Charcot-Leyden crystals (CLCs), having both hexagonal and bipyramidal forms, were first reported in 1853 by Jean-Martin Charcot who found tiny crystals in the cardiac blood and spleen of a patient who died from leukemia [ 1 ]. In 1872, Ernst Viktor von Leyden also described colorless crystals found in the sputum of asthma patients [ 2 ].