Facial plethora is a main symptom of Cushing syndrome, a rare condition that’s caused by high levels of cortisol, known as the stress hormone. The hormone cortisol is produced by your adrenal.

In hypothyroidism, the body doesn’t produce enough of the thyroid hormone. This can also cause a puffy face. Other symptoms include fatigue, weight gain, muscle weakness, joint stiffness, and.

12 signs and symptoms of hypothyroidism Fatigue Weight gain Sore muscles and joints Mood and memory changes Feeling cold Constipation High cholesterol Slow heart rate Hair loss Dry skin and weak.