Diethylcarbamazine citrate

Diethylcarbamazine (Oral) Generic name: diethylcarbamazine [ dye-eth-il-kar-BAM-a-zeen] • • Uses for diethylcarbamazine Diethylcarbamazine is used in the treatment of certain worm infections. This medicine works by killing the worms. It is used to treat: • Bancroft's filariasis; • Eosinophilic lung (tropical pulmonary eosinophilia; tropical eosinophilia); • Loiasis; and • River blindness (onchocerciasis). It will not work for other kinds of worm infections (for example, pinworms or tapeworms). Diethylcarbamazine is available only with your doctor's prescription, and only from the manufacturer. Before using diethylcarbamazine In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered: Allergies Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully. Pediatric Although there is no specific information comparing use of diethylcarbamazine in children with use in other age groups, this medicine is not expected to cause different side effects or problems in children than it does in adults. Geriatric Many medicines have not been studied specifically in older people...

• Bancroft's filariasis; • Eosinophilic lung (tropical pulmonary eosinophilia; tropical eosinophilia); • Loiasis; and • River blindness (onchocerciasis). It will not work for other kinds of worm infections (for example, pinworms or tapeworms). Diethylcarbamazine is available only with your doctor's prescription, and only from the manufacturer. • Portions of this document last updated: Feb. 01, 2023 Copyright: © Merative US L.P. 1973, 2023. All rights reserved. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes. • •

What Are Dosages of Diethylcarbamazine? Dosages of Diethylcarbamazine: • Not commercially available in the U.S. • Diethylcarbamazine is available from the Centers for Disease Control (CDC) Drug Service for patients via an investigational new drug (IND) protocol for treatment of certain filarial diseases, including • It is also available for Dosage Considerations – Should be Given as Follows: Filarial Diseases IND protocol from CDC available for treatment of certain filarial diseases, including lymphatic filariasis caused by infection with Wuchereria bancrofti, Brugia malayi, or Brugia timori. • 2-4 g/day orally Adult: • Day 1: 50 mg orally after meals • Day 2: 50 mg orally three times daily • Day 3: 100 mg orally three times daily • Day 4-14: 6 mg/kg/day orally divided three times daily Pediatric: • Day 1: 1 mg/kg orally after meals • Day 2: 1 mg/kg orally three times daily • Day 3: 1-2 mg/kg orally three times daily • Day 4-14: 6 mg/kg/day orally divided three times daily Loa Loa Adult • Day 1: 50 mg orally after meals • Day 2: 50 mg orally three times daily • Day 3: 100 mg orally three times daily • Day 4-21: 9 mg/kg/day orally divided three times daily M. Streptocerca • 6 mg/kg orally once daily for 14 days Tropical Pulmonary Eosinophilia - Adult and Pediatric • IND protocol from CDC available for treatment of tropical pulmonary eosinophilia • Pulmonary eosinophilia, tropical: 6 mg/kg/day divided three times daily for 14 days Larva Migrans, Visceral - Adult and Pediatri...

Latest prescription information about Diethylcarbamazine. Learn how to pronounce the drug's name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, warnings and its storage instructions . Also listed are the Indian trade name(s) of the drug and its price list. Why is Diethylcarbamazine Prescribed? (Indications) Diethylcarbamazine (DEC) is an antihelmintic drug which is prescribed to kill worms and treat the following diseases: a)Bancroft’s filariasis b)Tropical pulmonary eosinophilia c)Loiasis for the treatment, as well as to prevent infection in visitors to endemic areas • Though it is effective in river blindness ( What is the dosage of Diethylcarbamazine? • The dosage is determined based on body weight. Treatment is usually begun with a low dose. a) For the treatment of Bancroft’s filariasis: The recommended adult dose is 2 to 3 mg per kg of body weight three times a day for 12 days. b) For the treatment of eosinophilic lung: The usual adult dose is 6 mg per kg of body weight daily for four to seven days. c) For the treatment of Loiasis: The usual dose is 2 to 3 mg per kg three times daily for 18 days. d) Prevention of loiasis: The usual dose in adults is 300 mg once a week What are the warnings and precautions for Diethylcarbamazine? • DEC should not to be used to treat • Asthma may be worsened in patients who suffer from airway disease a few hours after the first dose but the adverse effect usually decreases after...

