Diphenhydramine hydrochloride

Usual Adult Dose for: • • • • • • • Usual Pediatric Dose for: • • • • • • Additional dosage information: • • • • • Usual Adult Dose for Extrapyramidal Reaction Oral: 25 to 50 mg orally 3 to 4 times a day Parenteral: 10 to 50 mg deep IM or IV as needed, and may increase to 100 mg if required • Maximum dose: 400 mg/day Comment: • IV injection rates should not exceed 25 mg/min. Uses: • Parkinsonism of the elderly who are unable to tolerate more potent agents • Mild cases of parkinsonism in other age groups • Other cases of parkinsonism in combination with centrally acting anticholinergic agents Usual Adult Dose for Insomnia Diphenhydramine Citrate: 76 mg orally once a day at bedtime Diphenhydramine Hydrochloride: 50 mg orally once a day at bedtime Comment: • Patients should contact their healthcare provider if symptoms of insomnia persist for more than 2 weeks while receiving treatment. Uses: • As a nighttime sleep aid • To reduce difficulty falling asleep • Relief of occasional sleeplessness Usual Adult Dose for Motion Sickness Oral: • Prescription formulations: 25 to 50 mg orally 3 to 4 times a day, with the first dose given 30 minutes before exposure to motion and repeated before meals and upon retiring throughout the duration of the journey. Parenteral: 10 to 50 mg deep IM or IV as needed, and may increase to 100 mg if required • Maximum dose: 400 mg/day Comment: • IV injection rates should not exceed 25 mg/min. Use: • Active and prophylactic treatment of motion sickness ...

Use this Before applying, clean the affected area with soap and water. Gently pat dry. Apply to the affected area as directed, usually no more than 3 to 4 times a day. Wash hands immediately after use, unless the area being treated includes the hands. Do not use on large areas of the body or use more often than directed. Your condition will not improve any faster, and your risk of side effects will increase. Avoid getting the product in your Stop using this product and tell your doctor if your condition worsens, if symptoms do not improve within 7 days or last after 7 days of treatment, or if symptoms clear up and return in a few days. If you think you may have a serious medical problem, get medical help right away. Mild stinging may occur. If this effect lasts or gets worse, stop using this product and tell your doctor or If your doctor has directed you to use this Though very unlikely, it is possible this medication could be absorbed into your A very serious This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist. In the US - Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch. In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

• Discover information about different types of cancer • • • • • • • • • • • • • • • • • • • • • • • • • • • • • Learn about cancer, diagnosis, treatment, coping & survivorship • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • Find resources & tools for oncology healthcare professionals • • • • • • • • • • • • • • Diphenhydramine hydrochloride is an antihistamine. Antihistamines are used for many reasons, such as for treating and preventing allergic reactions (including anaphylaxis), motion sickness, and some movement disorders. Diphenhydramine hydrochloride works by blocking histamine in the body. Histamine occurs naturally in the body and is part of our immune system. Histamine is released when foreign allergens (like pollen, cat dander, certain medications) enter our body. Histamine tries to rid our body of the allergen, through things like sneezing, itching, or tearing up. This medication sheet will focus on diphenhydramine hydrochloride used during cancer treatment. How this Medication Comes This medication comes as tablets, capsules, an oral solution (liquid), intramuscular (IM, into a muscle), and intravenous (IV, into a vein) formulations. It can also come as a spray or mist, and as a topical ointment or cream. This medication sheet will focus on the oral, IM, and IV formulations of diphenhydramine hydrochloride. How to Take Diphenhydramine Hydrochloride (Benadryl®) How you take diphenhydramine hydrochloride depends on why ...

diphenhydrAMINE (Monograph) Brand names: Hydramine, Nighttime Sleep Aid, Nytol, Sleepinal, Sominex, Twilite, Unisom Drug class: First Generation Antihistamines - Antiparkinsonian Agents ATC class: D04AA32 VA class: AH200 CAS number: 88637-37-0 • • • • • • • Introduction First generation antihistamine; an ethanolamine-derivative. Related/similar drugs Uses for diphenhydrAMINE Acute Allergic Reactions Amelioration of allergic reactions to blood or plasma. Adjunct to epinephrine and other standard measures for management of anaphylaxis after acute symptoms have been controlled. Used IV or IM for management of other uncomplicated allergic conditions of the immediate type when oral therapy is impossible or contraindicated. Allergic Rhinitis Self-medication for temporary relief of rhinorrhea, sneezing, lacrimation, itching eyes, oronasopharyngeal irritation or itching, or cough associated with allergic rhinitis (e.g., hay fever) or other upper respiratory allergies. Used in fixed combination with other agents (e.g., acetaminophen, phenylephrine) for relief of rhinorrhea, sneezing, lacrimation, itching eyes, oronasopharyngeal itching, and/or other symptoms (e.g., headache, nasal/sinus congestion) associated with seasonal or perennial allergic rhinitis or other upper respiratory allergies. Use fixed-combination preparations only when symptoms amenable to each ingredient are present concurrently. Common Cold Self-medication for temporary relief of symptoms associated with the commo...

