Pemberton sign

• Home • Featured Resources • Mechanism of Action of Endocrine Drugs • History of hormones • Landmark Diabetes and Endocrinology Trials • Calculators in Endocrinology and Diabetes Care • Endocrinology Practice Guidelines • Endocrine System Mnemonics • Endocrine Journal Club • Dynamic Tests in Endocrinology • Our Books • Endocrine Question Bank • Endocrine Board Review (Guideline Quizzes) • Histology of Endocrine Glands • Endocrinology Fellowship Resources • Internal Medicine Notes • • Learn About Us • Welcome to MyEndoConsult • How To Search • How to Cite Us • The MyEndoConsult Education Team • FAQ Section • Contribute An Article • Short Stories in Endocrinology • Medical Art • Board Review • My Dashboard • Register • Login • Forgot Your Password • Access Locked (Contact Admin) • Upload Your Article An Overview of Pemberton's Sign Pemberton's Sign is a clinical marker used in the detection of thoracic outlet syndrome, specifically in cases of superior vena cava obstruction. First observed and described by the renowned physician Hugh Pemberton in 1946, this sign has since become a diagnostic cornerstone in identifying venous compression in the superior thoracic aperture. A description of the classic Pemberton’s sign noted in patients with large goiters. What are the clinical features? This sign is eponymously named after Dr. Hugh Pemberton, who described this classic physical finding in a letter published in Lancet in 1946 titled “sign of a submerged goitre.” He explained t...

GrepMed and the images sourced through this website are NOT a substitute for clinical judgement. This website was made to assist in clinical knowledge recall and to supplement and support clinician judgement. Although these images are curated, as they are sourced from the community, there is no way to guarantee a consistent standard of accuracy and quality across the library of images. No significant clinical decisions should be made based on these images from this website without first consulting with a board-certified attending physician.

• SVC syndrome • SVC obstruction • Obstruction of the superior vena caval • Obstruction of superior vena caval • Superior vena caval compression • SVC compression • Superior vena cava syndrome • Superior vena cava syndrome (SVCS) • Superior vena cava stenosis • SVC stenosis • Superior vena cava compression • Pemberton maneuver Article: • • • • • Images: • • Clinical presentation Clinical presentation depends on the speed, severity, and location of superior vena cava obstruction 5. Collateral drainage may develop with slow obstruction and patients may have no or only mild symptoms. With acute superior vena cava obstruction, symptoms include facial and neck swelling, facial flushing, bilateral upper extremity swelling, neurological signs, dyspnea, headache, and cough. The Pemberton maneuver 8 might be a useful physical examination tool. The maneuver is achieved by having the patient elevate both arms until they touch the sides of the face. A positive Pemberton sign is marked by the presence of facial congestion and cyanosis, as well as respiratory distress after approximately one minute. Pathology Etiology • malignancy (~90% of cases), most commonly 5: • • • • • • • • radiation-induced stricture Pathophysiology In long-standing cases with 60% or more stenosis, collateral channels are formed to restore venous return. Various collaterals are formed depending on the site of the obstruction: • preazygos: in these conditions mainly the right superior intercostal veins serve as th...

Medical condition Pemberton's sign superior vena cava syndrome Pemberton's sign was named after The Pemberton maneuver is a physical examination tool used to demonstrate the presence of latent pressure in the thoracic inlet. Causes [ ] A positive Pemberton's sign is indicative of et al. reported enlarged cervical lymph nodes associated with hemophagocytic lymphohistiocytosis as the cause of internal jugular vein compression, which presented clinically similar to SVC syndrome. References [ ] • Pemberton, HS (1946). "Sign of submerged goitre". Lancet. 248 (6423): 509. • Wallace, C; Siminoski K (1996). "The Pemberton sign". Ann Intern Med. 125 (7): 568–569. • Pemberton, HS (1946). "Sign of submerged goitre". Lancet. 248 (6423): 509. • Basaria, S; Salvatori R (2004). "Pemberton's sign". New England Journal of Medicine. 350 (13): 1338. • Chow, J; McKim DA; Shennib, H; etal. (1997). "Superior vena cava obstruction secondary to mediastinal lymphadenopathy in a patient with cystic fibrosis". Chest. 112 (5): 1438–1441. • Tekinbas, C; Erol MM; Ozsu S; etal. (2008). "Giant mass due to Castleman's disease causing superior vena cava syndrome". Thorac Cardiovasc Surg. 56 (5): 303–305. • Park, M; Choi JW; Park HJ; etal. (2012). "Hemophagocytic lymphohistiocytosis can mimic the superior vena cava syndrome". J Pediatr Hematol Oncol. 34 (4): 152–154. Further reading [ ] • Abu-Shama Y and Cuny T. Pemberton’s Sign in a Patient with a Goiter. N Engl J Med. 2018;378:e31. DOI: