European journal of molecular and clinical medicine

European Journal of Molecular & Clinical Medicine (EJMCM) is an open access Scopus Indexed online journal (Formerly handled by Elsevier) publishing high quality manuscripts covering all aspects of molecular and clinical medicine. Submitted manuscripts are peer reviewed and selection is based on scientific excellence, distinctive contribution to knowledge and importance to the field. Distinctions: The most widely read, cited, and known Molecular & Clinical Medicine journal and website is well browsed with all the articles published. More than 30,000 readers per month

EJNMMI Research publishes new basic, translational and clinical research in the field of nuclear medicine and molecular imaging. Regular features include original research articles, rapid communication of preliminary data on innovative research, interesting case reports, editorials, and letters to the editor. Educational articles on basic sciences, fundamental aspects and controversy related to pre-clinical and clinical research or ethical aspects of research are also welcome. Timely reviews provide updates on current applications, issues in imaging research and translational aspects of nuclear medicine and molecular imaging technologies. The main emphasis is placed on the development of targeted imaging with radiopharmaceuticals within the broader context of molecular probes to enhance understanding and characterisation of the complex biological processes underlying disease and to develop, test and guide new treatment modalities, including radionuclide therapy. Content type: Original research 15 June 2023 • 64Cu/ 177Lu 1C1m-Fc anti TEM-1: mice-to-human dosimetry extrapolations for future theranostic applications Authors: Silvano Gnesin, Nicolas Chouin, Michel Cherel, Steven Mark Dunn, Niklaus Schaefer, Alain Faivre-Chauvet, John O. Prior and Judith Anna Delage Nuclear medicine is a vibrant and rapidly developing field in biomedical research. Within the family of EJNMMI journals, EJNMMI research focuses on translational research, aiming to be the bridge between basic and ...

Title proper: European journal of molecular and clinical medicine. Abbreviated key-title: Eur. j. mol. clin. med. Other variant title: EJMCM Other variant title: European journal of molecular & clinical medicine Original alphabet of title: Basic roman Subject: Dewey : 610 Subject: Medical sciences Corporate contributor: European Society for Translational Medicine, Earliest publisher: London: Ubiquity Press, 2018- Latest publisher: Barking London: [publisher not identified] Dates of publication: 2018- 9999 Description: Volume 5 (2018)- Frequency: Annual Type of resource: Periodical Language: English Country: United Kingdom Note: Latest issue consulted: volume 8, issue 4 (summer 2021) (viewed October 29, 2021). Medium: Online Indexed by: Indexed by: THE KEEPERS Indexed by: SCOPUS Indexed by: CROSSREF Indexed by: Indexed by: Indexed by: ROAD

Aims Cardiac troponin T (cTnT) and troponin I (cTnI) are expressed as an obligate 1:1 complex in the myocardium. However, blood levels of cTnI often rise much higher than that of cTnT in myocardial infarction (MI), whereas cTnT is often higher in patients with stable conditions such as atrial fibrillation. Here we examine high-sensitive (hs) cTnI and hs-cTnT after different durations of experimental cardiac ischaemia. Methods and results hs-cTnI, hs-cTnT, and the hs-cTnT/hs-cTnI ratio were measured in plasma samples from rats before and at 30 and 120 min after 5, 10, 15, and 30 min of myocardial ischaemia. The animals were killed after 120 min of reperfusion, and the infarct volume and volume at risk were measured. hs-cTnI, hs-cTnT, and the hs-cTnT/hs-cTnI ratio were also measured in plasma samples collected from patients with ST-elevation myocardial infarction (STEMI). hs-cTnT and hs-cTnI increased over 10-fold in all rats subjected to ischaemia. The increase of hs-cTnI and hs-cTnT after 30 min was similar, resulting in a hs-cTnI/hs-cTnT ratio around 1. The hs-cTnI/hs-cTnT ratio was also around 1 in blood samples collected at 120 min in rats subjected to 5 or 10 min of ischaemia where no localized necrosis was observed. In contrast, the hs-cTnI/hs-cTnT ratio at 2 h was 3.6–5.5 after longer ischaemia that induced cardiac necrosis. The large hs-cTnI/hs-cTnT ratio was confirmed in patients with anterior STEMI. Conclusion Both hs-cTnI and hs-cTnT increased similarly after bri...

• Authors: Christiane Matuschek, Friedrich Moll, Heiner Fangerau, Johannes C. Fischer, Kurt Zänker, Martijn van Griensven, Marion Schneider, Detlef Kindgen-Milles, Wolfram Trudo Knoefel, Artur Lichtenberg, Balint Tamaskovics, Freddy Joel Djiepmo-Njanang, Wilfried Budach, Stefanie Corradini, Dieter Häussinger, Torsten Feldt… Continuous renal replacement therapy (CRRT) remains a crucial treatment for critically ill patients with acute kidney injury (AKI), although the timing of its initiation is still a matter of contention. Furosemide stress testing (FST) may be a practical and beneficial prediction instrument. This research was meant to examine if FST can be used to identify high-risk patients for CRRT. European Journal of Medical Research publishes translational, preclinical and clinical research of international interest across all medical disciplines, enabling clinicians and other researchers to learn about developments and innovations within these disciplines and across the boundaries between disciplines. The journal also has a special focus on internal medicine, surgery, neurology, infectious diseases and intensive care medicine. European Journal of Medical Research publishes high quality research and reviews and aims to ensure that the results of all well-conducted research are published, regardless of their outcome. Prof Edwin Bölke studied medicine at the University of Tübingen from 1983 to 1990, and finished his medical thesis in 1993. He completed the America...