Write about therapeutic indication for atorvastatin

DESCRIPTION Potent HMG-CoA reductase inhibitor Used to treat hypercholesterolemia and hypertriglyceridemia, to prevent cardiovascular events in patients at risk for CHD or with clinical evidence of CHD, and for homozygous familial hypercholesterolemia; reduces LDL cholesterol, apoprotein B, and triglycerides; increases HDL Has a long half-life and high hepatic selectivity Adults 10 to 20 mg PO once daily initially. May start at 40 mg PO once daily in patients requiring greater than 45% LDL-reduction. The dosage range is 10 to 80 mg PO once daily (mean LDL reduction range: 43% to 60% LDL). The daily dose may be given at any time during the day. After atorvastatin initiation, assess LDL-C levels as early as 4 weeks or when clinically appropriate and adjust dosage as necessary. In general, geriatric patients may have an increased cholesterol-lowering response to HMG-CoA reductase inhibitors. Coadministration of certain drugs with atorvastatin may need to be avoided or dosage adjustments may be necessary; review drug interactions. Children and Adolescents 10 years and older (females should be at least 1 year post-menarche) 10 mg PO once daily initially. The dosage range is 10 to 20 mg PO once daily. The daily dose may be given at any time during the day. After atorvastatin initiation, assess LDL-C levels as early as 4 weeks or when clinically appropriate and adjust dosage as necessary.[28729] In a randomized, placebo-controlled trial of pediatric patients with familial hyperch...

• Muscle problems warning: Your risk for myopathy (muscle pain, tenderness, or weakness) and rhabdomyolysis (muscle breakdown) is increased while taking atorvastatin. The risk is greater if you’re a senior, have thyroid problems, or have kidney disease. Tell your doctor right away if you start to have unexplained muscle soreness, pain, or weakness. • Liver problems warning: Lab tests for your liver may be abnormally high while you’re taking atorvastatin and you may have liver problems. Your doctor will monitor this while you’re taking this drug. • Increased blood sugars warning: Atorvastatin may increase your blood sugar levels. You and your doctor should monitor your blood sugar levels carefully while you’re taking this drug. Atorvastatin oral tablet is a prescription drug. It’s available as a brand-name drug called Lipitor. It’s also available in a generic form. Generic drugs usually cost less than the brand-name version. In some cases, they may not be available in all strengths or forms as the brand-name drug. Why it’s used Atorvastatin is used to improve cholesterol levels in people with different types of cholesterol problems. It’s also used to decrease your risk for heart attack and stroke. It’s used together with diet, weight loss, and exercise. Atorvastatin helps to prevent cholesterol from building up in your arteries. Clogged arteries can block blood flow to your heart and brain. Atorvastatin may be used as part of a combination therapy. This means you may need t...

• Health Topics • Developmental Pediatrics • General Pediatrics • Genetics • Immunodeficiencies • Infectious Diseases • Laboratory Medicine • Neonatology • Nutrition • Pediatric Cardiology • Pediatric Dermatology • • Featured Articles • Diabetic ketoacidosis • Penile hygiene • Circumcision • Skin allergies • Anal fissure • Anal itching • Kids Corner Health and Knowledge with fun. • • Calculators • Medical Calculators • Drug Calculators • Genetic Calculators • Growth Calculators • • Drug Index • ACE inhibitor • Alkylating agents • Allergies • • Poisoning Center • Aluminum phosphide • Anti-histaminics • Antidepressants • • Medical Eqipments • Monitors • Pumps • Incubators • • Diagnostic Aid Get your diffrential diagnosis. • • & Posts Atorvastatin Mechanism : Atorvastatin is a synthetic lipid-lowering agent. Atorvastatin is an inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase. This enzyme catalyzes the conversion of HMG-CoA to mevalonate, an early and rate-limiting step in cholesterol biosynthesis. Indication : • Hyperlipidemia Contraindications : Hypersensitivity to any component of this medication. Active liver disease or unexplained persistent elevations of serum transaminases exceeding 3 times the upper limit of normal. Dosing : Initial: 10 mg/day (Oral), titrate at 4-week intervals; the maximum recommended dose is 20 mg/day. May increase upto 40 mg/day in patients with homozygous familial hypercholesterolemia. Adverse Effect : Diarrhea, arthralgia, i...

Read the Patient Information Leaflet if available from your Take this The dosage is based on your medical condition, response to treatment, age, and other Shake the bottle well before each dose. Carefully measure the dose using a special measuring device/spoon. Do not use a household spoon because you may not get the correct dose. Avoid eating grapefruit or drinking grapefruit juice while using this medication unless your doctor or pharmacist says you may do so safely. Grapefruit can increase the chance of side effects with this medicine. Ask your doctor or pharmacist for more details. If you also take certain other drugs to lower your cholesterol (bile acid-binding resins such as Take this medication regularly in order to get the most benefit from it. Remember to take it at the same time each day. Keep taking this medication even if you feel well. Most people with It is very important to continue to follow your doctor's advice about Remember that this A very small number of people taking Rarely, This drug may rarely cause muscle problems (which can rarely lead to very serious conditions called This medication may rarely cause A very serious This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or In the US - Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch. In Canada - Call your doctor for medical advice about side effect...

Atorvastatin Oral Suspension is indicated as an adjunct to diet for reduction of elevated total cholesterol (Total-C), LDL-cholesterol (LDL-C), apolipoprotein B, and triglycerides in adults, adolescents and children aged 10 years or older with primary cholesterolaemia including familial hypercholesterolaemia (heterozygous variant) or combined (mixed) hyperlipidaemia (Corresponding to Types IIa and IIb of the Frederickson classification) when response to diet and other nonpharmacological measures is inadequate. Atorvastatin is also indicated to reduce total-C and LDL-C in adults with homozygous familial hypercholesterolaemia as an adjunct to other lipid-lowering treatments (e.g. LDL apheresis) or if such treatments are unavailable.

