Fexofenadine hydrochloride

Usual Adult Dose for: • • Usual Pediatric Dose for: • • Additional dosage information: • • • • • Usual Adult Dose for Allergic Rhinitis 180 mg orally once a day OR 60 mg orally 2 times a day • Maximum dose: 180 mg/day Comment: • Tablets should be taken with water. Uses: • Relief of symptoms associated with seasonal allergic rhinitis (e.g., runny nose, sneezing, itchy, watery eyes, itching of the nose/throat) • Treatment of uncomplicated skin manifestations of chronic idiopathic urticaria Usual Adult Dose for Urticaria 180 mg orally once a day OR 60 mg orally 2 times a day • Maximum dose: 180 mg/day Comment: • Tablets should be taken with water. Uses: • Relief of symptoms associated with seasonal allergic rhinitis (e.g., runny nose, sneezing, itchy, watery eyes, itching of the nose/throat) • Treatment of uncomplicated skin manifestations of chronic idiopathic urticaria Usual Pediatric Dose for Allergic Rhinitis 6 months to 2 years: 15 mg orally 2 times a day 2 years to 11 years: 30 mg orally 2 times a day 12 years and older: 180 mg orally once a day OR 60 mg orally 2 times a day Comments: • The oral suspension may be used by patients 6 months and older. • Tablets and oral dissolving tablets may be used by patients 6 to 11 years of age. • Gel-coated tablet formulations should be limited to patients 12 years and older. Uses: • Relief of symptoms associated with seasonal allergic rhinitis (e.g., runny nose, sneezing, itchy, watery eyes, itching of the nose/throat) • Treatment ...

Antihistamines work by preventing the effects of a substance called histamine, which is produced by the body. Histamine can cause itching, sneezing, runny nose, and watery eyes. Also, in some people histamine can close up the bronchial tubes (air passages of the lungs) and make breathing difficult. Histamine can also cause some people to have hives, with severe itching of the skin . This medicine is available only with your doctor's prescription . Do not give any over-the-counter (OTC) cough and cold medicine to a baby or child under 4 years of age. Using these medicines in very young children might cause serious or possibly life-threatening side effects . This product is available in the following dosage forms: • Tablet • Suspension • Tablet, Disintegrating • Portions of this document last updated: May 01, 2023 Copyright: © Merative US L.P. 1973, 2023. All rights reserved. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes. • •

Fexofenadine Generic name: fexofenadine [ FEX-oh-FEN-a-deen] Brand names: Allegra 12 Hour Allergy, Allegra 24 Hour Allergy, Allergy Relief (Fexofenadine HCl), Children's Allegra Allergy, Children's Allegra ODT Dosage forms: oral suspension, oral tablet, oral disintegrating tablet Drug class: Medically reviewed by • • • • • • • What is fexofenadine? Fexofenadine is an antihistamine that may be used to treat Fexofenadine is also used to treat skin itching and Fexofenadine works selectively on histamine-1 receptors that are located in our body, but not in our central nervous system - these are called peripheral histamine receptors. Because it acts on these receptors, fexofenadine is much less likely to cause drowsiness compared with some older antihistamines. Histamine is a chemical that is released by mast cells in response to an allergen, and it is responsible for many allergy symptoms, such as watery eyes, a runny nose, sneezing, and itching. Fexofenadine binds to histamine receptors and prevents histamine from having an effect on those receptors, which reduces allergy symptoms. There are many brands and forms of fexofenadine available. Fexofenadine was FDA approved in 1996. Related/similar drugs Warnings Do not take fexofenadine with fruit juice (such as apple, orange, or grapefruit). Before taking this medicine You should not use fexofenadine if you are allergic to it. Ask a doctor or pharmacist if fexofenadine is safe to use if you have: • kidney disease. Ask a doctor b...

You should NOT take antacids that contain aluminum or magnesium hydroxide within 15 minutes of taking this medicine. If you are uncertain about this, ask your doctor or pharmacist . For patients using the oral disintegrating tablet form of this medicine: • Make sure your hands are dry. • Do not push the tablet through the foil backing of the package. Instead, gently peel back the foil backing and remove the tablet. • Immediately place the tablet on top of the tongue. Do not chew or break the tablet. • The tablet will dissolve in seconds, and you may swallow it with your saliva. You may drink a glass of water after the tablet has dissolved. • Always take this tablet on an empty stomach . Shake the oral liquid well before using it. Measure the liquid with a marked measuring spoon, oral syringe, or medicine cup . Dosing The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so. The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine. • For symptoms of hay fever: • For oral dosage form (capsules, tablets): • Adults and children 12 years of age an...

