- A single residue in influenza virus H2 hemagglutinin enhances the breadth of the B cell response elicited by H2 vaccination
- Systemic and respiratory T
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A single residue in influenza virus H2 hemagglutinin enhances the breadth of the B cell response elicited by H2 vaccination
• Article • 03 February 2022 A single residue in influenza virus H2 hemagglutinin enhances the breadth of the B cell response elicited by H2 vaccination • ORCID: orcid.org/0000-0002-2583-1949 • • ORCID: orcid.org/0000-0002-3775-6560 • ORCID: orcid.org/0000-0001-5741-3699 • • • • • ORCID: orcid.org/0000-0002-3087-8397 • • • • • ORCID: orcid.org/0000-0002-3935-4637 , • ORCID: orcid.org/0000-0002-2147-186X • • • • ORCID: orcid.org/0000-0001-5767-1532 • • ORCID: orcid.org/0000-0003-3560-232X • … • ORCID: orcid.org/0000-0003-0616-9117 Show authors Nature Medicine volume 28, pages 373–382 ( 2022) Conserved epitopes on the influenza hemagglutinin (HA) stem are an attractive target for universal vaccine strategies as they elicit broadly neutralizing antibodies. Such antibody responses to stem-specific epitopes have been extensively characterized for HA subtypes H1 and H5 in humans. H2N2 influenza virus circulated 50 years ago and represents a pandemic threat due to the lack of widespread immunity, but, unlike H1 and H5, the H2 HA stem contains Phe45 HA2 predicted to sterically clash with HA stem-binding antibodies characterized to date. To understand the effect of Phe45 HA2, we compared the HA stem-specific B cell response in post hoc analyses of two phase 1 clinical trials, one testing vaccination with an H2 ferritin nanoparticle immunogen ( Studies estimating the worldwide influenza-associated mortality between 1999 and 2015 show that yearly influenza virus epidemics are associa...
Systemic and respiratory T
• Article • • 09 October 2020 Systemic and respiratory T-cells induced by seasonal H1N1 influenza protect against pandemic H2N2 in ferrets • ORCID: orcid.org/0000-0001-7549-5683 • • • • … • ORCID: orcid.org/0000-0003-3167-2435 Show authors Communications Biology volume 3, Article number: 564 ( 2020) Traditional influenza vaccines primarily induce a narrow antibody response that offers no protection against heterosubtypic infections. Murine studies have shown that T cells can protect against a broad range of influenza strains. However, ferrets are a more potent model for studying immune correlates of protection in influenza infection. We therefore set out to investigate the role of systemic and respiratory T cells in the protection against heterosubtypic influenza A infections in ferrets. H1N1-priming induced systemic and respiratory T cells that responded against pandemic H2N2 and correlated with reduced viral replication and disease. CD8-positive T cell responses in the upper and lower respiratory tract were exceptionally high. We additionally confirmed that H2N2-responsive T cells are present in healthy human blood donors. These findings underline the importance of the T cell response in influenza immunity and show that T cells are a potent target for future universal influenza vaccines. Influenza A virus (IAV) remains a threat to human health despite the availability of vaccines The impact of influenza strains evading the human immune response is illustrated by the pand...
