Drotaverine hydrochloride tablets uses

Drotaverine hydrochloride Drotaverine hydrochloride has antispasmodic effect mediated via inhibition of phosphodiesterase-IV, specific for smooth muscle. It has a rapid and direct action on the smooth muscle. It acts to correct cyclic AMP and Ca imbalance at the spastic site, thereby relieving smooth muscle spasm and pain. Drotaverine hydrochloride is an e spasmolytic agent with a relaxing effect on smooth muscles. It works to relieve visceral spasms and improve cervical dilation. In vitro, drotaverine mediated cytostatic effects on several human tumor cell lines and nonmalignant mouse fibroblasts. Drotaverine hydrochloride may have minor allosteric calcium channel blocking properties: in vitro, drotaverine behaves like voltage-dependent L-type calcium channel blockers.[A231624] Uses Spastic conditions of the gastrointestinal tract, irritable bowel syndrome- • Biliary colics and spastic conditions of the biliary tract: Cholecystolithiasis, cholecystitis, cholangitis. • Renal colics and spastic conditions of the urogenital tract: Nephrolithiasis, ureterolithiasis, pyelitis, cystitis. • Spastic conditions of the uterus: Dysmenorrhea, imminent abortion, uterine tetanus. Drotaverine hydrochloride is also used to associated treatment for these conditions: Abdominal Pain caused by Gall Stones, Abdominal Pain caused by Kidney Stones, Muscle Spasms, Spastic Pain, Spastic Pain caused by Cystitis, Spastic Pain caused by Funicular Nephritis, Spastic Pain caused by Gallbladder disorde...

Identification Summary Drotaverine is a phosphodiesterase-4 inhibitor used to alleviate gastrointestinal and genitourinary smooth muscle spasms. Generic Name Drotaverine DrugBank Accession Number DB06751 Background Drotaverine is an antispasmodic drug that works by inhibiting phosphodiesterase-4 (PDE4). Drotaverine is not approved by the FDA, European Medicines Agency, or Health Canada. It is approved for use in Thailand as oral tablets or intramuscular injections. Type Small Molecule Groups Approved, Investigational Structure Learn more Pharmacodynamics Drotaverine is an e spasmolytic agent with a relaxing effect on smooth muscles. It works to relieve visceral spasms and improve cervical dilation. In vitro, drotaverine mediated cytostatic effects on several human tumor cell lines and nonmalignant mouse fibroblasts. in vitro, drotaverine behaves like voltage-dependent L-type calcium channel blockers. Mechanism of action Drotaverine is a selective inhibitor of phosphodiesterase 4 (PDE4), which is an enzyme responsible for the degradation of cyclic adenosine monophosphate (cAMP). Inhibition of PDE4 leads to elevated levels of cAMP, leading to smooth muscle relaxation. Recent research showed that low levels of cAMP have been associated with brain tumorigenesis, leading to the investigation of PDE4 inhibitors as potential anticancer agents. Target Actions Organism A inhibitor Humans Absorption Drotaverine is not completely absorbed following oral administration and its bioavai...

Scope of application: gastric, intestinal spasms caused by spasms of smooth muscles, which can occur with spastic constipation, gallstone and urolithiasis, angina pectoris, headaches of tension spasm of the peripheral vessels, diseases of the biliary tract (papillitis, cholecystolithiasis, holocholecystitis ), gastrointestinal tract (stomach ulcer, duodenal ulcer, spastic colitis, gastritis, enteritis, colitis). Description No-shpa composition The main active ingredient is drotaverine hydrochloride, it also has additional substances. Release form It is produced in tablet form. Pharmacological properties By lowering the tone of the smooth muscles of the abdominal organs, No-shpa is able to reduce their motor activity, while slightly expanding the blood vessels. More effective than papaverine. Does not affect the autonomic nervous and central nervous systems. Indications Scope of application: gastric, intestinal spasms caused by spasms of smooth muscles, which can occur with spastic constipation, gallstone and urolithiasis, angina pectoris, headaches of tension spasm of the peripheral vessels, diseases of the biliary tract (papillitis, cholecystolithiasis, holocholecystitis ), gastrointestinal tract (stomach ulcer, duodenal ulcer, spastic colitis, gastritis, enteritis, colitis). It is also prescribed for diseases of the urinary system, in which smooth muscles spasm – nephrolithiasis, urethrolithiasis, cystitis, pyelitis, tenesmus of the bladder, pain in gynecology, including...

DROTIN A 80 MG/100 MG TABLET is a combination medicine used in the treatment of abdominal pain. It works effectively to reduce abdominal pain, bloating, discomfort and cramps by relaxing the muscles of the stomach and gut. It also blocks certain chemical messengers that cause pain and discomfort. DROTIN A 80 MG/100 MG TABLET is taken with food in a dose and duration as advised by the doctor. The dose you are given will depend on your condition and how you respond to the medicine. You should keep taking this medicine for as long as your doctor recommends. If you stop treatment too early your symptoms may come back and your condition may worsen. Let your healthcare team know about all other medications you are taking as some may affect, or be affected by this medicine. The most common side effects are diarrhea, nausea, vomiting, stomach pain, loss of appetite, dryness in the mouth, feeling thirsty, and heartburn. Most of these are temporary and usually resolve with time. Contact your doctor straight away if you are at all concerned about any of these side effects. It may also cause dizziness, so do not drive or do anything that requires mental focus until you know how this medicine affects you. Avoid drinking alcohol while taking this medicine as it can worsen your dizziness. Before taking this medicine, you should tell your doctor if you are pregnant, planning pregnancy or breastfeeding. You should also tell your doctor if you have any kidney or liver diseases so that your ...