Lab diagnosis of syphilis

1 - 4 days Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary. Serological test for screening for syphilis infection. This panel includes a Treponema-specific test which may be positive in all stages of syphilis. It may be positive with treponemal infections other than syphilis (bejel, pinta, yaws). Like FTA-ABS and TP-PA, once positive, it remains so; it cannot be used to judge the effectiveness of treatment. The traditional syphilis screening approach when the first-line test is a nontreponemal assay (like RPR) and if positive, the second-line confirmatory test is a treponemal test (such as TP-PA) was developed many years ago when treponemal tests lacked necessary sensitivity but delivered acceptable specificity. In the early 1990s, the CDC published guidelines that recommended the traditional algorithm for screening. Since that time, a number of new, more sensitive treponemal immunoassays have been introduced. In 2008, the CDC issued a report that describes the new syphilis screening approach in which the treponemal test was used as the first-line test, and if positive, reflexes to the nontreponemal test. This report shows that a number of infected individuals would be missed using the traditional approach. In addition, a number of...

Only your doctor can know for sure whether you have syphilis. The USPSTF recommends that anyone who is at increased risk for infection undergo screening. Your doctor will give you a They can also diagnose syphilis by testing fluid from a sore. That’s rarely done. But I’ve Had Syphilis Before – Can I Get It Again? Yes. Even if you’ve had it and been treated, you can get it again by having And it’s important to know even if you don’t see sores, you’re not in the clear. Sores can hide inside your body. See your doctor right away if you’ve had sex with someone who has syphilis. Talk to your doctor about syphilis and other Talk to your doctor about testing and prevention of syphilis and other STDs if you’re sexually active. Doctors recommend syphilis testing if you’re: • A man who has sex with men • A • • Taking PrEP (Pre-Exposure Prophylaxis) for

If ARUP Consult does not answer your test selection and interpretation questions, or if you would like to suggest ways to improve content or usability, please send a message to the Consult editorial staff. Please do not include any patient-specific or personal health information (PHI) in your message. An email address is not required, but providing one allows the ARUP Consult editorial staffto respond directly. ARUP will only use your email address to respond to your feedback. See the CAPTCHA This question is for testing whether or not you are a human visitor and to prevent automated spam submissions. In the United States, two broad categories of serologic tests, treponemal and nontreponemal tests, are used in combination according to one of the two existing algorithms (traditional and reverse) to diagnose syphilis. Diagnosis requires the use of both types of tests. Either type of test can be used as the initial screening test or the confirmatory test; however, within the treponemal and nontreponemal test categories, certain tests are recommended for screening versus confirmation. Microscopic darkfield examination, a complex direct detection method, is unavailable in most laboratories. Syphilis can be detected by polymerase chain reaction (PCR), but clinical diagnostic PCR assays cleared by the U.S. Food and Drug Administration (FDA) are not yet available. Treponema pallidum cannot be cultured in most laboratories and cannot be viewed on a Gram stain. Serologic testing for...

Syphilis is a sexually transmitted disease with varied and often subtle clinical manifestations. Primary syphilis typically presents as a solitary, painless chancre, whereas secondary syphilis can have a wide variety of symptoms, especially fever, lymphadenopathy, rash, and genital or perineal condyloma latum. In latent syphilis, all clinical manifestations subside, and infection is apparent only on serologic testing. Late or tertiary syphilis can manifest years after infection as gummatous disease, cardiovascular disease, or central nervous system involvement. Neurosyphilis can develop in any stage of syphilis. The diagnosis of syphilis may involve dark-field microscopy of skin lesions but most often requires screening with a nontreponemal test and confirmation with a treponemal-specific test. Parenterally administered penicillin G is considered first-line therapy for all stages of syphilis. Alternative regimens for non-pregnant patients with no evidence of central nervous system involvement include doxycycline, tetracycline, ceftriaxone, and azithromycin. In pregnant women and patients with neurosyphilis, penicillin remains the only effective treatment option; if these patients are allergic to penicillin, desensitization is required before treatment is initiated. Once the diagnosis of syphilis is confirmed, quantitative nontreponemal test titers should be obtained. These titers should decline fourfold within six months after treatment of primary or secondary syphilis and...

Only your doctor can know for sure whether you have syphilis. The USPSTF recommends that anyone who is at increased risk for infection undergo screening. Your doctor will give you a They can also diagnose syphilis by testing fluid from a sore. That’s rarely done. But I’ve Had Syphilis Before – Can I Get It Again? Yes. Even if you’ve had it and been treated, you can get it again by having And it’s important to know even if you don’t see sores, you’re not in the clear. Sores can hide inside your body. See your doctor right away if you’ve had sex with someone who has syphilis. Talk to your doctor about syphilis and other Talk to your doctor about testing and prevention of syphilis and other STDs if you’re sexually active. Doctors recommend syphilis testing if you’re: • A man who has sex with men • A • • Taking PrEP (Pre-Exposure Prophylaxis) for

