Is igm positive dangerous

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The gamma globulin band as seen in conventional serum protein electrophoresis consists of 5 immunoglobulins. In normal serum, about 5% is IgM. Elevations of IgM may be due to polyclonal immunoglobulin production. Monoclonal elevations of IgM occur in macroglobulinemia. Monoclonal gammopathies of all types may lead to a spike in the gamma globulin zone seen on serum protein electrophoresis. Decreased immunoglobulin levels are found in patients with congenital deficiencies. Increased serum immunoglobulin concentrations occur due to polyclonal or oligoclonal immunoglobulin proliferation in hepatic disease (eg, hepatitis, liver cirrhosis), connective tissue diseases, acute and chronic infections, as well as in the cord blood of neonates with intrauterine and perinatal infections. Elevation of IgM may occur in monoclonal gammopathies such as macroglobulinemia, primary systemic amyloidosis, monoclonal gammopathy of undetermined significance, and related disorders. Decreased levels are found in patients with primary or secondary immune deficiencies. Electrophoresis is usually required to interpret an elevated immunoglobulin class as polyclonal versus monoclonal. Immunofixation is usually required to characterize a monoclonal protein. If there is a discrete M-peak, the monoclonal protein can be monitored with quantitative immunoglobulins. If immunoglobulin quantitation is used to monitor the size of a monoclonal protein that is contained in a background of polyclonal immunoglobuli...

Overview Toxoplasmosis (tok-so-plaz-MOE-sis) is an infection with a parasite called Toxoplasma gondii. People often get the infection from eating undercooked meat. You can also get it from contact with cat feces. The parasite can pass to a baby during pregnancy. Most people infected with the parasite do not have symptoms. Some people get flu-like symptoms. Serious disease most often affects infants and people with weakened immune systems. Toxoplasmosis during pregnancy may cause miscarriage and birth defects. Symptoms Most people infected with toxoplasmosis do not have any symptoms. They often don't know they're infected. Some people have flu-like symptoms, including: • Fever. • Swollen lymph nodes that may last for weeks. • Headache. • Muscle aches. • Skin rash. Symptoms of eye disease The toxoplasma parasites may infect tissues of the inner eye. This can occur in people with healthy immune systems. But the disease is more serious in people with weakened immunity. An infection in the eye is called ocular toxoplasmosis. Symptoms may include: • Eye pain. • Poor vision. • Floaters, which are specks that seem to swim in your vision. Untreated eye disease can cause blindness. Effect on people with weakened immune systems People with weakened immune systems are likely to have more-serious disease from toxoplasmosis. A toxoplasmosis infection from earlier in life may become active again. People at risk include those living with HIV/AIDS, people receiving cancer treatment and peo...

Search this website Hide Search • About The Center • Meet Dr. Petri • Lupus Primer • Basics of Lupus • Causes of Lupus • Lupus Signs, Symptoms, and Co-occuring Conditions • How is lupus diagnosed? • How Lupus Affects the Body • Lifestyle and Additional Information • Lupus Disease Eduation Video Series • Lupus Tests • Antiphospholipid Antibodies • Lupus Blood Tests • Screening Laboratory Tests • Other Clinical Tests • Lupus Treatment • Lupus Medications and Treatment Options • Common Medications for Other Conditions in People with Lupus • Appointment Information Antiphospholipid antibodies are antibodies directed against phosphorus-fat components of your cell membranes called phospholipids, certain blood proteins that bind with phospholipids, and the complexes formed when proteins and phospholipids bind. Approximately 50% of people with lupus possesses these antibodies, and over a twenty-year period of time, one half of lupus patients with one of these antibodies—the lupus anticoagulant—will experience a blood clot. People without lupus can also have antiphospholipid antibodies. The most commonly discussed antiphospholipid antibodies are the lupus anticoagulant (LA) and anticardiolipin antibody (aCL). These two antibodies are often found together, but can also be detected alone in an individual. Other antiphospholipid antibodies include anti-beta 2 glycoprotein 1 (anti-ß2 GPI), anti-prothrombin, and the “false-positive” test for syphilis. Like other antibodies involved in l...