Cyproheptadine hydrochloride

Cyproheptadine is used to treat allergic reactions (specifically It is also used as a preventive treatment against It is also used off-label in the treatment of Cyproheptadine is sometimes used off-label to improve It is used off-label to treat various dermatological conditions, including One of the effects of the drug is increased It is also used off-label in the management of moderate to severe cases of Cyproheptadine has sedative effects and can be used to treat insomnia similarly to other centrally-acting antihistamines. Adverse effects [ ] Adverse effects include: • Sedation and sleepiness (often transient) • Dizziness • Disturbed coordination • Confusion • Restlessness • Excitation • Nervousness • Tremor • Irritability • Insomnia • Paresthesias • Neuritis • Convulsions • Euphoria • Hallucinations • Hysteria • Faintness • Allergic manifestation of rash and edema • Diaphoresis • Urticaria • Photosensitivity • Acute labyrinthitis • Diplopia (seeing double) • Vertigo • Tinnitus • Hypotension (low blood pressure) • Palpitation • Extrasystoles • Anaphylactic shock • Hemolytic anemia • Blood dyscrasias such as • Cholestasis • Hepatic (liver) side effects such as: • • • • Hepatic function abnormality • • • Nausea • Vomiting • Diarrhea • • Blurred vision • Constipation • Xerostomia (dry mouth) • Tachycardia (high heart rate) • Urinary retention • Difficulty passing urine • Nasal congestion • Nasal or throat dryness • Urinary frequency • Early menses • Thickening of bronchial ...

Pharmacology Mechanism of Action A potent antihistamine and serotonin antagonist with anticholinergic effects; competes with histamine for H 1-receptor sites on effector cells in the gastrointestinal tract, blood vessels, and respiratory tract (Paton 1985). Pharmacokinetics/Pharmacodynamics Absorption Well absorbed (Graudins 1998) Metabolism Primarily by hepatic glucuronidation to metabolites (Hintze 1975) Excretion Urine (~40% primarily as metabolites); feces (2% to 20%, 9 years showed a greater response than younger patients as did patients with hematologic malignancies (Couluris 2008). Fixed dosing: Children ≥5 years and Adolescents: Initial: 2 mg every 6 hours (4 times daily) for 1 week; if tolerated, increase dose to 4 mg every 6 hours; dosing based on a short-term (12-week) double-blind, placebo-controlled trial (n=8 treatment group) and a long-term (1-year) open-label trial (n=12) in cystic fibrosis patients; results showed significant increases in weight gain (3.4 kg vs 1.1 kg in placebo); long-term results showed a generally sustained effect (eg, no further weight loss or some additional weight gain) over study duration (Homnick 2004; Homnick 2005). Cyclic vomiting syndrome; prevention: Limited data available: Oral: Children 2 to 5 years: 0.25 to 0.5 mg/kg/day in divided doses 2 to 3 times daily; maximum daily dose: 12 mg/ day; some clinicians have used once daily dose at bedtime to prevent day time sedation (Andersen 1997; Li 2008) Dyspeptic syndrome; refractory:...

Cyproheptadine is an antihistamine medication. It blocks the action of certain chemical messengers that are responsible for inflammation, congestion, itching, and other allergic reactions. Due to constant increased energy intake and stimulation of growth hormone secretion, it stimulates the appetite too.

Usual Adult Dose for: • • • • • • • Usual Pediatric Dose for: • • • • • • • Additional dosage information: • • • • • Usual Adult Dose for Allergic Reaction Initial dose: 4 mg orally 3 times a day Maintenance dose: 4 to 20 mg orally per day, given in divided doses Maximum dose: 0.5 mg/kg/day Comments: • Doses should be individualized, with doses based on response and patient size. • Many patients require a daily dose of 12 to 16 mg. • Some patients need up to 32 mg/day to attain relief. Uses: • Adjunctive agent to epinephrine and other standard measures AFTER acute anaphylactic reaction manifestations have been controlled • Allergic conjunctivitis due to inhalant allergens and foods • Amelioration of allergic reactions to blood or plasma • Cold urticaria • Dermatographism • Mild, uncomplicated allergic skin manifestations of angioedema and urticaria • Perennial/seasonal allergic rhinitis • Vasomotor rhinitis Usual Adult Dose for Allergic Rhinitis Initial dose: 4 mg orally 3 times a day Maintenance dose: 4 to 20 mg orally per day, given in divided doses Maximum dose: 0.5 mg/kg/day Comments: • Doses should be individualized, with doses based on response and patient size. • Many patients require a daily dose of 12 to 16 mg. • Some patients need up to 32 mg/day to attain relief. Uses: • Adjunctive agent to epinephrine and other standard measures AFTER acute anaphylactic reaction manifestations have been controlled • Allergic conjunctivitis due to inhalant allergens and foods • ...