What Is Benadryl? Benadryl (diphenhydramine) is an antihistamine used to treat allergies, hives, insomnia, What Are Side Effects of Benadryl? Benadryl may cause serious side effects including: • pounding heartbeats or fluttering in your chest, • painful or difficult urination, • little or no urination, • confusion, • lightheadedness, • tightness in your neck or jaw, and • uncontrollable movements of your tongue Get medical help right away, if you have any of the symptoms listed above. Common side effects of Benadryl include: • drowsiness, • fatigue, • tiredness, • sleepiness, • dizziness, • disturbed coordination, • constipation, • • difficulty urinating or an enlarged • upset stomach, • blurred vision, • double vision, • • loss of appetite, • headache, or • nausea. Seek medical care or call 911 at once if you have the following serious side effects: • Serious eye symptoms such as sudden vision loss, blurred vision, tunnel vision, eye pain or swelling, or seeing halos around lights; • Serious heart symptoms such as fast, irregular, or pounding heartbeats; fluttering in your chest; shortness of breath; and sudden dizziness, lightheadedness, or passing out; • Severe headache, confusion, slurred speech, arm or leg weakness, trouble walking, loss of coordination, feeling unsteady, very stiff muscles, high fever, profuse sweating, or tremors. This document does not contain all possible side effects and others may occur. Check with your physician for additional information about...

Diphenhydramine: 7 things you should know Medically reviewed by • • • • • • • 1. How it works • Diphenhydramine is an antihistamine that may be used for the treatment of allergies, motion sickness, to help induce sleep, and to relieve symptoms of Parkinson's Disease. • Diphenhydramine treats allergic-type reactions by blocking histamine-1 (H1) receptors. This prevents histamine from having an effect on the airways, blood vessels, and the gastrointestinal tract, reversing symptoms such as bronchoconstriction (narrowing of the airways), rash and itch, and stomach cramps. Diphenhydramine also blocks acetylcholine receptors, sodium channels, and inhibits the reuptake of serotonin, among other effects. These latter effects are responsible for its sedative effects and side effects such as a dry mouth. • Diphenhydramine belongs to the class of medicines known as first-generation antihistamines. Diphenhydramine is an antihistamine of the ethanolamine class. 2. Upsides • Used to treat the symptoms of allergic-type reactions such as sneezing, itching, watery eyes, and runny nose. • May be used for the treatment of allergies, insect bites, hay fever, allergic conjunctivitis, urticaria (hives), and in addition to epinephrine for anaphylactic reactions. • May be used to relieve the symptoms of nausea and vomiting associated with motion sickness. • Can be used to help people relax or fall asleep. • May also be used for elderly people with Parkinson's disease who are unable to tolerate m...

Dosage instructions: Two tablets to be taken 20 minutes before going to bed, or as directed by a physician. Do not exceed the stated dose or frequency of dosing. Children: Do not use in children under 16 years. This medicinal product should not be used continuously for longer than 2 weeks without consulting a doctor. Method of administration For oral administration. 4.3 Contraindications Diphenhydramine is contraindicated for patients known to be hypersensitive to the drug or to any of the excipients listed in section 6.1. Contraindicated for use in patients with the following conditions: stenosing peptic ulcer, pyloroduodenal obstruction. 4.4 Special warnings and precautions for use Diphenhydramine should be used with caution in patients with myasthenia gravis, epilepsy or seizure disorders, prostatic hypertrophy, urinary retention, narrow-angle glaucoma, asthma, bronchitis and chronic obstructive pulmonary disease (COPD), moderate to severe hepatic impairment and moderate to severe renal impairment. Tolerance may develop with continuous use. Seek medical advice if sleeplessness persists, as insomnia may be a symptom of a serious underlying medical illness. This medicinal product should not be used continuously for longer than 2 weeks without consulting a doctor. May increase the effects of alcohol, therefore alcohol should be avoided. Avoid use of other antihistamine-containing preparations, including topical antihistamines and cough and cold medicines. Use with caution ...

Diphenhydramine Hydrochloride In the case of diphenhydramine hydrochloride it has been concluded [145] that the drug show aggregation beyond 0.05 M concentration. From: Studies in Interface Science, 2005 Related terms: • Analytes • Electrochemiluminescence • Nanotube • Sodium Deoxycholate • Ionic Liquid • Micelle • Critical Micelle Concentration • Aqueous Solution S.M. Miller, K.L. Cumpston, in Encyclopedia of Toxicology (Third Edition), 2014 Environmental Fates and Behavior Physicochemical Properties Diphenhydramine hydrochloride has the appearance of a white crystalline powder. It is odorless and has a bitter, numbing taste. It is soluble in water and aqueous solutions are acidic. It has a melting point of 166–169 °C and the boiling point ranges from 150 to 165 °C at 2E 0 mmHg. Diphenhydramine has a water solubility of 3060 mg l −1 at 37 °C. Density is 1.013–1.012. Log P is 3.27. The p K a is 8.98 and the Log S is −3.5. Refractivity is 79.93 and polarizability is 29. Diphenhydramine is fairly stable in the environment although it does undergo photodegradation. Conjugates of diphenhydramine such as diphenhydramine- N-glucuronide may be converted back to the parent compound, diphenhydramine, through enzymatic cleavage during sewage treatment process. Diphenhydramine is removed poorly through wastewater treatment processes and is found in significant concentrations in aquatic organisms downstream from such plants. Diphenhydramine has significant risk for bioaccumulation, pa...