Lscs full form

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Background: Leukaemia stem cells (LSCs) are responsible for the initiation, maintenance, and recurrence of acute myeloid leukaemia (AML), an aggressive haematological malignancy associated with drug resistance and relapse. Identifying therapeutic LSC targets is critical to curing AML. Methods Bioinformatics databases were used to identify therapeutic LSC targets. The conditional knockout mice were used to analyse the role of HCK in leukaemogenesis or normal haematopoiesis. Colony-forming assays, cell counting, and flow cytometry were used to detect the viability and function of leukaemia cells. RT-PCR, western blotting, and RNA sequencing were used to detect mRNA and protein expression. Result HCK is expressed at higher levels in LSCs than in haematopoietic stem cells (HSCs), and high HCK levels are correlated with reduced survival time in AML patients. Knockdown of HCK leads to cell cycle arrest, which results in a dramatic decrease in the proliferation and colony formation in human AML cell lines. Moreover, HCK is required for leukemogenesis and leukaemia maintenance in vivo and in vitro. HCK is necessary for the self-renewal of LSCs during serial transplantation and limiting dilution assay. The phenotypes resulting from HCK deficiency can be rescued by CDK6 overexpression in the human cell line. RNA sequencing and gene expression have demonstrated that HCK may sustain cell cycle entry and maintain the self-renewal ability of LSCs through activating the ERK1/2-c-Myc-CDK6...

What is the full form of LSCS LSCS: Lower Segment Caesarean Section LSCS stands for lower segment caesarean section. The most common kind of Caesarean section performed is called a Lower Segment Caesarean Section (LSCS). The lower uterine segment is usually cut transversely above the point where the urine bladder attaches to the uterus to deliver the baby. History And Origin German gynecologist Hermann Johannes Pfannenstiel invented the method. The procedure is commonly referred to as the Kerr incision, or the Pfannenstiel-Kerr cut in English-speaking nations, since Dr Monroe Kerr performed the process for the first time in Great Britain in 1911 and popularized it there. In 1920, Kerr reported that the previous technique harmed vascularized parts of the uterus more than a C-section. Vascularized parts of the uterus include the endometrium, myometrium and perimetrium. He claimed it was preferable to a longitudinal uterine cut in terms of scar rupture and artery damage. Forceps can be used to reduce bleeding since most bleeding occurs from the direction of the cut. Forceps from the Green Armytage line are made specifically for this use. Even though a sharp scalpel is used to cut, caution must be exercised to avoid harming the foetus, mainly if the membranes are burst or in situations like abruption. With the use of scissors or rough dissection with the hands, the cut can be stretched on either side. The gynaecologist should insert a finger below the uterus before using the s...

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* In present study among both group I and II it was seen that foetal distress was the common reason for LSCS, followed by failure of induction among group I, followed by maternal request, followed by non-decent of foetal head and non-progress of labour and one more reason was noticed among the group II females i.e. SAN DIEGO, Calif, January 17, 2013 -- Researchers at the University of California, San Diego School of Medicine have discovered that hard-to-reach, drug-resistant leukemia stem cells ( LSCs) that overexpress multiple pro survival protein forms are sensitive-and thus vulnerable to a novel cancer stem eel I-targeting drug under development.

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript. • Article • • 18 January 2021 Core transcription regulatory circuitry orchestrates corneal epithelial homeostasis • • • • • • • • • • • • • ORCID: orcid.org/0000-0002-1660-4728 • ORCID: orcid.org/0000-0002-4549-1697 • • ORCID: orcid.org/0000-0002-9936-882X • • ORCID: orcid.org/0000-0001-8636-6895 • … • ORCID: orcid.org/0000-0002-7622-7733 Show authors Nature Communications volume 12, Article number: 420 ( 2021) Adult stem cell identity, plasticity, and homeostasis are precisely orchestrated by lineage-restricted epigenetic and transcriptional regulatory networks. Here, by integrating super-enhancer and chromatin accessibility landscapes, we delineate core transcription regulatory circuitries (CRCs) of limbal stem/progenitor cells (LSCs) and find that RUNX1 and SMAD3 are required for maintenance of corneal epithelial identity and homeostasis. RUNX1 or SMAD3 depletion inhibits PAX6 and induces LSCs to differentiate into epidermal-like epithelial cells. RUNX1, PAX6, and SMAD3 (RPS) interact with each other and synergistically establish a CRC to govern the lineage-specific cis-regulatory atlas. Moreover, RUNX1 shapes LSC chromatin architecture via m...