Norfloxacin

norfloxacin Generic name: norfloxacin (oral) [ nor-FLOX-a-sin] Brand name: Drug class: • • • • • • What is norfloxacin? Norfloxacin is an antibiotic in a group of drugs called fluoroquinolones (flor-o-KWIN-o-lones). Norfloxacin fights bacteria in the body. Norfloxacin is used to treat different bacterial infections of the prostate or urinary tract (bladder and kidneys). Norfloxacin is also used to treat gonorrhea. Norfloxacin may also be used for purposes not listed in this medication guide. What is the most important information I should know about norfloxacin? You should not use this medication if you have ever had swelling or tearing of a tendon caused by taking norfloxacin or similar antibiotics. You may not be able to use norfloxacin if you have a muscle disorder. Tell your doctor if you have a history of myasthenia gravis. Norfloxacin may cause swelling or tearing of a tendon (the fiber that connects bones to muscles in the body), especially in the Achilles' tendon of the heel. This effect may be more likely to occur if you are over 60, if you take steroid medication, or if you have had a kidney, heart, or lung transplant. Stop taking norfloxacin and call your doctor at once if you have sudden pain, swelling, bruising, tenderness, stiffness, or movement problems in any of your joints. Rest the joint until you receive medical care or instructions. What should I discuss with my healthcare provider before taking norfloxacin? You should not use this medication if you are...

Identification Summary Norfloxacin is a broad-spectrum fluoroquinolone antibiotic with variable activity against gram-positive and gram-negative bacteria. Typically reserved for the treatment of UTIs due to accumulation in the urine. Generic Name Norfloxacin DrugBank Accession Number DB01059 Background A synthetic fluoroquinolone (fluoroquinolones) with broad-spectrum antibacterial activity against most gram-negative and gram-positive bacteria. Norfloxacin inhibits bacterial DNA gyrase. Type Small Molecule Groups Approved Structure Learn more Pharmacodynamics Norfloxacin is a quinolone/fluoroquinolone antibiotic. Norfloxacin is bactericidal and its mode of action depends on blocking of bacterial DNA replication by binding itself to an enzyme called DNA gyrase, which allows the untwisting required to replicate one DNA double helix into two. Notably the drug has 100 times higher affinity for bacterial DNA gyrase than for mammalian. Mechanism of action The bactericidal action of Norfloxacin results from inhibition of the enzymes topoisomerase II (DNA gyrase) and topoisomerase IV, which are required for bacterial DNA replication, transcription, repair, and recombination. Norfloxacin is a broad-spectrum antibiotic agent that is shown to be effective against various Gram-positive and Gram-negative bacterial species. The fluorine atom at the 6 position increases potency against gram-negative organisms, and the piperazine moiety at the 7 position is responsible for anti-pseudomona...

What is norfloxacin, and what is it used for? Norfloxacin is a fluoroquinolone antibiotic. Other fluoroquinolones include Norfloxacin works by blocking DNA gyrase enzyme, which is responsible for production and repair of bacterial DNA. Blocking of DNA gyrase leads to bacteria death and prevents worsening of infection. Norfloxacin treats infections caused by gram-positive and gram-negative bacteria like Enterococcus faecalis, Serratia marcescens. The FDA approved the brand name norfloxacin (Noroxin) in October 1986. What are the side effects of norfloxacin? Side effects of norfloxacin are • • • • • • • abnormal heartbeats, and • Norfloxacin as well as other antibiotics in the fluoroquinolone class of antibiotics, has been associated with tendinitis and even rupture of tendons, particularly the Achilles tendon. Many antibiotics, including norfloxacin, can alter the normal bacteria in the colon and encourage the overgrowth of a bacterium responsible for the development of inflammation of the colon, ( C. difficile caused pseudomembranous Fluoroquinolones have neuromuscular blocking activity and can worsen muscles SLIDESHOW Bacterial Infections 101: Types, Symptoms, and Treatments See Slideshow What is the dosage for norfloxacin? • Uncomplicated urinary tract infectionTake 1 tablet (400 mg) by mouth every 12 hours for 3 days • Complicated • For infections caused by • ProstatitisTake 1 tablet (400 mg) by mouth every 12 hours for 28 to 42 days. • Safe and effective use of norflox...

