Monkeypox laboratory diagnosis

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PDF • FIND is tracking the • FIND will be presenting an overview of available diagnostics and those in the pipeline, as well as discussing laboratory research needs, at the upcoming WHO R&D Blueprint meeting Monkeypox research: What are the knowledge gaps and priority research questions? on 2 June 2022, 13:00–19:30 CEST • Data so far indicate that most cases are not life-threatening, and the disease is not easily passed from person to person. In contrast to SARS-CoV-2, monkeypox is a DNA virus; these are usually more stable with regard to mutations and evolution of new variants • Diagnostic capacity for testing and surveillance that was ramped up for COVID-19 will be helpful, but the current situation underscores the need for global surveillance for emerging pathogens and the challenges of boosting capacity to contain outbreaks when and where needed GENEVA, SWITZERLAND – updated 25 May 2022 (originally published 24 May 2022). Diagnostic testing and disease surveillance are back in the spotlight as scientists and public health workers closely monitor the current outbreak of monkeypox that has emerged in cities across Europe, the US, Australia and Canada. While the disease is not easily contracted, and in most cases is not life-threatening, the epidemiology of this outbreak is different to that which has been seen previously. Lack of routine vaccination for smallpox after eradication of that disease in 1980 may have contributed to an increase in monkeypox cases in humans in ...

A definitive diagnosis can only be considered if the appropriate clinical case definition has been met, and the diagnosis has been confirmed by laboratory testing. A high index of suspicion is recommended when evaluating people with a characteristic rash, particularly if the patient meets one of the epidemiologic criteria. As the clinical presentation may be atypical, include mpox in the differential diagnosis when a patient presents with a sexually transmitted infection (STI)-associated or STI-like rash, even if the rash is localized and not (yet) diffuse. Centers for Disease Control and Prevention. Mpox: clinician FAQs. Feb 2023 [internet publication]. https://www.cdc.gov/poxvirus/monkeypox/clinicians/faq.html Mpox is a notifiable condition and one case is considered an outbreak. Immediately report suspected cases to national or local public health authorities, regardless of whether you are also exploring other potential diagnoses. Screening and triage Perform screening and triage at the first point of contact with the health system for all people who present with a rash and fever or lymphadenopathy in order to identify people that have suspected or confirmed infection. World Health Organization. Clinical management and infection prevention and control for monkeypox: interim rapid response guidance, 10 June 2022. June 2022 [internet publication]. https://www.who.int/publications/i/item/WHO-MPX-Clinical-and-IPC-2022.1 • A simplified questionnaire and screening protocol ba...