Ofloxacin tablet uses

What is this medication? OFLOXACIN (oh FLOKS a sin) treats infections caused by bacteria. It belongs to a group of medications called quinolone antibiotics. It will not treat colds, the flu, or infections caused by viruses. This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions. COMMON BRAND NAME(S): Floxin What should I tell my care team before I take this medication? They need to know if you have any of these conditions: • Bone problems • Diabetes • Heart disease • High blood pressure • History of irregular heartbeat • History of low levels of potassium in the blood • Joint problems • Kidney disease • Liver disease • Mental illness • Myasthenia gravis • Seizures • Tendon problems • Tingling of the fingers or toes, or other nerve disorder • An unusual or allergic reaction to ofloxacin, fluoroquinolone antibiotics, foods, dyes, or preservatives • Pregnant or trying to get pregnant • Breast-feeding How should I use this medication? Take this medication by mouth with a full glass of water. Follow the directions on the prescription label. You can take it with or without food. If it upsets your stomach, take it with food. Take your medication at regular intervals. Do not take your medication more often than directed. Take all of your medication as directed even if you think you are better. Do not skip doses or stop your medication early. Avoid taking didanosine, sucralfate, antacids, or iron or zinc products within 2 hou...

Learn more Pharmacodynamics Ofloxacin is a quinolone/fluoroquinolone antibiotic. Ofloxacin is bactericidal and its mode of action depends on blocking of bacterial DNA replication by binding itself to an enzyme called DNA gyrase, which allows the untwisting required to replicate one DNA double helix into two. Notably the drug has 100 times higher affinity for bacterial DNA gyrase than for mammalian. Ofloxacin is a broad-spectrum antibiotic that is active against both Gram-positive and Gram-negative bacteria. Mechanism of action Ofloxacin acts on DNA gyrase and toposiomerase IV, enzymes which, like human topoisomerase, prevents the excessive supercoiling of DNA during replication or transcription. By inhibiting their function, the drug thereby inhibits normal cell division. Target Actions Organism A inhibitor Humans Absorption Bioavailability of ofloxacin in the tablet formulation is approximately 98% Volume of distribution Not Available Protein binding 32% Metabolism Hepatic Route of elimination Ofloxacin is mainly eliminated by renal excretion, where between 65% and 80% of an administered oral dose of ofloxacin is excreted unchanged via urine within 48 hours of dosing. About 4-8% of an ofloxacin dose is excreted in the feces and the drug is minimally subject to biliary excretion. Half-life 9 hours Clearance Not Available Adverse Effects The therapeutic efficacy of Acarbose can be increased when used in combination with Ofloxacin. Aceclofenac may increase the neuroexcitator...

Ofloxacin & Ornidazole Tablet Ofloxacin: It is active after oral administration. It inhibits bacterial DNA replication by blocking DNA topo-isomerases, in particular DNA gyrase. Omidazole: After passive absorption inte bacterium cell, the nitro group of Omidazole is reduced to amine group by ferredoxin type redox system. The formation of redox intermediate intracellular metabolites is believed to be the key component of microorganism killing for Omnidazole. The mechanism of action is similar in protozoa. Microbiology: Microbiclogical results indicate that the following pathogens may be regarded as sensitive: Staphylococcus aureus (including methicillin resistant staphylococci), Staphylococcus epidermidis, Neisseria species, Escherichia coli, Citrobacter, Klebsiella, Enterobacter, Hafnia, Proteus (indole- negative and indole-positive strains), Haemophilus influenzae, Chlamydiae, Legionella, Gardnerella. Variable sensitivity is shown by Streptococci, Serratia marcescens, Pseudomonas aeruginosa and Mycoplasmas. Anaerobic bacteria (e.g. Fusobacterium species, Bacteroides species, Eubacterium species, Peptococci, Peptostreptococci) are normally resistant. Ofloxacin is not active against Treponema pallidum. Pharmacokinetics: Ofloxacin: Ofloxacin is almost completely absorbed after oral administration. Maximal blood levels occur 1-3 hours after dosing and the elimination half-life is 4-6 hours. Ofloxacin is primarily excreted unchanged in the urine. In renal insufficiency the dos...

Dosage Forms & Strengths tablet • 200mg • 300mg • 400mg Bronchitis Exacerbation 400 mg PO q12hr for 10 days Limitations-of-use: Reserve antimicrobials#fluoroquinolones for patients who do not have other available treatment options for acute bacterial exacerbation of chronic bronchitis Community Acquired Pneumonia 400 mg PO q12hr for 10 days Skin & Skin Structure Infections 400 mg PO q12hr for 10 days Acute, Uncomplicated Urethral and Cervical Gonorrhea No longer recommended for gonorrhea owing to widespread resistance in the US 400 mg PO single dose Nongonococcal Cervicitis/Urethritis or Mixed Infection of Cervix/Urethra 300 mg PO q12hr for 7 days Acute Pelvic Inflammatory Disease 400 mg PO q12hr for 10-14 days Uncomplicated Cystitis Due to E. coli or K. pneumoniae: 200 mg PO q12hr for 3 days Due to other approved pathogens: 200 mg PO q12hr for 7 days Limitations-of-use: Reserve antimicrobials#fluoroquinolones for patients who do not have other available treatment options for uncomplicated urinary tract infections Complicated UTIs 200 mg PO q12hr for 10 days Prostatitis Due to E. Coli 300 mg PO q12hr for 6 weeks Traveler's Diarrhea (Off-label) 300 mg PO q12hr for 1-3 days Dosage Modifications Renal impairment • CrCl 20-50 mL/min: Give q24hr • CrCl <20 mL/min: Give one-half usual dose q24hr Other Indications and Uses Mild to moderate infection due to susceptible strains of designated microorganisms Chlamydia trachomatis, Citrobacter spp, Enterobacter spp, E. coli, Klebsiell...

What Are Dosages of Ofloxacin? Dosages of Ofloxacin: Dosage Forms and Strengths Tablet • 200 mg • 300 mg • 400 mg Dosage Considerations – Should be Given as Follows: Bronchitis Exacerbation • 400 mg orally every 12 hours for 10 days • Limitations-of-use: Reserve fluoroquinolones for patients who do not have other available treatment options for acute bacterial exacerbation of Community- • 400 mg orally every 12 hours for 10 days Skin and Skin Structure Infections • 400 mg orally every 12 hours for 10 days Acute, Uncomplicated Urethral and • No longer recommended for gonorrhea due to widespread resistance in the U.S. • 400 mg orally single dose Non-gonococcal • 300 mg orally every 12 hours for 7 days Acute Pelvic Inflammatory Disease • 400 mg orally every 12 hours for 10-14 days Uncomplicated • Due to E. coli or K. pneumoniae: 200 mg orally every 12 hours for 3 days • Due to other approved pathogens: 200 mg orally every 12 hours for 7 days • Limitations-of-use: Reserve fluoroquinolones for patients who do not have other available treatment options for uncomplicated urinary tract infections Complicated Urinary Tract Infections (UTIs) • 200 mg orally every 12 hours for 10 days Prostatitis Due to E. coli • 300 mg orally every 12 hours for 6 weeks Traveler's Diarrhea (Off-label) • 300 mg orally every 12 hours for 1-3 days Dosage Modifications Renal impairment • CrCl 20-50 mL/min: Give every 24 hours • CrCl less than 20 mL/min: Give one-half usual dose every 24 hours Other Indic...