The American College of Cardiology/American Heart Association (ACC/AHA) task force on clinical practice guidelines has updated its 2013 cholesterol guideline. The 2018 guideline narrows the use of the atherosclerotic cardiovascular disease (ASCVD) risk calculator, provides more guidance on the use of risk-enhancing factors in making statin therapy decisions, and recommends therapy options for achieving low-density lipoprotein cholesterol (LDL-C) targets. The updated guideline also includes recommendations for nonstatin lipid-lowering agents that can be used as statin add-ons to meet recommended LDL-C thresholds. A cornerstone of the guideline is to emphasize a heart-healthy lifestyle for all patients. A healthy lifestyle reduces ASCVD risk at all ages and can reduce the development of risk factors in younger patients. Based on moderate-quality evidence from nonrandomized trials, measuring fasting or nonfasting plasma lipid levels is effective in estimating ASCVD risk and documenting baseline LDL-C in adults 20 years and older who are not on lipid-lowering therapy. When an initial nonfasting lipid profile reveals a triglyceride level of 400 mg per dL (4.5 mmol per L) or greater, a repeat lipid profile should be obtained to assess fasting triglyceride and baseline LDL-C levels in adults 20 years and older. Based on high-quality evidence from randomized controlled trials (RCTs), high-intensity statin therapy should be instituted with a goal of lowering LDL-C levels by 50% or ...

Latest prescription information about Atorvastatin. Learn how to pronounce the drug's name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, warnings and its storage instructions . Also listed are the International and Indian trade name(s) of the drug and its price list. What are the warnings and precautions for Atorvastatin? • Caution should be exercised in patients with history of low blood pressure, serious infection, seizures, electrolyte problems, liver problems, alcohol abuse, any allergy, during pregnancy and breastfeeding. • It may cause dizziness, do not drive a car or operate machinery while taking this medication. • Avoid alcohol consumption. • Follow the diet and exercise program as directed by your physician. • Monitor blood cholesterol level and liver functions regularly while taking this medication. What are the side effects of Atorvastatin? • Most Common : Nose inflammation, joint pain, diarrhea, pain in extremity, urinary tract infection, indigestion, nausea, muscle and bone pain, muscle spasms, sleeplessness and throat pain. • Body as a whole : Uneasiness and fever. • Gastrointestinal : Abdominal discomfort, eructation, flatulence, liver inflammation and bile obstruction. • Musculoskeletal : Muscle fatigue, neck pain and joint swelling. • Metabolic : Increase in liver enzymes level, abnormal liver function tests and increased sugar level. • Central Nervous system : Dizziness, depression, fatigue, per...

Caduet, Lipitor, Lypqozet Generic Name Atorvastatin DrugBank Accession Number DB01076 Background Atorvastatin (Lipitor®), is a lipid-lowering drug included in the statin class of medications. By inhibiting the endogenous production of cholesterol in the liver, statins lower abnormal cholesterol and lipid levels, and ultimately reduce the risk of cardiovascular disease. More specifically, statin medications competitively inhibit the enzyme hydroxymethylglutaryl-coenzyme A (HMG-CoA) Reductase, Atorvastatin and other statins including Atorvastatin was first synthesized in 1985 by Dr. Bruce Roth and approved by the FDA in 1996. Type Small Molecule Groups Approved Structure Pharmacology Indication Atorvastatin is indicated for the treatment of several types of dyslipidemias, including primary hyperlipidemia and mixed dyslipidemia in adults, hypertriglyceridemia, primary dysbetalipoproteinemia, homozygous familial hypercholesterolemia, and heterozygous familial hypercholesterolemia in adolescent patients with failed dietary modifications. Dyslipidemia describes an elevation of plasma cholesterol, triglycerides or both as well as to the presence of low levels of high-density lipoprotein. This condition represents an increased risk for the development of atherosclerosis. Atorvastatin is indicated, in combination with dietary modifications, to prevent cardiovascular events in patients with cardiac risk factors and/or abnormal lipid profiles. Atorvastatin can be used as a preventive...

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The American College of Cardiology/American Heart Association (ACC/AHA) task force on clinical practice guidelines has updated its 2013 cholesterol guideline. The 2018 guideline narrows the use of the atherosclerotic cardiovascular disease (ASCVD) risk calculator, provides more guidance on the use of risk-enhancing factors in making statin therapy decisions, and recommends therapy options for achieving low-density lipoprotein cholesterol (LDL-C) targets. The updated guideline also includes recommendations for nonstatin lipid-lowering agents that can be used as statin add-ons to meet recommended LDL-C thresholds. A cornerstone of the guideline is to emphasize a heart-healthy lifestyle for all patients. A healthy lifestyle reduces ASCVD risk at all ages and can reduce the development of risk factors in younger patients. Based on moderate-quality evidence from nonrandomized trials, measuring fasting or nonfasting plasma lipid levels is effective in estimating ASCVD risk and documenting baseline LDL-C in adults 20 years and older who are not on lipid-lowering therapy. When an initial nonfasting lipid profile reveals a triglyceride level of 400 mg per dL (4.5 mmol per L) or greater, a repeat lipid profile should be obtained to assess fasting triglyceride and baseline LDL-C levels in adults 20 years and older. Based on high-quality evidence from randomized controlled trials (RCTs), high-intensity statin therapy should be instituted with a goal of lowering LDL-C levels by 50% or ...