Hand foot syndrome

A rare disease is defined as a condition that affects fewer than 1 in 200,000 patients in the United States or 1 in 2000 in Europe. Many rare diseases are genetic (caused by change in DNA), which change can be inherited, spontaneous, or epigenetic. Since there are many genes (~20,000), there are many possible defects. To date, about 7000 Rare Diseases have been identified. Hand-foot-genital syndrome is a rare condition that affects the development of the hands and feet, the urinary tract, and the reproductive system. People with this condition have abnormally short thumbs and first (big) toes, small fifth fingers that curve inward (clinodactyly), short feet, and fusion or delayed hardening of bones in the wrists and ankles. The other bones in the arms and legs are normal. Abnormalities of the genitals and urinary tract can vary among affected individuals. Many people with hand-foot-genital syndrome have defects in the ureters, which are tubes that carry urine from each kidney to the bladder, or in the urethra, which carries urine from the bladder to the outside of the body. Recurrent urinary tract infections and an inability to control the flow of urine (urinary incontinence) have been reported. About half of males with this disorder have the urethra opening on the underside of the penis (hypospadias). People with hand-foot-genital syndrome are usually able to have children (fertile). In some affected females, problems in the early development of the uterus can later incre...

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Overview Hand-foot-and-mouth disease is a mild, contagious viral infection common in young children. Symptoms include sores in the mouth and a rash on the hands and feet. Hand-foot-and-mouth disease is most commonly caused by a coxsackievirus. There's no specific treatment for hand-foot-and-mouth disease. Frequent hand-washing and avoiding close contact with people who have hand-foot-and-mouth disease may help lower your child's risk of infection. Hand-foot-and-mouth disease on the foot Hand-foot-and-mouth disease often causes a rash of painful, blister-like lesions on the soles of the feet. Rashes appear differently depending on skin tone. Hand-foot-and-mouth disease may cause all of the following symptoms or only some of them. They include: • Fever. • Sore throat. • Feeling sick. • Painful, blister-like lesions on the tongue, gums and inside of the cheeks. • A rash on the palms, soles and sometimes the buttocks. The rash is not itchy, but sometimes it has blisters. Depending on skin tone, the rash may appear red, white, gray, or only show as tiny bumps. • Fussiness in infants and toddlers. • Loss of appetite. The usual period from initial infection to the time symptoms appear (incubation period) is 3 to 6 days. Children may get a fever and develop a sore throat. They sometimes lose their appetites and don't feel well. One or two days after the fever begins, painful sores may develop in the front of the mouth or throat. A rash on the hands and feet and sometimes on the bu...