Syphilis is a sexually transmitted disease with varied and often subtle clinical manifestations. Primary syphilis typically presents as a solitary, painless chancre, whereas secondary syphilis can have a wide variety of symptoms, especially fever, lymphadenopathy, rash, and genital or perineal condyloma latum. In latent syphilis, all clinical manifestations subside, and infection is apparent only on serologic testing. Late or tertiary syphilis can manifest years after infection as gummatous disease, cardiovascular disease, or central nervous system involvement. Neurosyphilis can develop in any stage of syphilis. The diagnosis of syphilis may involve dark-field microscopy of skin lesions but most often requires screening with a nontreponemal test and confirmation with a treponemal-specific test. Parenterally administered penicillin G is considered first-line therapy for all stages of syphilis. Alternative regimens for non-pregnant patients with no evidence of central nervous system involvement include doxycycline, tetracycline, ceftriaxone, and azithromycin. In pregnant women and patients with neurosyphilis, penicillin remains the only effective treatment option; if these patients are allergic to penicillin, desensitization is required before treatment is initiated. Once the diagnosis of syphilis is confirmed, quantitative nontreponemal test titers should be obtained. These titers should decline fourfold within six months after treatment of primary or secondary syphilis and...

If ARUP Consult does not answer your test selection and interpretation questions, or if you would like to suggest ways to improve content or usability, please send a message to the Consult editorial staff. Please do not include any patient-specific or personal health information (PHI) in your message. An email address is not required, but providing one allows the ARUP Consult editorial staffto respond directly. ARUP will only use your email address to respond to your feedback. See the CAPTCHA This question is for testing whether or not you are a human visitor and to prevent automated spam submissions. In the United States, two broad categories of serologic tests, treponemal and nontreponemal tests, are used in combination according to one of the two existing algorithms (traditional and reverse) to diagnose syphilis. Diagnosis requires the use of both types of tests. Either type of test can be used as the initial screening test or the confirmatory test; however, within the treponemal and nontreponemal test categories, certain tests are recommended for screening versus confirmation. Microscopic darkfield examination, a complex direct detection method, is unavailable in most laboratories. Syphilis can be detected by polymerase chain reaction (PCR), but clinical diagnostic PCR assays cleared by the U.S. Food and Drug Administration (FDA) are not yet available. Treponema pallidum cannot be cultured in most laboratories and cannot be viewed on a Gram stain. Serologic testing for...

1 - 4 days Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary. Serological test for screening for syphilis infection. This panel includes a Treponema-specific test which may be positive in all stages of syphilis. It may be positive with treponemal infections other than syphilis (bejel, pinta, yaws). Like FTA-ABS and TP-PA, once positive, it remains so; it cannot be used to judge the effectiveness of treatment. The traditional syphilis screening approach when the first-line test is a nontreponemal assay (like RPR) and if positive, the second-line confirmatory test is a treponemal test (such as TP-PA) was developed many years ago when treponemal tests lacked necessary sensitivity but delivered acceptable specificity. In the early 1990s, the CDC published guidelines that recommended the traditional algorithm for screening. Since that time, a number of new, more sensitive treponemal immunoassays have been introduced. In 2008, the CDC issued a report that describes the new syphilis screening approach in which the treponemal test was used as the first-line test, and if positive, reflexes to the nontreponemal test. This report shows that a number of infected individuals would be missed using the traditional approach. In addition, a number of...

1 - 4 days Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary. Serological test for screening for syphilis infection. This panel includes a Treponema-specific test which may be positive in all stages of syphilis. It may be positive with treponemal infections other than syphilis (bejel, pinta, yaws). Like FTA-ABS and TP-PA, once positive, it remains so; it cannot be used to judge the effectiveness of treatment. The traditional syphilis screening approach when the first-line test is a nontreponemal assay (like RPR) and if positive, the second-line confirmatory test is a treponemal test (such as TP-PA) was developed many years ago when treponemal tests lacked necessary sensitivity but delivered acceptable specificity. In the early 1990s, the CDC published guidelines that recommended the traditional algorithm for screening. Since that time, a number of new, more sensitive treponemal immunoassays have been introduced. In 2008, the CDC issued a report that describes the new syphilis screening approach in which the treponemal test was used as the first-line test, and if positive, reflexes to the nontreponemal test. This report shows that a number of infected individuals would be missed using the traditional approach. In addition, a number of...

Only your doctor can know for sure whether you have syphilis. The USPSTF recommends that anyone who is at increased risk for infection undergo screening. Your doctor will give you a They can also diagnose syphilis by testing fluid from a sore. That’s rarely done. But I’ve Had Syphilis Before – Can I Get It Again? Yes. Even if you’ve had it and been treated, you can get it again by having And it’s important to know even if you don’t see sores, you’re not in the clear. Sores can hide inside your body. See your doctor right away if you’ve had sex with someone who has syphilis. Talk to your doctor about syphilis and other Talk to your doctor about testing and prevention of syphilis and other STDs if you’re sexually active. Doctors recommend syphilis testing if you’re: • A man who has sex with men • A • • Taking PrEP (Pre-Exposure Prophylaxis) for