Epinephrine

Epinephrine injection Generic name: epinephrine injection [ EP-i-NEF-rin] Brand names: EpiPen JR 2-Pak, EPIsnap, Symjepi Dosage form: Injection vials, Auto-Injector Drug classes: Medically reviewed by • • • • • • • What is epinephrine injection? Epinephrine injection is used to treat severe Epinephrine injection works to reverse wheezing, severe skin itching, hives, and other symptoms of an allergic reaction and also helps with severely low blood pressure. Epinephrine is a is a hormone and neurotransmitter that acts on alpha and beta receptors to cause the muscles in the airways to relax, and it causes the blood vessels to narrow. Epinephrine is from the drug class of medicine called sympathomimetics. Epinephrine auto-injectors may be kept on hand for self-injection by a person with a history of severe allergic reactions. An Auto-Injector is a hand-held device that automatically injects a measured dose of medicine, it is easier to use in an emergency compared to using vials and needles. Epinephrine is also known as adrenaline and adrenalin. Warnings Seek emergency medical attention after any use of epinephrine to treat a severe allergic reaction. After the injection, you will need to receive further treatment and observation. Before taking this medicine Before using epinephrine auto injector or injection, tell your doctor if any past use of epinephrine injection caused an allergic reaction to get worse. Tell your doctor if you have ever had: • • • • • a thyroid disorder; o...

In small doses it has a greater affinity for beta receptors, but in larger doses it produces more selective action on alpha receptors. Its impact on alpha-1 receptors leads to increased vascular smooth muscle contraction, pupillary dilator muscle contraction, and intestinal sphincter muscle contraction. Its impact on beta-1 receptors leads to increased heart rate, myocardial contractility, and renin-release. Stimulation of beta-2 receptors leads to bronchodilation, which may be useful as an adjunct treatment of asthma exacerbations as well as vasodilation, tocolysis, and increased aqueous humor production. How to Administer Epinephrine Epinephrine is administered differently depending on its reason for use. To treat anaphylaxis, it is best to inject epinephrine in the muscle, preferably the thigh, due to rapid absorption. It's important to note that epinephrine's half-life is approximately two to three minutes. When there are symptoms of anaphylaxis, Medical expert consensus believes that there is no absolute contraindication to epinephrine administration in anaphylaxis. It can be administered in doses appropriate for the severity of the reaction, regardless of the initial signs and symptoms of anaphylaxis. An allergist-immunologist can provide comprehensive professional advice on these matters and should be consulted if they are not already involved in the anaphylaxis plan of care. All patients at risk for future anaphylaxis should carry at least one epinephrine syringe a...

A nurse or other trained health professional will give you this medicine in a medical facility to treat hypotension with septic shock. It is given through a needle placed into one of your veins. If you are using this medicine at home, make sure you or any of your family members understand exactly how to give them. Also, tell your doctor if you or your caregiver has severe arthritis of the hands. If you have any questions about this, check with your doctor. This medicine is injected under the skin or into the muscle of your outer thigh only. Do not inject this medicine into a vein, into the muscle of your buttocks, or into your fingers, toes, hands, or feet. To do so, may increase the chance of having serious side effects. This medicine comes with patient information and instructions leaflet. Read and follow these instructions carefully. Read it again each time you refill your prescription in case there is new information. Ask your doctor or pharmacist if you have any questions. This medicine comes in 3 forms:an autoinjector syringe and needle kit, a prefilled syringe, or a vial. This contains the correct dose of medicine your doctor has prescribed. This medicine comes with an autoinjector trainer and a separate trainer instructions for use. Be sure to practice first with your autoinjector trainer before an allergy emergency happens to make sure you are ready to use the real Auvi-Q®, Adrenaclick®, EpiPen®, or EpiPen Jr® autoinjector in an actual emergency. The autoinjector ...

What is epinephrine? Epinephrine, also called Epinephrine is part of your sympathetic nervous system, which is part of your body’s emergency response system to danger — the “fight-or-flight” response. Medically, the flight-or-flight response is known as the acute stress response. Epinephrine is also called a catecholamine, as are norepinephrine and dopamine. They’re given this name because of a certain molecule in its structure. As a hormone, epinephrine is made from norepinephrine inside of your adrenal gland. What does epinephrine do in the body? As a neurotransmitter, epinephrine plays a small role. Only a small amount is produced in your nerves. It plays a role in metabolism, attention, focus, panic and excitement. Abnormal levels are linked to sleep disorders, anxiety, hypertension and lowered immunity. Epinephrine’s major action is in its role as a hormone. Epinephrine is released by your adrenal glands in response to stress. This reaction causes a number of changes in your body and is known as the fight-or-flight response. What’s the fight-or-flight response? The fight-or-flight response refers to your body’s response to a stressful situation, such as needing to escape danger (moving away from a growling dog) or facing a fear (giving a speech for school or work). The term comes from the choice our ancestors faced when confronted with a dangerous situation — to stay and fight or run to safety. During the fight-or-flight response, you (your brain) perceive danger. Nex...

nervous system: Epinephrine and norepinephrine Physiological actions The actions of epinephrine are complex, owing to its stimulatory effects on α- and β-adrenergic receptors (or adrenoceptors, so named for their reaction to the adrenal hormones), which produce various responses, depending on the specific receptor and the tissue in which it occurs. Hence, epinephrine causes constriction in many networks of minute blood vessels but dilates the blood vessels in the mydriasis (dilation of the pupil) and improved visual O-methyltransferase (COMT) or monoamine oxidase (MAO), by reuptake into nerve endings, and by Clinical significance

Epinephrine is used to treat a number of conditions, including 2 adrenoceptors, such as [ citation needed] Heart problems [ ] While epinephrine is often used to treat Epinephrine infusions may also be used for symptomatic Anaphylaxis [ ] Epinephrine is the drug of choice for treating Intramuscular injection can be complicated in that the depth of subcutaneous fat varies and may result in Asthma [ ] Epinephrine is also used as a 2 agonists are unavailable or ineffective. When given by the subcutaneous or intramuscular routes for asthma, an appropriate dose is 0.3 to 0.5mg. Because of the high intrinsic efficacy (receptor binding ability) of epinephrine, high drug concentrations cause adverse side effects when treating asthma. The value of using nebulized epinephrine in acute asthma is unclear. Croup [ ] Racemic epinephrine has historically been used for the [ fact or opinion?] [ citation needed]. L-form is the active component. Bronchiolitis [ ] There is a lack of consensus as to whether inhaled nebulized epinephrine is beneficial in the treatment of Local anesthetics [ ] When epinephrine is mixed with local anesthetics, such as Epinephrine is mixed with Upper airway obstruction [ ] Upper airway obstruction with edema and stridor can be treated with racemic epinephrine. Adverse effects [ ] Adverse reactions to adrenaline include Rarely, exposure to medically administered epinephrine may cause Use is contraindicated in people on nonselective Mechanism of action [ ] See also:...

Adrenalin, Allerject, Anapen, Articadent, Astracaine, Auvi-Q, Citanest, Citanest Forte, Emerade, Epipen, Lignospan, Marcaine, Marcaine With Epinephrine, Octocaine, Octocaine With Epinephrine, Orabloc, Scandonest, Sensorcaine, Sensorcaine With Epinephrine, Septanest, Septocaine, Symjepi, Ultacan, Ultracaine, Vivacaine, Xylocaine, Xylocaine With Epinephrine, Zorcaine Generic Name Epinephrine DrugBank Accession Number DB00668 Background Epinephrine, also known as adrenaline, is a hormone and neurotransmitter and produced by the adrenal glands that can also be used as a drug due to its various important functions. Though it has long been used in the treatment of hypersensitivity reactions, epinephrine in the auto-injector form (EpiPen) has been available since 1987 in the USA. Many new products/biosimilars and dosage routes have been approved under various names over the last several decades In general, the most common uses of parenteral epinephrine are to relieve respiratory distress due to bronchospasm, to provide rapid relief of hypersensitivity (anaphylactic or anaphylactoid) reactions to drugs, animal serums and other allergens, and to prolong the action of infiltration anesthetics Type Small Molecule Groups Approved, Vet approved Structure Close Weight Average: 183.2044 Monoisotopic: 183.089543287 Chemical Formula C 9H 13NO 3 Synonyms • (−)-(R)-epinephrine • (−)-3,4-dihydroxy-α-((methylamino)methyl)benzyl alcohol • (−)-adrenaline • (R)-(-)-Adnephrine • (R)-(-)-Adrenaline...

Description and Brand Names Drug information provided by: US Brand Name • Adrenaclick • Adrenalin • Adrenalin Chloride • Auvi-Q • Epipen • Epipen Jr • Symjepi • Twinject Descriptions Epinephrine injection is used for emergency treatment of severe allergic reactions (including anaphylaxis) to insect bites or stings, medicines, foods, or other substances. It is also used to treat anaphylaxis caused by unknown substances or triggered by exercise. Epinephrine injection is also used to increase blood pressure in adult patients with hypotension (low blood pressure) and septic shock. This medicine is available only with your doctor's prescription. This product is available in the following dosage forms: • Solution • Portions of this document last updated: May 01, 2023 Copyright: © Merative US L.P. 1973, 2023. All rights reserved. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes. • •

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