Gonadotropin releasing hormone

The female reproductive system is a wonderfully complex system involving continuous communication between the brain centers and the ovary. Hormones secreted by the hypothalamus, the pituitary and the ovary are the messengers that regulate the monthly cycle. The Hypothalamus and the Pituitary The hypothalamus is located centrally in the brain and communicates by way of an exchange of blood with the pituitary gland. Several neuroendocrine agents, or hormones, are produced by the hypothalamus. The most important hormone for reproduction is called gonadotropin releasing hormone, better known as GnRH. It is released in a rhythmic fashion every 60 to 120 minutes. GnRH stimulates the pituitary gland to produce follicle stimulating hormone (FSH), the hormone responsible for starting follicle (egg) development and causing the level of estrogen, the primary female hormone, to rise. Leutinizing hormone (LH), the other reproductive pituitary hormone, aids in egg maturation and provides the hormonal trigger to cause ovulation and the release of eggs from the ovary. The Ovary The main function of the ovaries is the production of eggs and hormones. At birth, the ovaries contain several million immature eggs. No new eggs will be developed. These eggs are constantly undergoing a process of development and loss. Most will die without reaching maturity. This process of egg loss occurs at all times, including before birth, before puberty and while on birth control pills. The ovary undergoes a...

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript. DS is the most common genetic cause of intellectual and developmental disabilities. DS is typically caused by an extra copy of human chromosome 21 (HSA21). Lifelong overexpression of the HSA21-linked genes produces global alterations in gene expression patterns, resulting in a wide array of pathological and clinical manifestations. A notable feature of DS is the striking propensity for those affected to develop Alzheimer’s Disease (AD) and dementia. The therapeutic effects of GnRH in DS. a Developmental timeline showing the onset and progression of pathology in Ts65Dn mice, as reported in the highlighted paper. b Summary of the intervention strategies to rescue GnRH and their therapeutic effects in Ts65Dn mice. c Diagram showing how GnRH could boost cognition in humans. GnRH therapy may restore network dysfunction in the brain by strengthening the connectivity between cortical areas (Cx) that are hypoconnected in DS, and weakening abnormally hyperconnected subcortical areas, such as the hippocampus (Hpx) and amygdala (Amy). GnRH may also act to improve information processing at the cellular level by modulating neuronal excitability. Image create...

Gonadotropin releasing hormone (GnRH) is a hormone produced in the hypothalamus and transported to the pituitary gland through the blood stream. GnRH controls the secretion of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary. Secretion of GnRH is controlled by neural input from other parts of the brain and in females particularly, through negative feedback by the sex steroids. More potent analogues of GnRH (compared to endogenous GnRH) have been synthesized and are used to treat List of Gonadotropin releasing hormones Viadur Generic name: No reviews Vantas ( Generic name: No reviews Triptodur ( Generic name: No reviews Fensolvi Generic name: No reviews Factrel Generic name: No reviews Camcevi ( Generic name: No reviews For ratings, users were asked how effective they found the medicine while considering positive/adverse effects and ease of use (1 = not effective, 10 = most effective).