Where does atp synthesis occur in mitochondria

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Mitochondria are cellular organelles responsible for generation of chemical energy in the process called oxidative phosphorylation. They originate from a bacterial ancestor and maintain their own genome, which is expressed by designated, mitochondrial transcription and translation machineries that differ from those operating for nuclear gene expression. In particular, the mitochondrial protein synthesis machinery is structurally and functionally very different from that governing eukaryotic, cytosolic translation. Despite harbouring their own genetic information, mitochondria are far from being independent of the rest of the cell and, conversely, cellular fitness is closely linked to mitochondrial function. Mitochondria depend heavily on the import of nuclear-encoded proteins for gene expression and function, and hence engage in extensive inter-compartmental crosstalk to regulate their proteome. This connectivity allows mitochondria to adapt to changes in cellular conditions and also mediates responses to stress and mitochondrial dysfunction. With a focus on mammals and yeast, we review fundamental insights that have been made into the biogenesis, architecture and mechanisms of the mitochondrial translation apparatus in the past years owing to the emergence of numerous near-atomic structures and a considerable amount of biochemical work. Moreover, we discuss how cellular mitochondrial protein expression is regulated, including aspects of mRNA and tRNA maturation and stabil...

Every living organism consists of cells that rely on ATP for their energy needs. ATP is made by converting the food we eat into energy. It's an essential building block for all life forms. Without ATP, cells wouldn't have the fuel or power to perform functions necessary to stay alive, and they would eventually die. All forms of life rely on ATP to do the things they must do to survive. NANOCLUSTERING/SCIENCE PHOTO LIBRARY / Getty Images How ATP Works ATP is made of a nitrogen base (adenine) and a sugar molecule (ribose), which create adenosine, plus three phosphate molecules. If adenosine only has one phosphate molecule, it’s called adenosine monophosphate (AMP). If it has two phosphates, it’s called adenosine diphosphate (ADP). ATP was first discovered in the 1920s. In 1929, Karl Lohmann—a German chemist studying muscle contractions—isolated what we now call adenosine triphosphate in a laboratory. At the time, Lohmann called ATP by a different name. It wasn't until a decade later, in 1939, that Nobel Prize–winner Fritz Lipmann established that ATP is the universal carrier of energy in all living cells and coined the term "energy-rich phosphate bonds." Lipmann focused on phosphate bonds as the key to ATP being the universal energy source for all living cells, because adenosine triphosphate releases energy when one of its three phosphate bonds breaks off to form ADP. ATP is a high-energy molecule with three phosphate bonds; ADP is low-energy with only two phosphate bonds. A...