Deflazacort tablet uses

Metoject, Nordimet, Otrexup, Rasuvo, Reditrex, Trexall, Xatmep Generic Name Methotrexate DrugBank Accession Number DB00563 Background Methotrexate is a folate derivative that inhibits several enzymes responsible for nucleotide synthesis. Due to the toxic effects of methotrexate, it is indicated for treatment of some forms of arthritis and severe psoriasis only if first line treatment has failed or patients are intolerant of those treatments. Methotrexate was granted FDA approval on 7 December 1953. Type Small Molecule Groups Approved Structure • CL 14377 • CL-14377 • EMT 25299 • EMT-25299 • NSC-740 • R 9985 • R-9985 Pharmacology Indication Methotrexate oral solution is indicated for pediatric acute lymphoblastic leukemia and pediatric polyarticular juvenile idiopathic arthritis. Other formulations are indicated to treat gestational choriocarcinoma, chorioadenoma destruens, hydatiform mole, breast cancer, epidermoid cancer of the head and neck, advanced mycosis fungoides, lung cancer, and advanced non-Hodgkin's lymphoma. Learn more Pharmacodynamics Methotrexate inhibits enzymes responsible for nucleotide synthesis which prevents cell division and leads to anti-inflammatory actions. Do not take methotrexate daily. Mechanism of action Methotrexate enters tissues and is converted to a methotrexate polyglutamate by folylpolyglutamate. Methotrexate's mechanism of action is due to its inhibition of enzymes responsible for nucleotide synthesis including dihydrofolate reductase, th...

Deflazacort (Monograph) Brand name: Drug class: Adrenals Chemical name: (11β,16β)-21-(Acetyloxy)-11-hydroxy-2′-methyl-5′H-pregna-1,4-dieno[17,16-d]oxazole-3,20-dione Molecular formula: C 25H 31NO 6 CAS number: 14484-47-0 • • • • • • • Introduction Synthetic corticosteroid. Uses for Deflazacort Duchenne Muscular Dystrophy Management of Duchenne muscular dystrophy (designated an orphan drug by FDA for use in this condition). Current standard of care for patients with Duchenne muscular dystrophy includes the use of corticosteroids for improving muscle function and strength. The American Academy of Neurology recommends prednisone or deflazacort to improve muscle strength, pulmonary function, and possibly also slow the development of scoliosis and need for surgery. Deflazacort Dosage and Administration General • Patients receiving corticosteroid therapy may require higher dosages of corticosteroids when subjected to stress (e.g., infection, surgery, trauma). • When discontinuing deflazacort therapy after the drug has been given for more than a few days, taper dosage gradually to minimize potential for adrenal insufficiency. (See Adrenal Insufficiency under Cautions.) Administration Oral Administration Administer orally (as tablets or oral suspension) once daily without regard to food. Oral suspension is bioequivalent to the tablets. Oral Suspension Shake well prior to administration. Administer only with the dosing device supplied by manufacturer. Withdraw appropriate dose and ...

Defal 6 Tablet Defal 6 provides anti-inflammatory action by inhibiting Phospholipase A2 enzyme which is responsible for prostaglandin synthesis. Besides Defal 6 decreases the release of certain chemicals that are important in the immune system. By decreasing the release of these chemicals Defal 6 provides immunosuppressive action. Defal 6 exerts anti-inflammatory activity in DMD, likely improving various symptoms, including muscle weakness and cardiorespiratory symptoms in addition to delaying their onset. This allows for an increased quality of life and prevents the necessity for surgical procedures, such as those for scoliosis, which is associated with DMD. Studies showed significant preservation of muscle mass in patients generally treated with 0.9 mg/kg/day of deflazacort compared to a control group. The following findings are based on clinical studies using deflazacort on a long term basis: Effects on muscle strength At age 16, individuals treated with long-term deflazacort had 63 ± 4% score in muscle strength compared to a mean muscle strength score of 31 ± 3% for control patients. Significant improvements in climbing stairs and rising from a supine position were also seen in patients taking deflazacort. Uses • Anaphylaxis, asthma, severe hypersensitivity reactions • Rheumatoid arthritis, juvenile chronic arthritis, polymyalgia rheumatica • Systemic lupus erythematosus, dermatomyositis, mixed connective tissue disease (other than systemic sclerosis), polyarteritis no...

