Methergine injection uses

What Is Methylergometrine And What It Used For? Mainly Methylergometrine most people known as partial agonist and antagonist of the serotonin and dopamine drugs or a-adrenergic receptor which also known with some other names like • Methylergonovine • Methylergobasin • Methylergobasine It generally belong from the drug class of ergoline and lysergamide medications. Mainly it shows the psychedelic effects which used for the treatment of oxytocic in obstetrics as well as for cure of migraine. Moreover, the medicine first discovered during studies in USA in year 1985. However they first approved to use it in medicine in the year 2000. Tablets Injection Of Methergin Composition Formula Ingredients • Methergin Tablets : Contains Methylergometrine Maleate = 0.125 MG • Methergin Injection: Contains Methylergometrine Maleate = 0.2 mg/ml Methergine Tablet Injections Uses & Indications • Active management of the third stage of labor ( as a means to promote separation of the placenta and to reduce blood loss). • It used for the treatment of uterine atony, hemorrhage occurring during or after the third stage of labor, in association with cesarean section or following • For the treatment of sub involution of the uterus, lochiometra, puerperal bleeding. Uses In Urdu Hindi Methergine Tablets Injection Dosage And Administration Active management of the third stage of labor Intramuscular injection (i.m.) is the recommended route of administration. However, when administered (i.v.) the Methe...

What Is Pitocin? Pitocin ( What Are Side Effects of Pitocin? Common side effects of Pitocin include: • redness or irritation at the injection site, • loss of appetite, • nausea, • vomiting, • cramping, • stomach pain, • more intense or more frequent contractions (this is an expected effect of oxytocin), • • • memory problems. Tell your doctor if you experience serious side effects of Pitocin including: • fast, slow, or uneven heart rate; • excessive bleeding long after childbirth; • headache, • confusion, • slurred speech, • hallucinations, • severe vomiting, • severe weakness, • muscle cramps, • loss of coordination, • feeling unsteady, • • • shallow breathing or breathing that stops; or • dangerously Dosage for Pitocin Pitocin is administered under a physician's supervision. The initial dose of Pitocin should be 0.5-1 mU/min (equal to 3-6 mL of the dilute oxytocin solution per hour). At 30-60 minute intervals the dose should be gradually increased in increments of 1-2 mU/min until the desired contraction pattern has been established. What Drugs, Substances, or Supplements Interact with Pitocin? Pitocin may interact with drugs used in Pitocin During Pregnancy and Breastfeeding Pitocin should be used during pregnancy only if prescribed. There are no known indications for use of this medication in the first 3 months of pregnancy other than in relation to spontaneous or Additional Information Our Pitocin (oxytocin injection, USP) Side Effects Drug Center provides a comprehen...

Remember that this Tell your doctor right away if you have any serious side effects, including: fast/slow heartbeat, shortness of breath, cold hands/feet, pain/redness/swelling of arms or legs. Get medical help right away if you have any very serious side effects, including: A very serious This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist. In the US - Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch. In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Methergine (Oral) Generic name: methylergonovine [ meth-il-er-goe-NOE-veen] Drug class: • • • • • Uses for Methergine Methylergonovine is used to prevent and control bleeding from the uterus that can happen after childbirth. It belongs to the class of medicines called ergot alkaloids. This medicine works by acting directly on the smooth muscles of the uterus and prevents bleeding after giving birth. This medicine is available only with your doctor's prescription. Before using Methergine In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered: Allergies Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully. Pediatric Appropriate studies have not been performed on the relationship of age to the effects of methylergonovine in the pediatric population. Safety and efficacy have not been established. Geriatric Although appropriate studies on the relationship of age to the effects of methylergonovine have not been performed in the geriatric population, no geriatric-specific problems have been documented to date. However, elderly patients are more likely to have...

Table of Contents • • • • • • • • • • • • • • • • • • • • • • • • Why Methergine is given after abortion? Methylergonovine is used just after a baby is born, to help deliver the placenta (also called the afterbirth). It is also used to help control bleeding and to improve muscle tone in the uterus after childbirth. When should you not give Methergine? blockage or narrowing of mitral heart valve. high blood pressure. a heart attack. coronary artery disease. What is Methergine used for miscarriage? Methergine, a uterotonic, along with another medication, misoprostol, is commonly used for Early Pregnancy Loss hemorrhage. Methergine has a rapid onset of 5-10 minutes, and is an appropriate first-line agent to manage early pregnancy loss hemorrhage. When do you use Methergine? This medication is used after childbirth to help stop bleeding from the uterus. Methylergonovine belongs to a class of drugs known as ergot alkaloids. It works by increasing the rate and strength of contractions and the stiffness of the uterus muscles. Read More: What is magnetic moment of a nucleus? How long do you bleed after taking Methergine? Bleeding may be light or heavy; you should not soak more than 2 maxi-pads an hour for 2 or more hours in a row. Bleeding usually lasts about 2 to 4 weeks. How often can Methergine be given? May be repeated as required, at intervals of 2-4 hours. 1 mL, 0.2 mg, administered slowly over a period of no less than 60 seconds (See WARNINGS.) One tablet, 0.2 mg, 3 or 4 ti...

