Montelukast sodium and levocetirizine hydrochloride tablets uses

There is no data to prove the overdosage of this combination. However, overdosage has been reported with individual molecules. Montelukast: There have been reports of acute overdosage in post-marketing experience and clinical studies with Montelukast. These include reports in adults and children with a dose as high as 1000mg. The clinical and laboratory findings observed were consistent with the safety profile in adults and pediatric patients. There were no adverse experiences in the majority of overdosage reports. The most frequently occurring adverse experiences were consistent with the safety profile of Montelukast and included abdominal pain, somnolence, thirst, headache, vomiting, and psychomotor hyperactivity. It is not known whether Montelukast is removed by the peritoneal dialysis or hemodialysis. Levocetirizine: Symptoms of overdose may include drowsiness in adults and initially agitation and restlessness followed by drowsiness in children. There is no known specific antidote to Levocetiriane. Shoould overdose occur, symptomatic or supportive treatment is recommended. Levocetirizine is not effectively removed by dialysis and dialysis will be ineffective unless a dialyzable agent has been concomitantly ingested. Montelukast: Eosinophilic Conditions: In rare cases, patients on therapy with Montelukast may present with systemic, eosinophilia, sometimes presenting with clinical features of vasculitis consistent with Churg-Strauss syndrome, a condition which is often t...

Levocetirizine 5mg and Montelukast 10mg Tablets Taj Pharma COMPOSITION: Each film-coated tablet contains: Montelukast Sodium equivalent to Montelukast 10mg Levocetirizine Hydrochloride 5mg Excipients q.s. DOSAGE FORM: Tablet DESCRIPTION: Montelukast Sodium is an orally active compound that binds with high affinity and selectivity to the CysLT type-1 (CysLT 1) receptor. Montelukast inhibits physiologic actions of LTD 4 at the CysLT1 receptor without any agonist activity. It therefore acts as a leukotriene receptor antagonist Levocetirizine, the active enantiomer of cetirizine, is an antihistamine and selective antagonist of H 1-receptors. It has been demonstrated by recent studies that the treatment of allergic rhinitis (AR) with concomitant administration of an anti-leukotriene (montelukast) and an antihistamine (levocetirizine), shows significantly better symptom relief compared with the modest improvement of rhinitis symptomatology with each of the treatments alone. PHARMACOLOGY: The pharmacological properties of Levocetirizine and Montelukast are given separately: Pharmacodynamics: Montelukast The cysteinyl leukotrienes (LTC 4, LTD 4, LTE 4) are products of arachidonic acid metabolism and are released from various cells including mast cells and eosinophils. These eicosanoids bind to cysteinyl leukotriene (CysLT) receptors. The CysLT type-1 (CysLT 1) receptor is found in the human airway (including airway smooth muscle cells and airway macrophages) and on other pro-infla...