Usual Adult Dose for: • Usual Pediatric Dose for: • Additional dosage information: • • • • • • Usual Adult Dose for Muscular Dystrophy Approximately 0.9 mg/kg orally once a day Comments: • If tablets are used, rounding up to the nearest possible dose is recommended. • If the oral suspension is used, rounding up to the nearest tenth of a mL is recommended. • If this drug has been administered for more than a few days, the dosage should be decreased gradually. Use: For the treatment of Duchenne muscular dystrophy (DMD) Usual Pediatric Dose for Muscular Dystrophy 2 years or older: Approximately 0.9 mg/kg orally once a day Comments: • If tablets are used, rounding up to the nearest possible dose is recommended. • If the oral suspension is used, rounding up to the nearest tenth of a mL is recommended. • If this drug has been administered for more than a few days, the dosage should be decreased gradually. Use: For the treatment of DMD Renal Dose Adjustments Mild, moderate, or severe renal dysfunction: No adjustment recommended Liver Dose Adjustments Mild or moderate liver dysfunction: No adjustment recommended Severe liver dysfunction: Data not available Comments: • No dosing recommendation can be provided for patients with severe liver dysfunction as there is no clinical experience in these patients. Dose Adjustments Use with moderate or strong CYP450 3A4 inhibitors: One-third of the recommended dosage should be used. Use with moderate or strong CYP450 3A4 inducers: Not recomme...

Dosage Forms & Strengths tablet • 6mg • 18mg • 30mg • 36mg oral suspension • 22.75mg/mL Duchenne Muscular Dystrophy Indicated for Duchenne muscular dystrophy (DMD) 0.9 mg/kg/day PO qDay If tablets are used, round up to the nearest possible dose; may use any combination of tablet strengths to achieve calculated dose If the oral suspension is used, round up to the nearest tenth of a milliliter (mL) When discontinuing treatment, gradually decrease dose if administered for more than a few day Dosage Modifications Coadministration with CYP3A4 inhibitors • Moderate or strong CYP3A4 inhibitors: Give one third the recommended deflazacort dose • Example: Reduce a 36-mg/day dose to 12 mg/day when used with moderate or strong CYP3A4 inhibitors Coadministration with CYP3A4 inducers • Moderate or strong CYP3A4 inducers: Avoid use Renal impairment • Mild, moderate, or severe: No dose adjustment required Hepatic impairment • Mild or moderate: No dose adjustment required • Severe: Not studied Dosing Considerations Assessments before initiating treatment • Administer all immunizations according to immunization guidelines • Administer live-attenuated or live vaccines at least 4-6 weeks before starting treatment Dosage Forms & Strengths tablet • 6mg • 18mg • 30mg • 36mg oral suspension • 22.75mg/mL Duchenne Muscular Dystrophy Indicated for treatment of Duchenne muscular dystrophy (DMD) in patients aged ≥2 years <2 years: Safety and efficacy not established ≥2 years • 0.9 mg/kg/day PO qDay • ...

Defcort 6 Tablet belongs to a group of medicines called steroids. It is used for the treatment of various diseases and conditions such as inflammatory conditions, autoimmune conditions, and cancer. Defcort 6 Tablet works by inhibiting the release of substances that cause swelling or by changing how the immune system works. It can be taken on an empty stomach or after food. Taking the medicine regularly at the right times increases its effectiveness. It is important to keep taking the medicine regularly until your doctor tells you it is safe to stop. Use of this medicine may cause some common side effects such as increased appetite, weight gain, frequent urge to urinate, Cushing syndrome, cough, upper respiratory tract infection, abnormal hair growth, obesity, and nasopharyngitis. If any of these side effects bother you, let your doctor know. Defcort 6 Tablet can make it harder for you to fight off infections. Tell your doctor if you have any signs of infection such as a fever or sore throat. Before taking the medicine, you should let your doctor know of all the other medicines you are taking. Pregnant and breastfeeding women should consult their doctors before taking the medicine. Defcort 6 Tablet gives relief in inflammatory conditions that affect muscles and joints such as arthritis and ankylosing spondylitis. It also helps manage other inflammatory conditions such as asthma, inflammatory bowel disease, uveitis, ulcerative colitis, and allergies. It works by blocking cer...