Ofloxacin,

Read the Patient Information Leaflet if available from your For accuracy and to avoid contamination, have another person give the drops if possible. Hold the container in your hand for a few minutes to warm it. This will minimize To apply ear drops, Lie on your side or tilt the affected ear upward. Place the dropper directly over your ear and administer the prescribed number of drops. If you are using the single-use containers, empty the contents of the prescribed number of containers into your ear. For outer Keep your head tilted for about 5 minutes, or insert a soft cotton plug if so directed. Repeat the above steps for your other ear if so directed. Do not rinse the dropper. Replace the dropper cap on the bottle after each use. If you are using the single-dose containers, discard any unused solution after each application. Do not reuse. Use this Inform your doctor if your condition does not improve in 1 week. Report any ear discharge that occurs after the treatment period is completed. Do not use in the Mild irritation/discomfort in the ear, Remember that this Tell your doctor right away if you have any serious side effects, including: tingling/numbness, hearing changes. Use of this medication for prolonged or repeated periods may result in a new fungal A very serious This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist. In the US - Call your doctor for medical advice about side effects. Yo...

Dosage Forms & Strengths tablet • 200mg • 300mg • 400mg Bronchitis Exacerbation 400 mg PO q12hr for 10 days Limitations-of-use: Reserve antimicrobials#fluoroquinolones for patients who do not have other available treatment options for acute bacterial exacerbation of chronic bronchitis Community Acquired Pneumonia 400 mg PO q12hr for 10 days Skin & Skin Structure Infections 400 mg PO q12hr for 10 days Acute, Uncomplicated Urethral and Cervical Gonorrhea No longer recommended for gonorrhea owing to widespread resistance in the US 400 mg PO single dose Nongonococcal Cervicitis/Urethritis or Mixed Infection of Cervix/Urethra 300 mg PO q12hr for 7 days Acute Pelvic Inflammatory Disease 400 mg PO q12hr for 10-14 days Uncomplicated Cystitis Due to E. coli or K. pneumoniae: 200 mg PO q12hr for 3 days Due to other approved pathogens: 200 mg PO q12hr for 7 days Limitations-of-use: Reserve antimicrobials#fluoroquinolones for patients who do not have other available treatment options for uncomplicated urinary tract infections Complicated UTIs 200 mg PO q12hr for 10 days Prostatitis Due to E. Coli 300 mg PO q12hr for 6 weeks Traveler's Diarrhea (Off-label) 300 mg PO q12hr for 1-3 days Dosage Modifications Renal impairment • CrCl 20-50 mL/min: Give q24hr • CrCl <20 mL/min: Give one-half usual dose q24hr Other Indications and Uses Mild to moderate infection due to susceptible strains of designated microorganisms Chlamydia trachomatis, Citrobacter spp, Enterobacter spp, E. coli, Klebsiell...

Boxed Warning Tendonitis and tendon rupture: Fluoroquinolones, including ofloxacin, are associated with an increased risk of tendinitis and tendon rupture in all ages. This risk is further increased in older patients (usually older than 60 years), patients taking corticosteroid drugs, and patients with kidney, heart, or lung transplants. Myasthenia gravis: Fluoroquinolones, including ofloxacin, may exacerbate muscle weakness in persons with myasthenia gravis. Avoid ofloxacin in patients with a known history of myasthenia gravis. Dosage Forms Excipient information presented when available (limited, particularly for generics); consult specific product labeling. Tablet, Oral: Generic: 300 mg, 400 mg Pharmacology Mechanism of Action Ofloxacin is a DNA gyrase inhibitor. DNA gyrase is an essential bacterial enzyme that maintains the superhelical structure of DNA. DNA gyrase is required for DNA replication and transcription, DNA repair, recombination, and transposition; bactericidal Pharmacokinetics/Pharmacodynamics Absorption Well absorbed Distribution Widely distributed into body tissues and fluids, including blister fluid, cervix, lung, ovary, prostatic tissue, skin, and sputum; V d: 2.4 to 3.5 L/kg Excretion Urine: 65% to 80% (as unchanged drug); feces: 4% to 8%; <10% is metabolized Time to Peak Serum: 1 to 2 hours Half-Life Elimination ~9 hours (biphasic: 4 to 5 hours [6.4 to 7.4 hours in elderly patients] and 20 to 25 hours [accounts for <5%]); prolonged with renal impairme...

Check with your doctor immediately if any of the following side effects occur: Rare • Puffiness or swelling of eyes • signs of an allergic reaction, such as hives, itching, rash, swelling of face or lips, tightness in chest, troubled breathing, or wheezing Check with your doctor as soon as possible if any of the following side effects occur: Rare • Dizziness Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: More common • Burning of eye Less common • Blurred vision • eye pain • feeling of something in the eye • increased sensitivity of eye to light • redness, irritation, or itching of eye, eyelid, or inner lining of eyelid • stinging, tearing, or dryness of eye Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088. • Portions of this document last updated: June 01, 2023 Copyright: © Merative US L.P. 1973, 2023. All rights reserved. Information is for End User's use only and may not be sold, redistributed or otherwi...

Proper Use Drug information provided by: To use: • First, wash your hands. Tilt the head back and with the index finger of one hand, press gently on the skin just beneath the lower eyelid and pull the lower eyelid away from the eye to make a space. Drop the medicine into this space. Let go of the eyelid and gently close the eyes. Do not blink. Keep the eyes closed for 1 to 2 minutes, to allow the medicine to come into contact with the infection. • If you think you did not get the drop of medicine into your eyes properly, use another drop. • To keep the medicine as germ-free as possible, do not touch the applicator tip to any surface (including the eye). Also, keep the container tightly closed. To help clear up your eye infection completely, keep using ophthalmic ofloxacin for the full time of treatment, even if your symptoms have disappeared. Do not miss any doses . Dosing The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so. The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine. • For ophthalmic (eye drops) dosage form: • For conjunct...