Fexofenadine: 7 things you should know Medically reviewed by • • • • • • • 1. How it works • Fexofenadine is an antihistamine that may be used to treat allergy symptoms. • Fexofenadine works selectively on peripheral histamine-1 (H-1) receptors (these are histamine receptors that are located outside of the brain and spinal cord, such as in the gastrointestinal tract, the blood vessels, and the respiratory tract). Because it acts on peripheral histamine receptors, fexofenadine is much less likely to cause drowsiness compared with some older antihistamines. • Histamine is a chemical that is released by mast cells in response to an allergen, and it is responsible for many of the symptoms of an allergic reaction, such as swelling of the mucous membranes, sneezing, and itching. Fexofenadine binds to histamine receptors and prevents histamine from having an effect on those receptors, which reduces the symptoms of an allergic reaction. • Fexofenadine belongs to the group of drugs known as antihistamines. Fexofenadine may also be called an H1-antihistamine, a second-generation antihistamine, or a nonsedating antihistamine. 2. Upsides • May be used for the short-term relief of runny nose, sneezing, itching of the nose or throat, or itchy watery eyes due to hay fever or other respiratory allergens. • Used to treat allergic-type reactions due to hay fever (seasonal allergic rhinitis) or other upper respiratory allergies. • Effective at controlling symptoms such as sneezing, itching, ...

If you are taking the over-the-counter product to self-treat, read all directions on the product package before taking this If you are using the liquid form of this medication, shake the bottle well before each dose and measure the dose carefully using a special measuring device/spoon. Do not use a household spoon because you may not get the correct dose. Take the tablet/capsule or liquid form of this medication with or without food. If you are using the rapidly-dissolving tablet, take it on an empty If you need a liquid to take this medication (such as when taking the tablets/capsules), then take this medication with water. Do not take with fruit juices (such as apple, grapefruit, or orange) since they may decrease the absorption of this drug. The dosage is based on your age, medical condition, and response to treatment. Do not increase your dose or take this medication more often than directed. Do not take antacids containing aluminum and Tell your doctor if your condition does not improve or if it worsens. If your doctor has prescribed this A very serious This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist. In the US - In the US - Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch. In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-...

Fexofenadine Tablets Generic name: Fexofenadine Tablets [ feks-oh-FEN-a-deen] Brand name: Drug class: • • • • • • • Uses of Fexofenadine Tablets: • It is used to ease allergy signs. • It is used to treat What do I need to tell my doctor BEFORE I take Fexofenadine Tablets? • If you have an allergy to • If you are allergic to this medicine (fexofenadine tablets); any part of this medicine (fexofenadine tablets); or any other drugs, foods, or substances. Tell your doctor about the allergy and what signs you had. This medicine may interact with other drugs or health problems. Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, What are some things I need to know or do while I take Fexofenadine Tablets? • Tell all of your health care providers that you take this medicine (fexofenadine tablets). This includes your doctors, nurses, pharmacists, and dentists. • This medicine may affect certain lab tests. Tell all of your health care providers and lab workers that you take this medicine (fexofenadine tablets). • Talk with your doctor before you drink alcohol or use other drugs and natural products that slow your actions. • If you drink • If you are 65 or older, use this medicine (fexofenadine tablets) with care. You could have more side effects. • Tell your doctor if you are pregnant, plan on getting pregnant, or are breast-feeding. You will need to talk about the benefits and risks to you and the baby. Related/similar drugs How is this m...

Key:RWTNPBWLLIMQHL-UHFFFAOYSA-N Y N Y Fexofenadine, sold under the brand name Allegra among others, Therapeutically, fexofenadine is a 1 blocker. It is classified as a second-generation antihistamine because it is less able to pass the It was patented in 1979 and came into medical use in 1996. million prescriptions. Medical uses [ ] Fexofenadine is used for relief from physical symptoms associated with seasonal Efficacy [ ] For the treatment of Fexofenadine at doses above 120mg a day does not appear to provide additional efficacy in the treatment of allergic rhinitis. Side effects [ ] The most common Overdose [ ] The safety profile of fexofenadine is quite favorable, as no Pharmacology [ ] Pharmacodynamics [ ] Fexofenadine is a 1 receptor antagonist. Blockage prevents the activation of the H 1 receptors by Fexofenadine also exhibits no Pharmacokinetics [ ] • • • • Interactions [ ] Taking [ citation needed] Fexofenadine is not to be taken with apple, orange, or grapefruit juice because they could decrease absorption of the drug. Therefore, it should be taken with water. increase under increasingly alkaline pH), but rather due to the formation of metal complexes with charged/polar moieties on fexofenadine. As suggested by Shehnaza et al (2014), various sites of the molecule are thought to be responsible for this interaction, including the piperidine nitrogen, the carboxylic acid (-COOH) group, and both hydroxyl (-OH) groups. History [ ] The older antihistaminic agent [ citat...