Mefenamic acid synthesis

Mefenamic Acid Ponstan (mefenamic acid) has been used to treat mood swings, fatigue, headache, and the general aches and pains that accompany PMS.281 The use of these NSAIDs should be restricted to a 7-day interval, making them unsuitable for the many women who experience PMS for more than 7 days before their period.282 NSAIDs do not reverse the prostaglandin imbalance that causes excessive menstruation, pain, or PMS and has to be used indefinitely unless the cause/s of the imbalance are identified and rectified. From: Botanical Medicine for Women's Health, 2010 Related terms: • Non-Steroidal Anti-Inflammatory Drug • Anticoagulant Agent • Naproxen • Diclofenac • Indometacin • Acetylsalicylic Acid • Warfarin • Ibuprofen • Paracetamol Monica Valentovic, in xPharm: The Comprehensive Pharmacology Reference, 2007 Introduction Mefanamic acid is a nonsteroidal, anti-inflammatory agent. It is a non-selective COX-1 and COX-2 inhibitor Cryer and Feldman (1998), Gierse et al (1999) . Structurally, mefenamic acid is an N-substituted phenylantharanilic acid (fenamate) analogue and structurally is related to meclofenamate. Mefenamic acid exhibits in humans, analgesic and antipyretic effects, but with relatively limited antiinflammatory activity. However, the drug has pronounced gastrointestinal side effects Simon and Mills (1980), Evens (1979), which limit its use. Mefanamic acid appears to offer little benefit over other NSAIDs and its main use is in the treatment of dysmenorrhoea Simo...

Some new aminobenzothiazole derivatives of mefenamic acid were synthesized with potential analgesic and anti-inflammatory properties. The structures of newly synthesized compounds were confirmed by IR, 1H NMR, 13C NMR, mass spectroscopy, and elemental analysis techniques. Analgesic and anti-inflammatory activity of the new compounds were screened by abdominal constriction (writhing) test and carrageenan-induced rat paw edema test, respectively. The synthesized compounds induced considerable decrease in the writhing response in comparison to control and were significantly more potent than mefenamic acid in this test. The anti-inflammatory efficacy of these compounds was screened and showed significant activity when compared to control but the effect was less than that of mefenamic acid. The relative antinociceptive activity of newly synthesized compounds was higher compared to mefenamic acid but they were not considerable anti-inflammatory agents. • D. Tiryaki, M. Sukuroglu, D. S. Dogruer, et al., Med. Chem. Res., 22, 2553 – 2560 (2013). • M. B. Palkar, D. M. Praveen, P. M. Ronad, et al., Med. Chem. Res., 24, 1988 – 2004 (2015). • C. J. Smith, Y. Zhang, and C. M. Koboldt, Proc. Natl. Acad. Sci. USA, 95, 13313 – 13318 (1998). • T. D. Warner, F. Giuliano, and I. Vaynovie, Proc. Natl. Acad. Sci. USA, 96, 563 – 568 (1999). • A. Almasirad, M. Tajik, and D. Bakhtiari, J. Pharm. Pharm. Sci., 8(3), 419 – 425 (2005). • L. M. Jackson and C. J. Hawkey, Exp. Opin. Invest. Drugs, 8, 963...

A novel complex [Cd(mef) 2(CH 3OH)] n, 1, has been synthesized by the interaction of Cd(II) with the non-steroidal antiinflammatory drug mefenamic acid, mef, which has been structurally characterized by spectral (IR, UV–Vis) and X-ray crystallography. This complex is a 1D polymer, consisting of hepta-coordinated Cd atoms connected by six oxygen atoms from four different mef ligands and one oxygen atom from a methanol molecule. The coordination geometry around each metal ion is distorted by the bulky mef ligand. Binding of the synthesized complex with calf thymus DNA (CT-DNA) was investigated by spectroscopic methods (UV–Vis, fluorescence, CD spectroscopy) and viscosity measurements. The complex partially intercalated to DNA with high affinity. The antioxidant activities of ligand mef and complex 1 show this complex has better 1 are higher against both bacteria and fungi than free Cd 2+ or mef. The cytotoxic effect of compound 1 on the human breast cancer cell line (MCF-7) and the bladder cancer cell line (T24) was also much higher than free Cd 2+ or mef. Introduction Metal complexes containing non-steroidal antiinflammatory drugs (NSAID) are among those compounds which have received much attention and increasing interest from a medicinal inorganic chemistry viewpoint [1], [2], [3], [4] and in coordination compounds where the active drugs are ligands [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16]. The action of the NSAID is mainly through inhibition of th...