Cyproheptadine Syrup Description Each 5 mL (one teaspoonful) contains: cyproheptadine hydrochloride 2 mg Inactive ingredients: alcohol 5% (v/v), citric acid, D&C Yellow #10, butylated hydroxyanisole, peppermint flavor, sucralose, propylene glycol, purified water, sodium citrate, sorbic acid (0.1%, as preservative). Cyproheptadine Hydrochloride is an antihistaminic and antiserotonergic agent. Cyproheptadine hydrochloride is a white to slightly yellowish, crystalline solid, with a molecular weight of 350.88, which is slightly soluble in water, freely soluble in methanol, sparingly soluble in ethanol, soluble in chloroform and practically insoluble in ether. It is the sesquihydrate of 4-( 5H-Dibenzo [ a,d]cyclohepten-5-ylidene)-1-methylpiperidine hydrochloride. The molecular formula of the anhydrous salt is C 21H 21N • HCl and the structural formula of the anhydrous salt is: Related/similar drugs Cyproheptadine Syrup - Clinical Pharmacology Cyproheptadine is a serotonin and histamine antagonist with anticholinergic and sedative effects. Antiserotonin and antihistamine drugs appear to compete with serotonin and histamine, respectively, for receptor sites. Pharmacokinetics and Metabolism: After a single 4 mg oral dose of 14C-labeled cyproheptadine hydrochloride in normal subjects, given as tablets or syrup, 2-20% of the radioactivity was excreted in the stools. Only about 34% of the stool radioactivity was unchanged drug, corresponding to less than 5.7% of the dose. At least 40...

Shop for your own coverage Medical Dental Other Supplemental Plans through your employer Learn about the medical, dental, pharmacy, behavioral, and voluntary benefits your employer may offer. Explore coverage through work Learn How to Buy Health Insurance Types of Dental Insurance Open Enrollment vs. Special Enrollment See all topics Looking for Medicare coverage? Shop for Medicare plans You should not use cyproheptadine if you have narrow-angle glaucoma, a stomach ulcer or obstruction, an enlarged prostate, urination problems, or if you are having an asthma attack. You also should not use cyproheptadine if you are breast-feeding a baby, if you are elderly, or if you have a debilitating disease. Do not use this medicine if you have used an MAO inhibitor in the past 14 days, such as isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, or tranylcypromine. What is cyproheptadine? Cyproheptadine is an antihistamine that reduces the effects of natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose. Cyproheptadine is used to treat sneezing, runny nose, itching, red or watery eyes, and other symptoms of seasonal allergies (hay fever). Cyproheptadine is also used to treat other conditions such as eczema or skin reactions to insect bites. Cyproheptadine is sometimes used to treat certain types of headaches, including migraines. Cyproheptadine may also be used for purposes not listed...

Cyproheptadine is an antihistamine used to relieve allergy symptoms such as watery eyes, runny nose, itching eyes/nose, sneezing, hives, and itching. It works by blocking a certain natural substance (histamine) that your body makes during an allergic reaction. This medication also blocks another natural substance in your body (serotonin). This medication should not be used in newborn or premature infants. How to use Take this medication by mouth with or without food as directed by your doctor, usually 2 to 3 times a day. If you are using the liquid form of this medication, carefully measure the dose using a special measuring device/spoon. Do not use a household spoon because you may not get the correct dose. The dosage is based on your age, medical condition, and response to treatment. In children, the dosage may also be based on weight and body size. Do not increase your dose or take this medication more often than directed. Tell your doctor if your condition does not improve or if it worsens. Side effects Drowsiness, dizziness, blurred vision, constipation, or dry mouth/nose/throat may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly. To relieve dry mouth, suck (sugarless) hard candy or ice chips, chew (sugarless) gum, drink water, or use a saliva substitute. Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medi...