Sodium bicarbonate injection

First and foremost, Exela ® is a pharmaceutical manufacturer of FDA approved prescription products. From its beginning as an R&D organization and contract manufacturer, Exela ® has always focused on developing and manufacturing high quality prescription drugs. Our expertise is in sterile injectable products. Exela ® has developed many first to market generics, and continues to maintain a portfolio of products manufactured in the US market. Exela ® currently provides contract manufacturing and development services for top tier generic companies, although our primary focus is on development of products to be marketed under the Exela ® label. NDC: 51754-0500-1 Strength: 60mg/3ml (20mg/ml) How supplied: 3ml Single Dose glass vial Shelf Pack: 1 vial per carton Orange Book Rating: AP Description: Clear, colorless solution Latex Free: Yes Bar Coded: Yes Caffeine Citrate Injection, USP is a clear, colorless, sterile, non-pyrogenic, preservative-free, aqueous solution. Read more NDC: 51754-0501-3 Strength: 60mg/3ml (20mg/ml) How supplied: 3ml Single Dose glass vial Shelf Pack: 10 vials per carton Orange Book Rating: AP Description: Clear, colorless solution Latex Free: Yes Bar Coded: Yes Caffeine Citrate Injection, USP is a clear, colorless, sterile, non-pyrogenic, preservative-free, aqueous solution. Read more NDC: 51754-1007-1, 51754-1007-3 Strength: 500 mg/10 mL (50 mg/mL) How supplied: 10ml Single Dose glass vial Shelf Pack: 10 vials per carton Orange Book Rating: Description: ...

Usual Adult Dose for: • • • • • • Usual Pediatric Dose for: • • • • Additional dosage information: • • • • • Usual Adult Dose for Metabolic Acidosis Parenteral: If acid-base status is available, dosages should be calculated as follows: 0.2 x weight (kg) x base deficit. Alternatively: HCO3 (mEq) required = 0.5 x weight (kg) x [24 - serum HCO3 (mEq/L)]. or Moderate metabolic acidosis: 50 to 150 mEq sodium bicarbonate diluted in 1 L of D5W to be intravenously infused at a rate of 1 to 1.5 L/hour during the first hour. Severe metabolic acidosis: 90 to 180 mEq sodium bicarbonate diluted in 1 L of D5W to be intravenously infused at a rate of 1 to 1.5 L/hour during the first hour. If acid-base status is not available, dosages should be calculated as follows: 2 to 5 mEq/kg IV infusion over 4 to 8 hours; subsequent doses should be based on patient's acid-base status. Oral: Moderate metabolic acidosis: 325 to 2000 mg orally 1 to 4 times a day. One gram provides 11.9 mEq (mmoL) each of sodium and bicarbonate. Usual Adult Dose for Diabetic Ketoacidosis Although sodium bicarbonate is approved for the treatment of metabolic acidosis, data have shown that the use of this drug may be harmful in certain clinical settings such as lactic acidosis, acidosis with tissue hypoxia, uremia, severe cardiac dysfunction or arrest, and diabetic ketoacidosis. Most experts only allow for its use when tissue perfusion and ventilation are maximized and the arterial pH is 7.1 or lower. If sodium bicarbonat...

When choosing an infiltrative anesthetic agent, the type of procedure, the length of time required for anesthesia, and the pharmacodynamics of each medication are important considerations. Distraction techniques and buffering with sodium bicarbonate can be used to decrease the pain associated with injection. Local cutaneous infiltration is the most commonly used anesthetic technique and involves direct injection into the area requiring anesthesia. Field blocks provide anesthesia by circumferentially blocking innervation to the area. Nerve blocks target the innervation to a specific area and are useful on the face and digits. Using easily identifiable landmarks, blockade of the supraorbital, supratrochlear, infraorbital, and mental nerves can provide site-specific anesthesia. Dorsal and palmar or plantar digital nerve blocks can be performed at a variety of locations on the hands and feet. Clinical recommendation Evidence rating References Lidocaine (Xylocaine) buffered with sodium bicarbonate decreases the pain associated with injection; this effect is enhanced when the solution is warmed to room temperature. B – The intraoral approach to infraorbital or mental nerve blocks reduces patient discomfort. C – Review anatomy and choose an anesthetic technique Consider contraindications Absolute contraindications: patient refusal, infection at injection site, allergy to local anesthetic, nonsterile conditions Relative contraindications: coagulopathy, preexisting neuropathy of th...