Dextromethorphan class

Dosage Forms & Strengths dextromethorphan/bupropion tablet, extended-release • 45mg/105mg Major Depressive Disorders Indicated for major depressive disorder (MDD) 1 tablet PO qDay in AM for 3 days, then increase to 1 tablet BID given at least 8 hr apart Maximum recommended dose: 1 tablet BID; do not exceed 2 doses/24 hr Dosage Modifications Renal impairment • Mild (eGFR ≥60 mL/min/1.73 m 2): No dose adjustment required • Moderate (eGFR 30-59 mL/min/1.73 m 2): 1 tablet PO qAM (do not increase initial dose) • Severe (eGFR 15-29 mL/min/1.73 m 2): Not recommended Hepatic impairment • Mild or moderate (Child-Pugh A or B): No dose adjustment required • Severe (Child-Pugh C): Not recommended (not evaluated) Poor CYP2D6 metabolizers or coadministration with CYP2D6 inhibitors • 1 tablet PO qAM (do not increase initial dose) Switching to or from MOAI antidepressant • At least 14 days must elapse between discontinuing an MAOI and initiating dextromethorphan/bupropion • Conversely, at least 14 days must be allowed after stopping dextromethorphan/bupropion before starting an MAOI antidepressant Dosing Considerations Not for use during pregnancy; use alternate antidepressant for females planning to become pregnant Screen patients for bipolar disorder, mania, or hypomania before initiating Screen for other medications containing bupropion and dextromethorphan Assess blood pressure, and monitor periodically during treatment Contraindicated (11) • eliglustat bupropion increases levels of e...

What is dextromethorphan, and what is it used for? Dextromethorphan is a medication used to control Dextromethorphan is available Dextromethorphan suppresses cough by reducing the sensitivity of cough receptors in the brain region that stimulate the cough reflex and preventing the transmission of cough impulses. Dextromethorphan is a non-opioid drug derived from levorphanol, an opioid analgesic, and is structurally similar to opioid Dextromethorphan does not interact with opioid receptors and hence, does not have analgesic or addictive properties, however, it increases the levels of chemical messengers such as serotonin, and has the potential for abuse. Warnings • Do not take dextromethorphan if you are • Do not use dextromethorphan simultaneously with • Do not administer dextromethorphan OTC to children younger than 4 years; it can cause serious side effects; use with caution in children of 4-11 years • Dextromethorphan may cause • Do not take for persistent or • Some brands of dextromethorphan may contain • Use with caution in patients who are sedated, debilitated or confined to supine position What are the side effects of dextromethorphan? Common side effects of dextromethorphan include: • • • Drowsiness • Sedation • Nervousness • Restlessness • Confusion • • • • This is not a complete list of all side effects or adverse reactions that may occur from the use of this drug. Call your doctor for medical advice about serious side effects or adverse reactions. You may also r...

Take this Drink plenty of fluids while taking this medication. Fluids will help to break up Dosage is based on your age, medical condition, and response to treatment. Do not increase your dose or take this drug more often than directed. If you are using the liquid form of this medication, carefully measure the dose using a special measuring device/spoon. Do not use a household spoon because you may not get the correct dose. For powder packets, empty the entire contents of the packet onto the Improper use of this medication (abuse) may result in serious harm (such as Tell your doctor if your If your doctor has directed you to use this A very serious This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist. In the US - In the US - Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch. In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345. Before taking this drug, tell your doctor or Before using this This drug may make you dizzy or drowsy. Alcohol or Liquid forms of this product may contain sugar and/or alcohol. Caution is advised if you have The liquid forms and powder packets of this medication may contain aspartame. If you have phenylketonuria (PKU) or any other condition that requires you to restrict your intake of aspartame (or Before hav...