Vortioxetine

Vortioxetine: 7 things you should know Medically reviewed by • • • • • • • 1. How it works • Vortioxetine may be used to treat depression. • Experts are unsure exactly how vortioxetine works, although historically it was believed that vortioxetine’s effects were due to its ability to rebalance chemicals in the brain, such as serotonin, that were thought to be imbalanced in people with mood disorders. Studies confirm that vortioxetine is still effective for treating mood disorders, such as depression, even though the way it works is unknown. • Vortioxetine has effects on other serotonin receptors, such as 5-HT1A (agonist effects) and 5-HT3 (antagonist effects), but experts are not sure if these actions contribute to vortioxetine’s antidepressant effect. • Vortioxetine is different from other antidepressants currently on the market because of its direct effects on various serotonin receptors as well as inhibiting serotonin reuptake. Because it acts as an antagonist/agonist and partial agonist, this is thought to enhance its antidepressant effects and prevent desensitization of the presynaptic neuron, although the exact way it works is unknown. It aims to reduce depressive symptoms and prevent them from returning. • Vortioxetine is classified as a miscellaneous antidepressant, although some classify it as an SSRI (selective serotonin reuptake inhibitor) and a serotonin receptor modulator. 2. Upsides • Vortioxetine may be used to treat major depressive disorder (MDD) in adults...

Description and Brand Names Drug information provided by: US Brand Name • Trintellix Descriptions Vortioxetine is used to treat major depressive disorder (MDD). It is an antidepressant and belongs to a group of medicines known as selective serotonin reuptake inhibitors (SSRIs). Vortioxetine works by increasing the activity of a chemical called serotonin in the brain. This medicine is available only with your doctor's prescription. This product is available in the following dosage forms: • Tablet • Portions of this document last updated: June 01, 2023 Copyright: © Merative US L.P. 1973, 2023. All rights reserved. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes. • •

Before taking this medicine You should not use vortioxetine if you are allergic to it. Do not use vortioxetine if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include After you stop taking vortioxetine you must wait at least 21 days before you start taking an MAO inhibitor. Tell your doctor if you also take stimulant medicine, opioid medicine, Tell your doctor if you have ever had: • • • • bleeding problems; or • low levels of sodium in your blood. Some young people have thoughts about suicide when first taking an antidepressant. Your doctor should check your progress at regular visits. Your family or other caregivers should also be alert to changes in your mood or symptoms. Not approved for use by anyone younger than 18 years old. Taking vortioxetine in the last 3 months of pregnancy may cause problems in the newborn, such as withdrawal symptoms, serious lung problems, or other complications in the baby. However, stopping the medicine may not be safe for you. Do not start or stop vortioxetine without asking your doctor. Ask a doctor if it is safe to breastfeed while using vortioxetine. How should I take vortioxetine? Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed. You may take vortioxetine with or without food. You may have withdrawal symptoms if you stop using vortioxeti...

International Journal of Neuropsychopharmacology suggest. The findings indicate that depressive and cognitive symptoms may be mediated by different receptors and brain chemicals. Vortioxetine seems to work independently in both domains. 2 “Vortioxetine differs from selective serotonin reuptake inhibitors [SSRIs] in its multimodal effect on serotonin transport and reuptake,” said study researcher Roger S. McIntyre, MD, FRCP, a professor of psychiatry at the University of Toronto in Ontario, Canada, and Psychiatry Advisor editorial board member. “Vortioxetine may also affect a variety of other neurotransmitters. The relevance is that it’s the first antidepressant to affect the domain of cognition independently, a domain we struggle to treat well in depression.” Vortioxetine received FDA approval for the treatment of major depressive disorder in 2013. The drug is an SSRI, but it also acts as a 5HT agonist, antagonist, and transport inhibitor. 3 “We do not know exactly how vortioxetine mediates cognition, but it may be as a receptor antagonist at 5HT3 and 7, where it may impact neurotransmitters like glutamine and acetylcholine that are intimately involved in regulation of cognitive function,” said McIntyre. The eight-week, double-blind, multinational study compared the efficacy of vortioxetine at 10mg and 20mg per day against placebo on both cognition and depression in 602 adults with MDD aged 18 to 65 years. Both doses of vortioxetine significantly improved cognition scores ...

Read the Take this medication by To reduce your risk of side effects, your doctor may direct you to start this medication at a low dose and gradually increase your dose. Follow your doctor's instructions carefully. Do not increase your dose or use this drug more often or for longer than prescribed. Your condition will not improve any faster, and your risk of side effects will increase. Use this medication regularly to get the most benefit from it. To help you remember, take it at the same time each day. Keep taking this medication even if you feel well. Do not stop taking this medication without consulting your doctor. Some conditions may become worse when this drug is suddenly stopped. Also, you may experience symptoms such as mood swings, It may take up to several weeks before you get the full benefit of this drug. Tell your doctor if your condition does not improve or if it worsens. See also Warning section. Remember that this Tell your doctor right away if you have any serious side effects, including: shaking (tremor), restlessness, inability to keep still, changes in sexual ability, decreased interest in sex, numbness/tingling, easy bleeding/bruising, difficulty concentrating, memory changes, confusion, Get medical help right away if you have any very serious side effects, including: This medication may increase serotonin and rarely cause a very serious condition called A very serious This is not a complete list of possible side effects. If you notice other effects no...

Contraindications [ ] Vortioxetine is Adverse effects [ ] Side effects of vortioxetine at different doses in clinical trials Side effect Placebo Vortioxetine Duloxetine 5mg/day 10mg/day 15mg/day 20mg/day 60mg/day Any 62% 66% 67% 70% 73% 77% 9% 21% 26% 32% 32% 36% 1% 3% 5% 6% 6% 4% 6% 7% 7% 10% 7% ? 3% 3% 5% 6% 6% 10% 6% 7% 7% 6% 8% ? 1% 1% 3% 2% 1% ? 6% 6% 6% 8% 9% ? 1% 1,000nM) (including e.g. the DAT). Sources: Vortioxetine increases 1A receptor, 1B receptor, and 1D, 3, and 7 receptors, as well as an apparent 1-adrenergic receptor. 3 receptor antagonism than for its interactions with the other serotonin receptors. 50 or 50 values of 5.4nM for the SERT and 12nM for the 5-HT 3 receptor, its values are 120 to 450nM for the 5-HT 1A, 5-HT 1B, 5-HT 1D, and 5-HT 7 receptors. 3 antagonism over activities at the other serotonin receptors. It has been claimed that the 3 receptor may be primarily occupied at lower clinical doses of vortioxetine and that the 5-HT 1B, 5-HT 1A, and 5-HT 7 receptors may additionally be occupied at higher doses. Based on its clinical efficacy (e.g., at 5mg/day), 1A receptor with vortioxetine at 30mg/day for 9days, which suggests that at least this specific serotonin receptor may not be involved in the clinical pharmacology of vortioxetine. 3 and 5-HT 7 by vortioxetine in humans does not seem to have been studied. Antagonism of the 5-HT 3 receptor has been found to enhance the increase in brain serotonin levels produced by serotonin reuptake inhibition i...