Malignant meaning

Metastasis means that cancer has spread to a different part of your body part than where it started. When this happens, doctors say the cancer has “metastasized.” The terms "metastatic cancer," "advanced cancer," and " How do metastases develop? Metastases is the plural form of metastasis. Metastases most commonly develop when cancer cells break away from the main tumor and enter the body's bloodstream or lymphatic system. These systems carry fluids around the body. This means that the cancer cells can travel far from the original tumor and form new tumors when they settle and grow in a different part of the body. Metastases can also develop when cancer cells from the main tumor break off and grow in nearby areas, such as in the liver, lungs, or bones. Any type of cancer can spread. Whether this happens depends on several factors, including: • The type of cancer • How fast the cancer is growing • Other factors about the behavior of the cancer that your doctor may find Where can cancer spread? Cancer can spread to almost every part of the body. However certain cancers are more likely to spread to particular areas. For example, here are some common types of cancer and where they commonly metastasize: • Breast cancer tends to spread to the bones, liver, lungs, chest wall, and brain • Lung cancer tends to spread to the brain, bones, liver, and adrenal glands • Prostate cancer tends to spread to the bones • Colon and rectal cancers tend to spread to the liver and lungs Less fre...

• acinic cell carcinoma • acral lentiginous melanoma • aggressive • aggressively • aggressiveness • benignant • bilateral acoustic neurofibromatosis • bilateral acoustic schwannoma • brachytherapy • brain tumor • lymphoma • malignantly • meningioma • metastasis • metastatic • precancerous • SCC • tumor • Waldenstrom macroglobulinemia • Wilms' tumor

A carcinoma is a type of cancer that forms solid tumors. Carcinomas can appear in the skin, breasts, internal organs, and glands. They form in epithelial cells, which line the outer surface of the skin and the covering and lining of organs and internal passageways, such as the gastrointestinal tract. Carcinoma types vary not only by the organs they affect but also by their rate of progression. BCC tends to be slow-growing and least likely to spread, while SCC is generally faster-growing than adenocarcinoma. But many molecular, cellular, hormonal, and physiologic factors can alter the rate by which these and other cancers progress and spread. The majority of breast, colorectal, kidney, liver, lung, oral, pancreatic, and prostate cancers are carcinomas. What Causes Carcinoma? Multiple genetic mutations can accumulate in a progenitor cell (a cell, like a stem cell, that can differentiate to create a specialized cell), and certain combinations of mutations can lead to the development of a cancer stem cell, which produces cancer cells and causes cancer. • They are effectively “immortal” and do not die of programmed cell death (apoptosis) like normal cells do. • They can reproduce exponentially because their growth is unchecked. • They have the ability to penetrate surfaces and directly invade nearby structures. • They have the ability to metastasize (spread) from the site of the original tumor to distant sites, typically when cancer cells break off and are distributed through t...

Recent Examples on the Web The British disc jockey and producer took to Instagram on Monday to reveal that he was recently diagnosed with CNS lymphoma, a disease in which malignant cancer cells form in the lymph tissue of the brain and/or spinal cord, according to the National Cancer Institute’s official website. — USA TODAY, 5 June 2023 Since the 1970s, for example, numerous studies have found that workers exposed to vinyl chloride, which is made from fossil fuels and is primarily used to manufacture PVC, developed malignant liver cancers. — Hiroko Tabuchi, New York Times, 17 Apr. 2023 For example, in 2015 Chinese researchers published that the identification of two fragments of an RNA strand (microRNA) in saliva allowed the detection of malignant pancreatic cancer in 7 out of 10 patients with the disease. — Matías A. Loewy, Discover Magazine, 25 Mar. 2023 For example, in 2015 Chinese researchers published that the identification of two fragments of an RNA strand (microRNA) in saliva allowed the detection of malignant pancreatic cancer in seven out of ten patients with the disease. — Smithsonian Magazine, 17 Mar. 2023 Their aim has been to trick cancer-promoting growth molecules to bind with decoys, thereby blocking the signals that fuel uncontrolled growth of malignant cells. — Corinne Purtill, Los Angeles Times, 7 Dec. 2022 Tumors caused by neurofibromatosis are most often benign but can become malignant, or cancerous, according to the Mayo Clinic. — Sean Neumann, Peopl...

