Dmd disease

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Muscular dystrophy causes progressive muscle weakness, and each stage presents with different symptoms Muscular dystrophy is a group of diseases that cause progressive muscle There are different types of muscular dystrophy, and they differ from each other in terms of their symptoms and the type of gene involved. Some of these types also progress and lead to the development of Duchenne muscular dystrophy (DMD) has some of the most severe outcomes and is associated with decreased lifespan. According to the appearance and progression of symptoms, this type of muscular dystrophy can be divided into 3 general stages, although some experts describe the stages of DMD in 4-5 stages. It is important to know what care is needed during each stage, and parents will need to work with a team of doctors from different specialties for a treatment plan. Stage 1: Early ambulatory stage Symptoms of DMD usually appear between 2-5 years of age. The child lags in achieving their developmental milestones, which include A child with DMD will have large calves and difficulty getting up from a sitting position, taking more time than other children of the same age. Climbing stairs also becomes a huge task for them. Between 6-9 years of age, the child may walk on their toes or have a wobbly, abnormal gait. They may seem awkward and clumsy and also get tired easily compared to their peers. Stage 2: Late ambulatory stage Signs of the late ambulatory stage appear during the late childhood or adolescence...

Duchenne Muscular Dystrophy (DMD) What is Duchenne muscular dystrophy? Duchenne muscular dystrophy (DMD) is a genetic disorder characterized by progressive muscle degeneration and weakness due to the alterations ofa protein called dystrophin that helps keep muscle cells intact. DMD is one of four conditions known as dystrophinopathies. The other three diseases that belong to this group are Becker Muscular dystrophy (BMD, a mild form of DMD); an intermediate clinical presentation between DMD and BMD; and DMD-associated dilated cardiomyopathy (heart-disease) with little or no clinical skeletal, or voluntary, muscle disease. DMD symptom onset is in early childhood, usually between ages 2 and 3. The disease primarily affects boys, but in rare cases it can affect girls. In Europe and North America, the prevalence of DMD is approximately 6 per 100,000 individuals. 1,2,3,4 What are the symptoms of DMD? Muscle weakness is the principal symptom of DMD. It can begin as early as age 2 or 3, first affecting the proximal muscles (those close to the core of the body) and later affecting the distal limb muscles (those close to the extremities). Usually, the lower external muscles are affected before the upper external muscles. The affected child might have difficulty jumping, running, and walking. Other symptoms include enlargement of the calves, a waddling gait, and lumbar lordosis (an inward curve of the spine). Later on, the heart and respiratory muscles are affected as well. Progress...