10 functions of the liver

In this blog, I will give information regarding functions of First, I am giving some basic information regarding Liver. It is located in the upper & right side of abdominal cavity, immediately beneath diaphragm. Weight of liver is approx 1.5 kg. It is largest gland in the body. Liver is a dual organ having both secretory and excretory function. Total number of liver functions are more than 500. Here, I mentioned 10 vital functions. We can not believe our life without working of liver. 7 Hemopoietic function Heme = blood Poiesis = to make So, this function means liver makes blood. • • • • In foetus(intrauterine life) liver produces the blood cells. • It store vit B12 necessary for erythropoiesis. • It store Iron necessary for synthesis of Hemoglobin. • Liver produces thrombopoietin that promotes production of platelets.

Bader Alabdulaali 1,2‡, Fatema Al-rashed 1, Mohammed Al-Onaizi 3,1, Anwar Kandari 1,2, Joanna Razafiarison 4, Dorothy Tonui 4, Michayla R. Williams 1, Camille Blériot 4,5, Rasheed Ahmad 1 and Fawaz Alzaid 1,4* • 1Dasman Diabetes Institute, Kuwait City, Kuwait • 2Ministry of Health, Kuwait City, Kuwait • 3Department of Anatomy, Faculty of Medicine, Kuwait University, Kuwait City, Kuwait • 4INSERM UMR-S1151, CNRS UMR-S8253, Université Paris Cité, Institut Necker Enfants Malades, Paris, France • 5Inserm U1015, Gustave Roussy, Villejuif, France The liver is the site of first pass metabolism, detoxifying and metabolizing blood arriving from the hepatic portal vein and hepatic artery. It is made up of multiple cell types, including macrophages. These are either bona fide tissue-resident Kupffer cells (KC) of embryonic origin, or differentiated from circulating monocytes. KCs are the primary immune cells populating the liver under steady state. Liver macrophages interact with hepatocytes, hepatic stellate cells, and liver sinusoidal endothelial cells to maintain homeostasis, however they are also key contributors to disease progression. Generally tolerogenic, they physiologically phagocytose foreign particles and debris from portal circulation and participate in red blood cell clearance. However as immune cells, they retain the capacity to raise an alarm to recruit other immune cells. Their aberrant function leads to the development of non-alcoholic fatty liver disease (NAFLD). N...