Luliconazole cream uses

Luliconazole Luliconazole, an imidazole, is approved for the treatment of tinea infections (see Table 34-3). From: Pharmacology and Therapeutics for Dentistry (Seventh Edition), 2017 Related terms: • Liposome • Antifungal Activity • Antifungal Agent • Amphotericin B • Miconazole • Terbinafine • Mycosis • Imidazole • Tinea pedis • Candida Albicans Dayna S. McManus, in Side Effects of Drugs Annual, 2015 Luliconazole Luliconazole is an azole antifungal 1% cream available for the treatment of dermatophytoses. The structure and mechanism of action is similar to the other azole antifungals. A meta-analysis of six published randomized controlled trials reviewed the safety and efficacy of luliconazole cream. Luliconazole was not found have any statistically significant differences in adverse events when compared to other topical antifungals. No patients in the luliconazole group withdrew from therapy due to side effects and most adverse events that were reported were likely not due to the drug. The adverse events that did occur were contact dermatitis, irritation and pruritus. These events were considered to be of mild severity [ 24M]. Pobitra Borah, ... Pran Kishore Deb, in Medicinal Chemistry of Chemotherapeutic Agents, 2023 9.4.2.9Luliconazole Luliconazole ((2 E)-2-[(4 R)-4-(2,4-dichlorophenyl)-1,3-dithiolan-2-ylidene]-2-imidazol-1-ylacetonitrile) ( Fig. 9.13) was approved by the FDA (2013) for the treatment of tinea cruris, tinea pedis, and tinea corporis. Luliconazole possess...

Indications and Usage for Luzu Cream LUZU (luliconazole) Cream, 1% is indicated for the topical treatment of interdigital tinea pedis, tinea cruris, and tinea corporis caused by the organisms Trichophyton rubrum and Epidermophyton floccosum. Luzu Cream Dosage and Administration For topical use only. Luzu Cream, 1% is not for ophthalmic, oral, or intravaginal use. • When treating interdigital tinea pedis, a thin layer of Luzu Cream, 1% should be applied to the affected area and approximately 1 inch of the immediate surrounding area(s) once daily for 2 weeks. • When treating tinea cruris or tinea corporis, Luzu Cream, 1% should be applied to the affected area and approximately 1 inch of the immediate surrounding area(s) once daily for 1 week. Related/similar drugs Dosage Forms and Strengths Cream, 1%. Each gram of Luzu Cream, 1% contains 10 mg of luliconazole in a white cream base. Contraindications None. Adverse Reactions Clinical Trials Experience Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice. In three Phase 3 clinical trials, 616 subjects were exposed to Luzu Cream, 1%: 305 with interdigital tinea pedis and 311 subjects with tinea cruris. Subjects with interdigital tinea pedis or tinea cruris applied Luzu Cream, 1% or vehicle cream once daily for 14 days or 7...

What is this medication? LULICONAZOLE (lu LE KON a zole) is an antifungal medicine. It is used to treat certain kinds of fungal infections of the skin. This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions. COMMON BRAND NAME(S): LUZU What should I tell my care team before I take this medication? They need to know if you have any of these conditions: • an unusual or allergic reaction to luliconazole, other medicines, foods, dyes or preservatives • pregnant or trying to get pregnant • breast-feeding How should I use this medication? This medicine is for external use only. Do not take by mouth. Follow the directions on the label. Wash hands before and after use. Apply a thin layer of medicine to cover the affected skin and surrounding area. Do not use your medicine more often than directed. Finish the full course prescribed by your doctor or health care professional even if you think your condition is better. Do not stop using except on the advice of your doctor or health care professional. Talk to your pediatrician regarding the use of this medicine in children. While this drug may be prescribed for children as young as 2 years for selected conditions, precautions do apply. Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once. NOTE: This medicine is only for you. Do not share this medicine with others. What if I miss a dose? If you miss a dose, use...

