Thrombocytosis causes

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DEAR MAYO CLINIC:I am 33 years old and recently had an annual physical and routine blood work. I'm active with two children and feel fantastic, but my platelet count came back as 651. My health care professional said it could indicate a blood cancer and referred me to a hematologist. What can cause my platelets to be so high? I'm nervous, as my only prior medical problem was iron deficiency anemia. ANSWER:Being told you might have cancer can be scary, but, thankfully, most people with an elevated platelet count do not have cancer. Understanding what platelets are can help you understand the situation. Your bone marrow makes white blood cells, red blood cells and platelets. White blood cells help fight infection, red blood cells help carry oxygen to parts of the body, and platelets help keep you from bleeding too much. When a blood vessel is injured, like after a cut, platelets are activated and stick together to plug the hole and stop the bleeding. A normal platelet count typically ranges from 150–450 cells per nanoliter of blood. Like you, most patients with a high platelet count do not have any symptoms, and the high count is found unexpectedly on routine blood work. The referral to a hematologist can help you discern the cause of your high platelet numbers. There are two possible causes: • Essential thrombocytosis • Secondary thrombocytosis Primary thrombocytosis also is technically considered cancer. Patients diagnosed with this are often found to have a mutation in th...

Neutrophilia happens when your body produces too many neutrophils. Neutrophils are a type of white blood cell. They help you fight infection. If there are too many neutrophils in your bloodstream, you may develop leukocytosis, or a high total white blood cell count. You may have symptoms such as fevers or recurring infections. These symptoms may be signs of an underlying condition. Symptoms and Causes What causes neutrophilia? Neutrophilia is your body’s reaction to an assortment of problems, from serious What are primary neutrophilia causes? You can be born with neutrophilia. Other causes include: • • • • Juvenile myelomonocytic leukemia (JMML). This is a rare blood cancer that typically affects children and happens when certain white blood cells don’t mature normally. • Chronic neutrophilic leukemia. This is a rare blood cancer that happens when your bone marrow makes too many neutrophils. What are secondary neutrophilia causes? Secondary neutrophilia causes are linked to various infections, inflammation caused by medical conditions and your body’s reaction to stress. Secondary causes include: • Infection and • Acute chronic inflammation that’s caused by • • Injuries such as breaking a bone. • Reactions to • Reaction to medication. • Physical or • • Vigorous exercise. What’s the difference between neutrophilia and neutropenia? What are neutrophilia symptoms? Neutrophilia itself typically doesn’t have symptoms. A high white blood cell count may be a sign of underlying con...