Endocrine disrupting chemicals

Various chemicals are known to impact biological systems disrupting normal homeostasis, especially the endocrine system, called endocrine disrupting chemicals. Endocrine disrupting chemicals are universal in the environment, and a low concentration (µg/L to ng/L) severely impacts human health and wildlife due to transgenerational and multigenerational effects. The present review analyzed original research articles (109), review articles (76), short communication (20), article report (1), monograph (1), and scientific reports (2) via PubChem, science direct, National Center for Biotechnology Information, web of science on the source and fate of endocrine disrupting chemicals in the environment which are a prime concern to public health. A thorough investigation of the fate of these contaminants in environmental matrices such as air, water, soil, and biota is prioritized to form a clear link between the exposure and its effect on humans and biota. Environmental guidelines for these chemicals in environmental matrices and their treatment methods are also discussed in the review. Graphical abstract • Abbasi Y, Mannaerts CM (2020) Exploring the environmental exposure to methoxychlor, α -HCH and endosulfan – sulfate residues in lake Naivasha (Kenya) using a multimedia fate modeling approach. Int J Environ Res Public Health 17:1–18. • Abderrazik NB, Azman A, R’kiek C, Song W, O'Shea KE (2005) Iron (II)-catalyzed enhancement of ultrasonic-induced degradation of diethylstilbestrol ...

Endocrine Disrupting Chemicals (EDCs) are a global problem for environmental and human health. They are defined as “an exogenous chemical, or mixture of chemicals, that can interfere with any aspect of hormone action”. It is estimated that there are about 1000 chemicals with endocrine-acting properties. EDCs comprise pesticides, fungicides, industrial chemicals, plasticizers, nonylphenols, metals, pharmaceutical agents and phytoestrogens. Human exposure to EDCs mainly occurs by ingestion and to some extent by inhalation and dermal uptake. Most EDCs are lipophilic and bioaccumulate in the adipose tissue, thus they have a very long half-life in the body. It is difficult to assess the full impact of human exposure to EDCs because adverse effects develop latently and manifest at later ages, and in some people do not present. Timing of exposure is of importance. Developing fetus and neonates are the most vulnerable to endocrine disruption. EDCs may interfere with synthesis, action and metabolism of sex steroid hormones that in turn cause developmental and fertility problems, infertility and hormone-sensitive cancers in women and men. Some EDCs exert obesogenic effects that result in disturbance in energy homeostasis. Interference with hypothalamo-pituitary-thyroid and adrenal axes has also been reported. In this review, potential EDCs, their effects and mechanisms of action, epidemiological studies to analyze their effects on human health, bio-detection and chemical identificat...

Endocrine disruptors or endocrine-disrupting chemicals (EDCs) are substances in the environment that can interfere with the actions of hormones in our bodies. Through a number of mechanisms, endocrine disruptors have been linked to several cancers, including those of the thyroid, breast, and prostate. For those who are living with cancer, there is also some concern that exposures could enhance the progression or While learning about a potential connection between substances we encounter each day and medical conditions (ranging from cancer to decreased IQ in children) can be disconcerting, knowledge can truly be power in this setting. Fortunately, having an awareness of where these chemicals hide, and making simple changes to your lifestyle, may not only reduce your health risks due to exposure, but could be aesthetically pleasing and benefit your budget as well. When evaluating chemicals in the environment with regard to health, the conventional approach is to look at the effect of high doses over a short period of time. What we've learned with endocrine-disrupting chemicals, however, is that low dose exposure over an extended period of time (and to the combination of a number of these chemicals) is of greater concern—a concern that many researchers believe has been largely underestimated. What Chemicals Are Considered Endocrine Disruptors? The following list contains some of the chemicals classified as endocrine disruptors, meaning that they can interfere with the actions...

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Why We Care Endocrine-disrupting chemicals (EDCs) are an exogenous chemical, or mixture of chemicals, that can interfere with any aspect of hormone action. EDCs such as bisphenols, phthalates, and Since 2013, the Endocrine Society has made improving regulation of EDCs a top priority and has been the leading voice of science in global policy. The Endocrine Society supports effective translation of scientific knowledge on EDCs and their health effects to regulatory policies that protect consumers and improve regulatory testing guidelines. More information on our policy recommendations can be found on our See the Endocrine Society’s For more information about EDC European Union action, see our A Guide for Public Interest Organizations and Policymakers The Endocrine Society and IPEN developed • • • • • • Policy Communications View all of our position statements, scientific statements, press releases, advocacy letters to lawmakers, and more in the listing below. You can also use the Content Filter to view specific types of content. Position Statements Regarding Endocrine-Disrupting Chemicals • Statement on • Statement on

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