Key:UNBRKDKAWYKMIV-QWQRMKEZSA-N N N Y Methylergometrine, also known as methylergonovine and sold under the brand name Methergine, is a medication of the [ citation needed] It is on the Medical uses [ ] Obstetric use [ ] Methylergometrine is a smooth muscle constrictor that mostly acts on the Migraine [ ] Methylergometrine is sometimes used for both prevention Contraindications [ ] Methylergometrine is contraindicated in patients with 2A–mGlu2 receptor protomer and increases the chances of a patient experiencing hallucinations during methylergometrine therapy). Side effects [ ] Adverse effects include: • Nausea, vomiting, and diarrhea • Dizziness • Pulmonary hypertension [ citation needed] • Coronary artery vasoconstriction • Severe systemic hypertension (especially in patients with • Convulsions In excessive doses, methylergometrine can also lead to cramping, Interactions [ ] Methylergometrine likely interacts with drugs that inhibit the liver enzyme Pharmacology [ ] Pharmacodynamics [ ] Methylergometrine is an 2A receptors, 1A, 1B, 1E, 1F, 2A, 2B, 2C, 5A, and 7 receptors. Methylergometrine is a 2A– [ citation needed] Clinical efficacy occurs around 200µg, ten times lower than the hallucinogenic threshold. Methylergometrine is an agonist of the serotonin 5-HT 2B receptor and is maybe linked to Activities of methylergometrine at various sites Site Affinity (K i [nM]) Efficacy (E max [%]) Action 1A 1.5–2.0 ? Full agonist 1B 251 ? Full agonist 1D 0.86–2.9 70 Partial agonist 1...

Postpartum hemorrhage, the loss of more than 500 mL of blood after delivery, occurs in up to 18 percent of births and is the most common maternal morbidity in developed countries. Although risk factors and preventive strategies are clearly documented, not all cases are expected or avoidable. Uterine atony is responsible for most cases and can be managed with uterine massage in conjunction with oxytocin, prostaglandins, and ergot alkaloids. Retained placenta is a less common cause and requires examination of the placenta, exploration of the uterine cavity, and manual removal of retained tissue. Rarely, an invasive placenta causes postpartum hemorrhage and may require surgical management. Traumatic causes include lacerations, uterine rupture, and uterine inversion. Coagulopathies require clotting factor replacement for the identified deficiency. Early recognition, systematic evaluation and treatment, and prompt fluid resuscitation minimize the potentially serious outcomes associated with postpartum hemorrhage. Clinical recommendation Evidence rating References Active management of the third stage of labor decreases postpartum blood loss and the risk of postpartum hemorrhage (number needed to treat=12). A , Active management of the third stage of labor does not increase the risk of retained placenta. A , , Oxytocin (Pitocin) is the first choice for prevention of postpartum hemorrhage because it is as effective or more effective than ergot alkaloids or prostaglandins and has f...

Dosage Forms & Strengths injectable solution • 0.2mg/mL tablet • 0.2mg Postpartum Hemorrhage 0.2 mg IM/IV q2-4hr PRN; not to exceed 5 doses, THEN 0.2-0.4 mg PO q6-8hr PRN for 2-7 days Administer IV only in emergency because of potential for Hypertension & CVA Administer over >1 minute and monitor BP Refractory Cluster Headache (Off-label) 0.2 mg PO q6-8hr, not to exceed 6 months Contraindicated (37) • almotriptan methylergonovine, almotriptan. Either increases toxicity of the other by pharmacodynamic synergism. Contraindicated. Additive vasospasm. Sep. by 24h. • atazanavir atazanavir will increase the level or effect of methylergonovine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. • ceritinib ceritinib will increase the level or effect of methylergonovine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. • clarithromycin clarithromycin will increase the level or effect of methylergonovine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. • cobicistat cobicistat will increase the level or effect of methylergonovine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Potential for serious and/or life-threatening reactions (eg, acute ergot toxicity characterized by peripheral vasospasm, ischemia of the extremities and other tissues) • conivaptan conivaptan will increase the level or effect of methylergonovine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contrain...