This medicine comes with a Medication Guide. Read and follow the instructions carefully. Ask your doctor if you have any questions. Swallow the tablet with a glass (8 ounces) of water. Drink plenty of fluids while you are being treated with this medicine. Drinking extra water will help to prevent some unwanted effects of norfloxacin. Norfloxacin should be taken at least 1 hour before or 2 hours after a meal, milk, or other dairy products. If you are taking aluminum or magnesium-containing antacids, iron supplements, multivitamins, Didanosine (Videx®), sucralfate (Carafate®), or zinc, do not take them at the same time that you take this medicine. It is best to take these medicines at least 2 hours before or 2 hours after taking norfloxacin. These medicines may keep norfloxacin from working properly. Avoid caffeine-containing products (eg, coffee, soda, or chocolate) while you are using this medicine. Norfloxacin may cause caffeine to stay in your body longer than usual. Keep using this medicine for the full treatment time, even if you feel better after the first few doses. Your infection may not clear up if you stop using the medicine too soon. Dosing The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so. The amount of medicine that you take depe...

Norfloxacin is given to treat urine infections. It is important to complete the full course of treatment. This is to prevent the infection from coming back. The most common side-effects are feeling sick (nausea), diarrhoea, feeling dizzy and headache. Norfloxacin may impair your alertness, so make sure your reactions are normal before you drive and before you use tools or machines. Before taking norfloxacin Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start taking norfloxacin it is important that your doctor knows: • If you are pregnant, trying for a baby, or breastfeeding. • If you are under 18 years of age. • If you have ever experienced a problem with your tendons after taking another quinolone antibiotic (these are called ofloxacin, levofloxacin, ciprofloxacin, moxifloxacin, and nalidixic acid). • If you have any problems with the way your kidneys work. • If you have epilepsy or any other condition that causes fits. • If you have a heart condition, or if you have been told you have an unusual heartbeat. • If you have a condition causing tired and weak muscles, called myasthenia gravis. • If you know you have glucose 6-phosphate dehydrogenase (G6PD) deficiency. This is a genetic disorder which causes problems after eating foods such as fava beans. • If you are taking any other medicines. This includes any medicines you are taking which are available to ...

Norfloxacin belongs to the class of medicines known as quinolone antibiotics. It works by killing bacteria or preventing their growth. However, this medicine will not work for colds, flu, or other virus infections. This medicine is available only with your doctor's prescription. • Portions of this document last updated: June 01, 2023 Copyright: © Merative US L.P. 1973, 2023. All rights reserved. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes. • •

Warning • This medicine may cause severe side effects like irritated or torn tendons; nerve problems in the arms, hands, legs, or feet; and nervous system problems. These can happen alone or at the same time. They can happen within hours to weeks after starting norfloxacin. Some of these effects may not go away, and may lead to disability or death. • The chance of irritated or torn tendons is greater in people over the age of 60; heart, kidney, or lung transplant patients; or people taking steroid drugs. Tendon problems can happen as long as several months after treatment. Call your doctor right away if you have pain, bruising, or swelling in the back of the ankle, shoulder, hand, or other joints. Call your doctor right away if you are not able to move or bear weight on a joint or if you hear or feel a snap or pop. • Call your doctor right away if you have signs of nerve problems. These may include not being able to handle heat or cold; change in sense of touch; or burning, numbness, tingling, pain, or weakness in the arms, hands, legs, or feet. • Call your doctor right away if you have signs of nervous system problems. These may include anxiety, bad dreams, trouble sleeping, change in eyesight, dizziness, feeling confused, feeling nervous or agitated, feeling restless, hallucinations (seeing or hearing things that are not there), new or worse behavior or mood changes like depression or thoughts of suicide, seizures, or very bad headaches. • Do not take if you have myasthe...

Key:OGJPXUAPXNRGGI-UHFFFAOYSA-N Y Norfloxacin, sold under the brand name Noroxin among others, is an Norfloxacin is associated with a number of rare serious adverse reactions as well as spontaneous It was patented in 1977 and approved for medical use in 1983. Medical uses [ ] The initial approval by the • Uncomplicated urinary tract infections (including cystitis) • Complicated urinary tract infections (restricted use) • Uncomplicated urethral and cervical gonorrhea ( however this indication is no longer considered to be effective by some experts due to bacterial resistance) • Prostatitis due to Escherichia coli. • Syphilis treatment: Norfloxacin has not been shown to be effective in the treatment of syphilis. Antimicrobial agents used in high doses for short periods of time to treat gonorrhea may mask or delay the symptoms of incubating syphilis. Although fluoroquinolones are sometimes used to treat In ophthalmology, Norfloxacin licensed use is limited to the treatment of conjunctival infections caused by susceptible bacteria. Norfloxacin has been restricted in the The Norfloxacin is used for prevention of Note: Norfloxacin may be licensed for other uses, or restricted, by the various regulatory agencies worldwide. Contraindications [ ] As noted above, under licensed use, norfloxacin is also now considered to be contraindicated for the treatment of certain sexually transmitted diseases by some experts due to bacterial resistance. Norfloxacin is contraindicated in those wi...