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Proper Use Drug information provided by: Diethylcarbamazine should be taken immediately after meals. To help clear up your infection completely, keep taking this medicine for the full time of treatment, even if your symptoms begin to clear up after a few days. In some patients, a second course of this medicine may be required to clear up the infection completely. If you stop taking this medicine too soon, your infection may return. Do not miss any doses. Dosing The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so. The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine. • For oral dosage form (tablets): • For Bancroft's filariasis, loiasis, and river blindness: • Adults—Dose is based on body weight and must be determined by your doctor. The usual dose is 2 to 3 milligrams (mg) per kilogram (kg) (0.9 to 1.3 mg per pound) of body weight three times a day. • Children—Use and dose must be determined by your doctor. • For eosinophilic lung: • Adults—Dose is based on body weight and must be determined by your doctor. The usual dose is 6 mg per...

Key:RCKMWOKWVGPNJF-UHFFFAOYSA-N Y Diethylcarbamazine is a Common side effects include itching, facial swelling, headaches, and feeling tired. Diethylcarbamazine was discovered in 1947 Medical uses [ ] Diethylcarbamazine is [ citation needed] In India and China, diethylcarbamazine has been added to salt to combat lymphatic filariasis. Contraindications [ ] Contraindications are previous history of heart problems, gastrointestinal problems, and allergies. [ medical citation needed] Diethylcarbamazine is contraindicated in patients who may have onchocerciasis, due to the risk of the Mechanism [ ] Diethylcarbamazine is an inhibitor of Society and culture [ ] Brand names [ ] Brand names include Hetrazan, Carbilazine, Caricide, Cypip, Ethodryl, Notézine, Spatonin, Filaribits, Banocide Forte, and Eofil. [ citation needed] Veterinary uses [ ] Diethylcarbamazine is used to prevent [ citation needed] References [ ] • ^ a b c www.cdc.gov. 22 September 2016. . Retrieved 7 December 2016. • ^ a b WHO Model Formulary 2008. World Health Organization. p.91. 9789241547659. • ^ a b c www.drugs.com. . Retrieved 8 December 2016. • Sweet, Richard L.; Gibbs, Ronald S. (2009). Infectious Diseases of the Female Genital Tract. Lippincott Williams & Wilkins. p.382. 9780781778152. • Herbert-Ashton, Marilyn; Clarkson, Nancy Elaine (2005). Quick Look Nursing: Pharmacology. Jones & Bartlett Learning. p.48. 9780763735951. • apps.who.int. 1995. p.152. Archived from . Retrieved 8 December 2016. • Busvine, ...

OC(=O)CC(O)(CC(O)=O)C(O)=O.CCN(CC)C(=O)N1CCN(C)CC1 External Links ChemSpider ChEBI ChEMBL Wikipedia Predicted Properties Property Value Source Water Solubility 106.0 mg/mL logP -1.3 logP 0.092 logS -0.26 pKa (Strongest Basic) 6.9 Physiological Charge 1 Hydrogen Acceptor Count 2 Hydrogen Donor Count 0 Polar Surface Area 26.79 Å 2 Rotatable Bond Count 7 Refractivity 58.28 m 3·mol -1 Polarizability 23.09 Å 3 Number of Rings 1 Bioavailability 1 Rule of Five Yes Ghose Filter Yes Veber's Rule Yes MDDR-like Rule No

Heartworm infections in dogs and cats caused by Dirofilaria immitis are curable and completely preventable. The veterinary practitioner has now a full armamentarium of very efficient chemoprophylactics that are easy and convenient to use and one efficient and safe compound useful for treatment. Yet in spite of all this tools on hand a survey conducted in 2001 among 18,000 veterinary clinics in the USA indicated that the practitioners that responded had detected more than 240,000 dogs and 3,000 cats that needed adulticide treatments just in that year. This alarming information calls attention to potential misuse of the prophylactics available or lack of compliance by the pet owners. CHEMOPROPHYLAXIS Chemoprophylaxis in dogs. All the several formulations available as prophylactic drugs for heartworm infections fall into two basic classes, the macrocyclic lactones or macrolides (avermectins and milbemycins) and diethylcarbamazine. Diethylcarbamazine citrate. The first drug to be employed for prevention of canine heartworm disease was diethylcarbamazine citrate (DEC). At present, the use of daily DEC is fairly limited to the United States and it is rapidly being replaced by the macrocyclic lactones. Macrocyclic lactones or macrolides. Since the discovery of ivermectin and the initial description of activity against developmental stages of D. immitis, a large number of publications have appeared reporting on their attributes and were reviewed by Campbell (1989) and Guerrero et ...