malignant cell A cell that has undergone malignant transformation—i.e., is in a state of permanent proliferation and capable of metastasis. Phenotypic changes in malignant cells General changes • Decreased intercellular adhesion; • Electrical repulsion (due to a loss of anchorage dependence); • Decreased intracellular K+ and Ca2+; • Aneuploidy; • Loss of response to control by the usual cytokines and mitogens; • Ectopic hormone production; • Use of aberrant metabolic pathways; • Biochemical convergence—cells lose features of differentiation and organ-specific features (e.g., microvilli); • Desmosomes, intermediate filaments. Cytopathologic changes • Nucleolar margination (a sign of rapid growth); • Cytologic atypia; • Nuclear irregularity; • Hyperchromasia; • High nuclear:cytoplasmic ratio; • Swelling of mitochondria and flooding of the mitochondrial matrix. Other features • Altered growth parameters and cell behaviour; • Cell surface alterations; • Loss of actin myofilaments; • Increased transforming growth factor release; • Increased protease secretion; • Altered gene transcription; • Immortalisation of cells. Another effect of the malignant rewiring of the cell has to do with its ability to quench the relatively high production of reactive oxygen species (ROS) generated within malignant cells. For example, upregulation of the pentose phosphate pathway (PPP) leads to generation of the ROS-quenching antioxidant glutathione. Slides were evaluated as being negative or posit...

• العربية • বাংলা • བོད་ཡིག • Bosanski • Dansk • Deutsch • Español • فارسی • Galego • Bahasa Indonesia • Magyar • Nederlands • नेपाल भाषा • 日本語 • Norsk nynorsk • Polski • Português • Русский • Simple English • Slovenščina • Српски / srpski • Srpskohrvatski / српскохрватски • Sunda • Svenska • తెలుగు • Türkçe • اردو • 中文 Medical condition Malignancy Other names Malignant tumor ( right) spreads uncontrollably and invades the surrounding tissues; benign tumor ( left) remains self-contained from neighbouring tissue Fatigue, lump(s), change in skin, abnormal bleeding, prolonged cough, unexplained Smoking, sun exposure, genetics - history of malignancy, solid organ transplantation (post-transplant malignancy), Treatment Frequency 442.4 per 100,000 per year Deaths ~10 million per year Malignancy (from male'badly',and -gnus'born') is the tendency of a medical condition to become progressively worse; the term is most familiar as a characterization of A malignant tumor contrasts with a non-cancerous benign tumor in that a malignancy is not self-limited in its growth, is capable of invading into adjacent tissues, and may be capable of spreading to distant tissues. A benign in more general medical use characterises a condition or growth that is not cancerous, i.e. does not spread to other parts of the body or invade nearby tissue. Sometimes the term is used to suggest that a condition is not dangerous or serious. Malignancy in cancers is characterized by Tumours can be detected throug...

Overview Malignant hyperthermia is a severe reaction to certain drugs used for anesthesia. This severe reaction typically includes a dangerously high body temperature, rigid muscles or spasms, a rapid heart rate, and other symptoms. Without prompt treatment, the complications caused by malignant hyperthermia can be fatal. In most cases, the gene that puts you at risk of malignant hyperthermia is inherited, though sometimes it's the result of a random genetic change. Genetic testing can reveal whether you have an affected gene. This genetic disorder is called malignant hyperthermia susceptibility (MHS). Treatments for malignant hyperthermia include the medication dantrolene (Dantrium, Revonto, Ryanodex), ice packs and other measures to cool body temperature, as well as supportive care. Symptoms In most cases, no signs or symptoms of susceptibility to malignant hyperthermia exist until you're exposed to certain drugs used for anesthesia. Signs and symptoms of malignant hyperthermia may vary and can occur during anesthesia or during recovery shortly after surgery. They can include: • Severe muscle rigidity or spasms • Rapid, shallow breathing and problems with low oxygen and high carbon dioxide • Rapid heart rate • Irregular heart rhythm • Dangerously high body temperature • Excessive sweating • Patchy, irregular skin color (mottled skin) In rare cases, people at risk of malignant hyperthermia have shown signs of a reaction after intense physical activity during excessive hea...