Oxytocin indication

Dosage Forms & Strengths injectable solution • 10 units/mL Postpartum Hemorrhage 10 unit IM after delivery of placenta Add 10-40 units; not to exceed 40 units; to 1000 mL of nonhydrating IV solution and infuse at necessary rate to control uterine atony Labor Induction 0.5-1 mUnit/min IV, titrate 1-2 mUnit/min q15-60min until contraction pattern reached that is similiar to normal labor (usually 6 mUnits/min); may decrease dose after desired frequency of contraction reached and labor has progressed to 5-6 cm dilation Incomplete or Inevitable Abortion 10-20 mUnit/min; not to exceed 30 units/12 hr Monitor Intrauterine pressure, fetal heart rate Prader-Willi Syndrome (Orphan) Orphan designation for treatment of Prader-Willi syndrome Sponsor • Eric Hollander, MD; Montefiore Medical Center, Univ. Hosp for Albert Einstein College of Medicine; Bronx, New York 10467 • Pr Maithe Tauber; Hospital des enfants, TSA70034 31059; Toulouse, FRANCE Contraindicated (0) Serious - Use Alternative (6) • fexinidazole fexinidazole and oxytocin both increase QTc interval. Avoid or Use Alternate Drug. Avoid coadministration of fexinidazole with drugs known to block potassium channels or prolong QT interval. • isoflurane isoflurane and oxytocin both increase QTc interval. Avoid or Use Alternate Drug. • lefamulin lefamulin and oxytocin both increase QTc interval. Avoid or Use Alternate Drug. • mefloquine mefloquine increases toxicity of oxytocin by QTc interval. Avoid or Use Alternate Drug. Mefloquine...

Latest prescription information about Oxytocin. Learn how to pronounce the drug's name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, warnings and its storage instructions . Also listed are the International and Indian trade name(s) of the drug and its price list. This medication is a uterine stimulant, prescribed for the initiation of uterine contractions and induction of labor in women as well as stimulation of contractions in cases where the uterus does not contract enough during labor. It is also used to help abort the fetus in cases of incomplete abortion or miscarriage, and control bleeding after childbirth. It may be used for breast engorgement. This medication is contraindicated in cases where there is Cephalopelvic disproportion(CPD) (when a baby’s head or body is too large to fit through the mother’s pelvis); abnormal presentation of the fetus, excessive amniotic fluid; in women who have had multiple pregnancies, previous caesarian section or other uterine surgery; hyperactive or hypertonic uterus, uterine rupture; in cases where vaginal delivery is contraindicated (such as invasive cervical cancer, active genital herpes, prolapse of the cord, cord presentation or total placenta previa); fetal distress where delivery is not imminent; severe pre-eclamptic toxaemia (pregnancy induced high blood pressure). What is the dosage of Oxytocin? What are the warnings and precautions for Oxytocin? • Stop the drug imm...

Boxed Warning Appropriate use: Elective induction of labor is defined as the initiation of labor in a pregnant individual who has no medical indications for induction. Since the available data are inadequate to evaluate the benefits-to-risks considerations, oxytocin is not indicated for elective induction of labor. Dosage Forms Excipient information presented when available (limited, particularly for generics); consult specific product labeling. Solution, Injection: Pitocin: 10 units/mL (1 mL, 10 mL, 50 mL) [contains chlorobutanol (chlorobutol)] Generic: 10 units/mL (1 mL, 10 mL, 30 mL) Pharmacology Mechanism of Action Oxytocin stimulates uterine contraction by activating G-protein-coupled receptors that trigger increases in intracellular calcium levels in uterine myofibrils. Oxytocin also increases local prostaglandin production, further stimulating uterine contraction. Pharmacokinetics/Pharmacodynamics Excretion Urine (small amount unchanged) Onset of Action Uterine contractions: IM: 3 to 5 minutes; IV: ~1 minute Duration of Action IM: 2 to 3 hours; IV: 1 hour Half-Life Elimination 1 to 6 minutes; decreased in late pregnancy and during lactation Use: Labeled Indications Antepartum: Induction of labor in patients with a medical indication (eg, Rh problems, maternal diabetes, preeclampsia, at or near term); stimulation or reinforcement of labor (as in selected cases of uterine inertia); adjunctive therapy in management of incomplete or inevitable abortion Postpartum: To pr...

Applies to the following strengths: 10 units/mL; 30 units/500 mL-NaCl 0.9%; 30 units/500 mL-D5%LR; 30 units/500 mL-NaCl 0.45%; 20 units/1000 mL-0.9%; 30 units/500 mL-0.9%; 40 units/1000 mL-0.9%; 10 units/1000 mL-D5%LR; 20 units/1000 mL-D5%LR; 10 units/1000 mL-LR; 20 units/1000 mL-LR; 30 units/500 mL-LR; 10 units/1000 mL-0.9%; 10 units/500 mL-LR; 20 units/1000 mL-D5%; 30 units/500 mL-5%; 10 units/500 mL-5%; 20 units/500 mL-5%; 40 units/500 mL-5%; 10 units/1000 mL-D5%; 30 units/1000 mL-D5%; 40 units/1000 mL-D5%; 10 units/500 mL-0.9%; 20 units/500 mL-0.9%; 40 units/500 mL-0.9%; 30 units/1000 mL-0.9%; 10 units/500 mL-D5%LR; 20 units/500 mL-D5%LR; 40 units/500 mL-D5%LR; 20 units/500 mL-LR; 30 units/1000 mL-LR; 15 units/250 mL-LR; 60 units/1000 mL-NaCl 0.9%; 15 units/250 mL-D5%; 10 units/1000 mL-D5% with 0.45% NaCl; 20 units/1000 mL-D5% with 0.45% NaCl; 30 units/1000 mL-D5% with 0.45% NaCl; 15 units/250 mL-D5% with 0.225% NaCl; 30 units/1000 mL-D5%LR; 20 units/1000 mL-D5% with 0.9% NaCl; 30 units/500 mL-D5% with 0.9% NaCl; 5 units/500 mL-LR; 40 units/1000 mL-LR; 15 units/250 mL-NaCl 0.9% Usual Adult Dose for: • • • • Additional dosage information: • • • • • Usual Adult Dose for Labor Augmentation Initial dose: 0.5 to 1 milliunits/minute via IV infusion • Gradually increase dose in increments of 1 to 2 milliunits at 30 to 60 minute intervals until the desired contraction pattern has been established • Once desired frequency of contractions has been reached and labor has progresse...

Abnormal fetal position, cephalopelvic disproportion, cervical cancer, elective induction of labor, fetal distress, fetal prematurity, herpes infection, multiparity, placenta previa, requires a specialized care setting, requires an experienced clinician, surgery, vasa previa Use of oxytocin requires an experienced clinician who is trained in the administration and complications of the drug. Oxytocin use also requires a specialized care setting where intensive care and surgical facilities are immediately available. Furthermore, according to the manufacturer, oxytocin should only be used when induction of labor is necessary for medical reasons. It should not be used for elective induction of labor as available data are insufficient to evaluate the risk-benefit ratio in this indication. When oxytocin is used for induction or reinforcement of already existent labor, patients should be carefully selected. Pelvic adequacy must be considered and maternal and fetal conditions evaluated prior to initiation. The use of oxytocin is contraindicated in the following circumstances: where there is significant cephalopelvic disproportion, in unfavorable fetal positions or presentations which are undeliverable without conversion prior to delivery (i.e., transverse lies), in obstetrical emergencies where the benefit-to-risk ratio for either the fetus or the mother favors surgical intervention, in fetal distress where delivery is not imminent, where adequate uterine activity fails to achieve...