Montelukast & levocetirizine dihydrochloride suspension

Singulair Generic name: mon-te-LOO-kast] Drug class: Medically reviewed by • • • • • • • What is Singulair? Singulair is a leukotriene (loo-koe-TRY-een) inhibitor. Leukotrienes are chemicals your body releases when you breathe in an allergen (such as pollen). These chemicals cause swelling in your lungs and tightening of the muscles around your airways, which can result in Singulair is used to prevent asthma attacks in adults and children as young as 12 months old. Singulair is also used to prevent exercise-induced bronchoconstriction (narrowing of the air passages in the lungs) in adults and children who are at least 6 years old. Singulair is also used to treat symptoms of year-round (perennial) Singulair is used for allergies, only after other treatments have failed. If you already take Singulair to prevent asthma or allergy symptoms, do not use an extra dose to treat exercise-induced bronchoconstriction. Warnings Some people using Singulair have had new or worsening mental problems. Stop taking montelukast and call your doctor right away if you have any unusual changes in mood or behavior (such as anger, aggression, confusion, sleep problems, compulsive behaviors, hallucinations, or suicidal thoughts or actions). Tell your doctor right away if you have signs of blood vessel inflammation: flu-like symptoms, severe sinus pain, a Singulair will not work fast enough to treat an asthma attack that has already begun. Use only a fast-acting inhalation medicine to treat an asth...

Add a drug to check interactions Add • • View (4) Most frequently checked interactions View interaction reports for montelukast and the medicines listed below. • Major • Moderate • Minor • Unknown • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • Montelukast disease interactions There are • • • •

• Corine Ekhart , pharmacist 1, • Florence van Hunsel , pharmacist, epidemiologist 1, • Vanessa Sellick , administrator of the Montelukast Side Effects Support and Discussion Group 2, • Tjalling de Vries , paediatrician 3 • 1Netherlands Pharmacovigilance Centre Lareb, 's-Hertogenbosch, The Netherlands • 2Montelukast (Singulair) Side Effects Support and Discussion Group, International Group, Melbourne, Victoria, Australia • 3Department of Paediatrics, Medical Centre Leeuwarden (MCL), Leeuwarden, The Netherlands • Corresponding author: C Ekhart c.ekhartlareb.nl What you need to know • Montelukast, used in the treatment of asthma and allergic rhinitis, can cause serious mental health adverse effects such as nightmares, aggression, depression, and suicidal ideation • These adverse effects have been reported in patients of all ages, with and without pre-existing psychiatric disease, while taking montelukast or rarely after discontinuation • Inform patients and carers of these adverse reactions by discussing the patient information leaflet at the time of prescribing montelukast, and review within one month of initiation and regularly thereafter A 13 year old boy was started on 5 mg montelukast daily in addition to low dose inhaled corticosteroids to treat his asthma. Within a few days, his mother noted that he was constantly arguing and wanted to hit and kick other people. He had not shown this behaviour earlier. At the time of prescribing, their doctor had asked for any history...

Overview: Montelukast was introduced in 1990, and it was approved for clinical use by the FDA (Food and Drug Administration) with the brand name Singulair. This drug belongs to the class leukotriene receptor antagonist (LTRA). Leukotrienes are chemical substances that the body releases when inhaling allergens. As it was realized that cysteinyl leukotrienes are essential mediators of bronchial asthma, efforts were made to develop their antagonists and synthesis inhibitors. Now, three leukotriene receptor antagonists, Montelukast, Pranlukast, and Zafirlukast, are available. Montelukast is used in addition to inhaled corticosteroids, demonstrating its effectiveness in asthma therapy. In addition, it may cause serious life-threatening mental changes when it is misused or stopped abruptly. Composition: This tablet contains • Active Ingredient: Montelukast sodium. • Inactive Ingredients: • Microcrystalline cellulose. • Lactose monohydrate. • Croscarmellose sodium. • Hyprolose. • Magnesium stearate. Drug Group: Montelukast belongs to the class of drugs called leukotriene receptor antagonists (LRAs). This drug stops the narrowing of airways caused by inflammation, thus promoting easier breathing. Also, it helps to prevent episodes of asthma and other allergies. What Is Montelukast Used For? The uses of Montelukast are as follows, • Prophylactic in Bronchial Asthma: It helps • Mild to Moderate Asthma - It is used as an alternative to inhaled Glucocorticoids. Though efficacy is low,...

Montelukast: 7 things you should know Medically reviewed by • • • • • • • 1. How it works • Montelukast may be used for the treatment of asthma or allergic rhinitis. It inhibits bronchoconstriction, which is the narrowing of the airways resulting in breathing difficulties. • Montelukast inhibits specific receptors in the airways called cysteinyl leukotriene (CysLT) receptors, specifically CysLT-1. These receptors are affected by substances called cysteinyl leukotrienes (LTDs), which are released during inflammation and following exposure to an allergen. By blocking these receptors, montelukast inhibits the actions of LTD-4 and prevents the development of edema, smooth muscle constriction, and inflammation. This relaxes the airways, relieves edema, and dampens down redness and irritation. • Montelukast belongs to the class of medicines known as leukotriene receptor antagonists (LTRAs). 2. Upsides • Used for the maintenance treatment of asthma in adults and children aged older than 12 months. • May also be used to treat exercise-induced bronchospasm (EIB) (this is shortness of breath that occurs only during exercise) in adults and children aged six years and older. • Can help relieve symptoms of seasonal allergic rhinitis in adults and children over the age of two and perennial allergic rhinitis in those over the age of 6 months. • Has a preference for inhibiting CysLT-1 receptors over other receptors (such as prostanoid, cholinergic, or beta-adrenergic receptors). • Availab...