Pernicious anemia in hindi

Information provided about pernicious: Pernicious meaning in Hindi : Get meaning and translation of Pernicious in Hindi language with grammar,antonyms,synonyms and sentence usages by ShabdKhoj. Know answer of question : what is meaning of Pernicious in Hindi? Pernicious ka matalab hindi me kya hai (Pernicious का हिंदी में मतलब ). Pernicious meaning in Hindi (हिन्दी मे मीनिंग ) is हानिकर.English definition of Pernicious : exceedingly harmful Tags: Hindi meaning of pernicious, pernicious meaning in hindi, pernicious ka matalab hindi me, pernicious translation and definition in Hindi language by ShabdKhoj (From HinKhoj Group).pernicious का मतलब (मीनिंग) हिंदी में जाने |

Pernicious anemia is a rare condition characterized by vitamin B12 deficiency anemia due to lack of intrinsic factor, often caused by autoimmune gastritis. Patients with pernicious anemia have a higher incidence of other autoimmune disorders, such as type 1 diabetes, vitiligo, and autoimmune thyroid issues. Therefore, the disease has a clear autoimmune basis, although the genetic susceptibility factors have thus far remained poorly studied. We conduct a genome-wide association study meta-analysis in 2166 cases and 659,516 European controls from population-based biobanks and identify genome-wide significant signals in or near the PTPN22 (rs6679677, p = 1.91 × 10 −24, OR = 1.63 ), PNPT1 (rs12616502, p = 3.14 × 10 −8, OR = 1.70), HLA-DQB1 (rs28414666, p = 1.40 × 10 −16, OR = 1.38), IL2RA (rs2476491, p = 1.90 × 10 −8, OR = 1.22) and AIRE (rs74203920, p = 2.33 × 10 −9, OR = 1.83) genes, thus providing robust associations between pernicious anemia and genetic risk factors. B12 deficiency anemia due to intrinsic factor deficiency, also known as pernicious anemia, is characterized by impaired B12 uptake caused by lack of intrinsic factor, a glycoprotein produced by epithelial cells of the stomach lining. Intrinsic factor normally binds B12 and facilitates absorption in the intestinal tract. Pernicious anemia is often caused by autoimmune damage to the stomach lining (autoimmune gastritis) in which case the gastric epithelial lining is damaged or destroyed Pernicious anemia is a co...