Function of androgen

The androgen receptor ( AR), also known as NR3C4 (nuclear receptor subfamily 3, group C, member 4), is a type of The main function of the androgen receptor is as a Function [ ] Effect on development [ ] In some cell types, testosterone interacts directly with androgen receptors, whereas, in others, testosterone is converted by Androgens cause slow maturation of the bones, but more of the potent maturation effect comes from the Maintenance of male skeletal integrity [ ] Via the androgen receptor, androgens play a key role in the maintenance of male skeletal integrity. The regulation of this integrity by androgen receptor (AR) signaling can be attributed to both Role in females [ ] The AR plays a role in regulating female sexual, somatic, and behavioral functions. Experimental data using AR Moreover, the importance of understanding female androgen receptors lies in their role in several genetic disorders including androgen insensitivity syndrome (AIS). [ citation needed] Mechanism of action [ ] Genomic [ ] The primary mechanism of action for androgen receptors is One function of androgen receptor that is independent of direct binding to its target DNA sequence is facilitated by recruitment via other Androgen receptor is modified by Non-genomic [ ] More recently, androgen receptors have been shown to have a second mode of action. As has been also found for other Genetics [ ] Gene [ ] In humans, the androgen receptor is encoded by the AR Deficiencies [ ] At least 165 disease-c...

Androgen Insuffiency in Women Circulating androgens are found in much higher concentrations than estrogens, and are involved in a variety of biochemical and physiological functions. Androgen insufficiency syndrome, characterized by low libido, decreased arousal, orgasm, motivation, lack of well being, fatigue, adequate estrogen level, and low androgen levels, is thought to be responsible for up to 30-50% of the cases of sexual dysfunction in women. Numerous studies have described and clarified the effect of androgens in male sexuality. It is only recently, however, that studies have been performed to illustrate the equally important action of androgens on the sexual functioning of women. In women androgens act on a variety of organs ranging from the mammary gland to the uterus, oviducts, and vagina. Not only are androgens essential for reproductive development in women, but they are also vital to the production of estrogens, and for the maintenance of sexual libido. Androgens have a three-fold action on female sexual function. They (1) increase libido by providing the fuel for a woman’s psychosexual stimulation, (2) increase sensitivity and blood flow to the external genitalia, and (3) increase the intensity of sexual gratification. Although androgens have been extensively studied, their role in sexual functioning is poorly understood. Recent investigations have implicated androgens as modulators of sexual desire, arousal, and orgasm in women. Thus, the lack of androgens h...

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