Luliconazole Uses Use luliconazole as instructed by your doctor. Read all the details you have given. Follow all directions carefully. Don't take luliconazole by mouth. Use only on your skin. Keep out of your mouth, your nose, and your eyes (may burn). Before and after use, wash your face. After use do not wash your hands if you put it on your hand.Clean the affected component prior to use. Make sure you dry well. Put a thin film on the affected portion and massage it gently. Use as you've been told, even if your signs get stronger. Luliconazole Cream Uses: Read the Patient Information, if available from your doctor or pharmacist, before you start using luliconazole and any time you refill. Ask your doctor or pharmacist if you have any queries regarding this medication. This drug is for use on the skin only. Wash and dry your hands before administering the drug, and then clean and dry the affected region. Apply a thin film of the drug to the infected area and some of the surrounding skin and gently massage as instructed by your doctor, generally once a day. The period of treatment depends on the type of infection being treated. Never use this more frequently than prescribed and required. Your condition will not clear up sooner, and your risk of side effects will increase. • Clean your hands after applying the drug. Do not cover, bandage, or wrap the area unless instructed by your doctor. • Do not use this medicine on the eyes, mouth, or vagina. • Use this drug daily to mak...

• Luliconazole helps treat skin infections caused by many different types of fungi. • Few healthy tips for Athlete's Foot: • Keep your feet clean and dry, particularly between the toes. • Cut your nails short and prefer open-toe shoes for everyday use. • Use a separate clean towel for the feet and wear clean cotton socks. • Never share your socks, shoes, and towel with others. • Apply an amount sufficient to cover the affected area and 1 inch of the immediate surrounding skin. • It can take a few weeks for the infection to clear and a few months before the skin returns to its normal color. • Finish the full course of treatment even if you feel better. • It is not taken orally, so it does not cause many side effects. • Avoid getting it in the eyes, nose, or mouth. If accidental exposure occurs, rinse immediately with plenty of water. • Inform your doctor if the infection has not cleared up after four weeks of treatment. Q. How to use Luliconazole? Use Luliconazole exactly as per your doctor’s advice. If you have an athlete's foot between the toes, apply a thin layer of this medicine to the affected skin areas and spread it to cover at least 1 inch of the surrounding skin. Use it once a day for 2 weeks. If you have jock itch or ringworm, apply it to the affected skin areas and spread it to cover at least 1 inch of the surrounding skin. Use it once a day for 1 week. Always wash your hands after you apply this medicine. Q. How long does it take for Luliconazole to work? For di...

Luliconazole (Topical application) Generic name: luliconazole [ loo-li-KON-a-zole] Drug class: • • • • • Uses for luliconazole Luliconazole topical cream is used to treat infections caused by a fungus or yeast. It works by killing the fungus or yeast or preventing its growth. Luliconazole cream is used to treat: • Ringworm of the body (tinea corporis); • Ringworm of the foot between the toes (interdigital tinea pedis, athlete's foot); and • Ringworm of the groin (tinea cruris, jock itch). This medicine is available only with your doctor's prescription. Before using luliconazole In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered: Allergies Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully. Pediatric Appropriate studies have not been performed on the relationship of age to the effects of luliconazole topical cream in children younger than 12 years of age to treat tinea pedis and tinea cruris and in children younger than 2 years of age to treat tinea corporis. Safety and efficacy have not been established. Geriatric Appropriate studies performed to...

Luzu Generic Name Luliconazole DrugBank Accession Number DB08933 Background Luliconazole is a topical antifungal agent that acts by unknown mechanisms but is postulated to involve altering the synthesis of fungi cell membranes. It was approved by the FDA (USA) in November 2013 and is marketed under the brand name Luzu. Luliconazole is also approved in Japan. Type Small Molecule Groups Approved Structure Learn more Pharmacodynamics Luliconazole kills the organisms Trichophyton rubrum and Epidermophyton floccosum, most likely by altering their fungal cell membranes. Mechanism of action The exact mechanism of action for luliconazole's anti-fungal activity is still not known, but luliconazole is thought to inhibit the enzyme lanosterol demethylase. Lanosterol demethylase is needed for the synthesis of ergosterol, which is a major component of the fungus cell membranes. Target Actions Organism A inhibitor Yeast Absorption Although luliconazole is administered topically, clinical studies have shown that after the first dose in patients with tina pedis, a maximum plasma concentration of 0.40 ± 0.76 ng/mL (mean ± SD) occurred in 16.9 ± 9.39 hours (mean ± SD). Volume of distribution The volume of distribution was not quantified. Protein binding Plasma protein binding of luliconazole is >99%. Metabolism The metabolism of luliconazole has yet to be determined. Route of elimination The route of elimination of luliconazole has yet to be determined. Half-life The half life of luliconazo...