Frank starling law

Introduction The Frank-Starling relationship is based on the link between the initial length of myocardial fibers and the force generated by contraction. There is a predictable relationship between the length between sarcomeres and the tension of the muscle fibers. There is an optimal length between sarcomeres at which the tension in the muscle fiber is greatest, resulting in the greatest force of contraction. If sarcomeres are closer together or further apart compared to this optimal length, there will be a decrease in contraction tension and strength. Thegreater the ventricular diastolic volume, the more the myocardial fibers are stretched during diastole. Within a normal physiologic range, the more the myocardial fibers are stretched, the greater the tension inthe muscle fibers and the greater force of contraction of the ventricle when stimulated. The Frank-Starling relationship is the observation that ventricular output increases as preload (end-diastolic pressure) increases. Mechanism The left ventricular performance (Frank-Starling) curves relate preload, measured as left ventricular end-diastolic volume (EDV) or pressure, to cardiac performance, measured as ventricular stroke volume or cardiac output. On the curve of a normally functioning heart, cardiac performance increases continuously as preload increases. During states of increased left ventricular contractility, for example, due to norepinephrine infusion, there is a greater cardiac performance for a given pre...

Frank–Starling law of the heart, the y-axis often describes the The Frank–Starling law of the Starling's law and the Frank–Starling mechanism) represents the relationship between Physiology [ ] The Frank-Starling mechanism occurs as the result of the length-tension relationship observed in striated muscle, including for example The stretching sarcomeres augments cardiac 2+ increases and there is an increased release of Ca 2+ from the 2+ from the internal store, the 2+ spark rate upon axial stretch of single cardiac myocytes. Due to the intrinsic property of Clinical examples [ ] Premature ventricular contraction [ ] Diastolic dysfunction – heart failure [ ] History [ ] The Frank–Starling law is named after the two physiologists, "legge del cuore" . [ excessive citations] Otto Frank's contributions are derived from his 1895 experiments on frog hearts. In order to relate the work of the heart to skeletal muscle mechanics, Frank observed changes in diastolic pressure with varying volumes of the frog ventricle. His data was analyzed on a pressure-volume diagram, which resulted in his description of peak isovolumic pressure and its effects on ventricular volume. Starling experimented on intact mammalian hearts, such as from dogs, to understand why variations in arterial pressure, heart rate, and temperature do not affect the relatively constant cardiac output. See also [ ] • References [ ] • ^ a b c d e f g h i Widmaier, E. P., Hershel, R., & Strang, K. T. (2016). Vander's Huma...

: a statement in physiology: the strength of the heart's systolic contraction is directly proportional to its diastolic expansion with the result that under normal physiological conditions the heart pumps out of the right atrium all the blood returned to it without letting any back up in the veins called also Frank-Starling law, Frank-Starling law of the heart, Starling's law