flushing or redness of the skin, especially on the face and neck • frequent urge to urinate • general body swelling • headache • hearing loss • heavier menstrual periods • increase in heart rate • increased thirst • increased urge to urinate during the night • increased weight • irregular breathing • irregular heartbeat • it...

Identification Summary Cefpodoxime is a third-generation cephalosporin antibiotic used in the treatment of various bacterial infections, including gonorrhea, community acquired pneumonia, and sinusitis. Generic Name Cefpodoxime DrugBank Accession Number DB01416 Background Cefpodoxime is an oral third generation cephalosporin antibiotic with effectiveness against most Gram positive and Gram negative bacteria. Commonly used to treat acute otitis media, pharyngitis, and sinusitis, cefpodoxime proxetil is a prodrug which is absorbed and de-esterified by the intestinal mucosa to Cefpodoxime. Type Small Molecule Groups Approved, Vet approved Structure Learn more Pharmacodynamics Cefpodoxime is shown to be effective against most Gram positive and Gram negative bacteria, except Pseudomonas aeruginosa, Enterococcus, and Bacteroides fragilis. Mechanism of action Cefpodoxime is active against a wide spectrum of Gram-positive and Gram-negative bacteria. Cefpodoxime is stable in the presence of beta-lactamase enzymes. As a result, many organisms resistant to penicillins and cephalosporins, due to their production of beta-lactamase, may be susceptible to cefpodoxime. Cefpodoxime is inactivated by certain extended spectrum beta-lactamases. The bactericidal activity of cefpodoxime results from its inhibition of cell wall synthesis. The active metabolite of cefpodoxime binds preferentially to penicillin binding protein 3, which inhibits production of peptidoglycan, the primary constituent ...

Key:WYUSVOMTXWRGEK-HBWVYFAYSA-N Y N Y Cefpodoxime is an oral, third-generation Cefpodoxime inhibits peptidoglycan synthesis in bacterial cell walls. It has an oral bioavailability of approximately 50%, which is increased when taken with food. It has an elimination half-life of 2-3 hours in adults, which is prolonged in renal failure. Approved indications include community acquired pneumonia, uncomplicated skin and skin structure infections, and uncomplicated urinary tract infections. It was patented in 1980 and approved for medical use in 1989. Spectrum of bacterial susceptibility and resistance [ ] Cefpodoxime has been used to treat gonorrhoea, tonsillitis, pneumonia, and bronchitis. The following minimum inhibitory concentrations have been reported: • • Neisseria gonorrhoeae: 0.004 – 0.06 μg/ml • Streptococcus pyogenes: ≤0.004 – 2 μg/ml Brand name [ ] Vantin (by Toraxim (by Delta Pharma Ltd. Bangladesh) Trucef (by Renata Limited, Bangladesh) Tricef (by Alkaloid Skopje, North Macedonia) Orelox (by MAPDOX-CV: Cefpodoxime and Clavulanic acid combination MONOTAX O (Cefpodoxime)/ MONOTAX CV (Cefpodoxime and Clavulanic acid combination) (by Zydus Healthcare Ltd.) ACXIME 200/CV (by Allencia Biosciences, India) POSTPOD-50 (Cefpodoxime 50mg/5ml) (by Laafon Galaxy Pharmaceuticals) References [ ] • Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p.495. 9783527607495. • (PDF). • www.finecurepharma.com . Retrieved 2019-05-26. • . Retrieved 2012-03-27....