Olanzapine

Add a drug to check interactions Add • • View (4) • View (19) Most frequently checked interactions View interaction reports for olanzapine and the medicines listed below. • Major • Moderate • Minor • Unknown • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • Olanzapine alcohol/food interactions There are Olanzapine disease interactions There are • • • • • • • • • • • • • • • • • • • Drug Interaction Classification These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication. Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. Unknown No interaction information available. Further information Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

This medicine should come with a Medication Guide. Read and follow the instructions carefully. Ask your doctor or pharmacist if you have any questions. Ask your pharmacist for the medication guide if you do not have one. If you are using the orally disintegrating tablet (Zyprexa® Zydis®), make sure your hands are dry before you handle the tablet. Do not open the blister pack that contains the tablet until you are ready to take it. Remove the tablet from the blister pack by peeling back the foil, then taking the tablet out. Do not push the tablet through the foil. Place the tablet in your mouth. It should melt quickly. After the tablet has melted, swallow or take a sip of water. You may take this medicine with or without food. Tell your doctor if you smoke tobacco. You might need a different amount of this medicine if you smoke. Dosing The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so. The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine. • For oral dosage forms (orally disintegrating tablets, regular tablets): • For treatment of sc...

olanzapine Olanzapine is a You can find detailed information about this drug in the official Patient Information Leaflet (PIL). This includes information on what the medication is for, how to take it, possible side effects and safety information. This leaflet should come with your medication, usually inside the box. Or you can download a PDF version of the PIL for your medication: • • • Some drugs come in different forms, such as tablets or liquid. There may be a separate PIL for each form of the drug, as well as for different doses. You should look at the PIL for the form and dose you have been prescribed. You can also search these websites for your specific drug to find further information and PILs: • • • If you have any questions about your medication you can: • talk to your doctor, or any healthcare professional who prescribes your medication • speak to someone at a pharmacy • contact • contact If you experience any side effects from your drug, you can report them to the MHRA via their Note: • Please don’t include personal details like your name or email address. If you do, data protection law means we’ll have to delete your comments. • Unfortunately we can’t reply to this. If you want a response from us, see our • If you are in crisis right now and want to talk to someone urgently then you could call Samaritans on 116 123 (freephone). Our pages on

Introduction with a case An elderly woman was admitted to the ICU for COPD exacerbation requiring BiPAP. Her COPD improved but she developed delirium. She was increasingly agitated, attempting to remove her oxygen and intravenous lines. She received 4 mg IV haloperidol, but continued to be agitated. Eventually after titration to a total of 12 mg IV haloperidol she became somnolent. At that point it was noted that despite her sleeping, she manifested myoclonic jerking of her extremities (a new finding). What happened? With hindsight, it is likely that she began experiencing akathisia as a side effect of the IV haloperidol used to sedate her (which caused worsening restlessness, agitation, and myoclonic jerking). This is a potential pitfall of using haloperidol for treatment of agitation, because akathisia may actually exacerbate the patient’s agitation, leading to a vicious cycle involving further haloperidol administration. Diagnosing akathisia in an agitated patient can be difficult. How could this complication be avoided in the future? (1) The evolution of intravenous olanzapine Technically, haloperidol is not FDA-approved for intravenous use. However, shortly after intramuscular haloperidol was released, physicians realized that it could be given intravenously. Over time, IV haloperidol became widespread and accepted. Olanzapine (ZYPREXA) seems to be undergoing a similar process. Although olanzapine isn’t FDA-approved for intravenous administration, it is increasingly r...

Olanzapine is a generic prescription medication used to treat certain mental health conditions. Specifically, it’s approved to treat: • • manic and mixed episodes related to • depressive episodes related to bipolar I disorder in adults and children ages 10 years and older • resistant For manic and mixed episodes related to bipolar disorder, you may use olanzapine on its own or with lithium or valproate. For depressive episodes related to bipolar disorder and treatment-resistant depression, you may use olanzapine with fluoxetine ( To learn more about olanzapine uses, see “ Drug details Olanzapine belongs to a drug class called atypical or It comes as an oral tablet and an orally disintegrating tablet. Olanzapine also comes in an injectable form, but this article does not cover it. Your doctor can tell you more about this form. Olanzapine tablets are available in the following strengths: • oral tablets: 2.5 milligrams (mg), 5 mg, 7.5 mg, 10 mg, 15 mg, 20 mg • orally disintegrating tablets: 5 mg, 10 mg, 15 mg, 20 mg Brand-name versions The brand-name version of olanzapine is Zyprexa. Olanzapine is a generic drug. A generic drug is an exact copy of the active drug in a brand-name medication. Zyprexa is the brand-name medication that olanzapine is based on. A generic is considered to be as safe and effective as the original drug. Generics tend to cost less than brand-name drugs. If you’re interested in using Zyprexa instead of olanzapine, talk with your doctor. They can tell yo...