P lcr in blood test

  1. Mean Platelet Volume (MPV)
  2. Platelet Distribution Width (PDW)
  3. MPV Blood Test: Procedure, Results, and Causes


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Mean Platelet Volume (MPV)

Mean platelet volume is a test that measures and calculates the average size of the platelets. Platelets, also called thrombocytes, are one of three types of cells found in the blood. Their primary function, along with the coagulation factors, is to stop bleeding by clumping and clotting blood vessel injuries. High MPVs mean the platelets are larger, which could put an individual at risk for heart attack or stroke. Low MPVs indicate smaller platelets, meaning the individual is at risk for a bleeding disorder. Typically, the results of a MPV test are compared to the platelet count and the platelet distribution width (PDW) to provide a doctor with more information regarding the underlying condition. Assessment of platelets is typically done in a comprehensive blood count (CBC), which also measures features of red and white blood cells. The CBC is a very common test. A healthcare professional may run a CBC as a part of a routine health examination or when a person has signs and symptoms that may be related to disorders that affect blood cells, such as: - Infection - Inflammation - Bruising - Excessive bleeding If someone has been diagnosed with a disease that is known to affect blood cells, a CBC will be ordered regularly to monitor the condition. Similarly, if someone is receiving treatment for a blood-related disorder, a CBC will be ordered regularly to determine if the treatment is effective. Further, some therapies (e.g., chemotherapy) can affect production of blood cells...

Platelet Distribution Width (PDW)

What is Platelet distribution width (PDW)? Platelet distribution width (PDW) reflects variability in platelet size, and is considered a marker of platelet function and activation. What is the function of platelets? Platelets play an important role in the processes of coagulation, inflammation, and immune response. Why is this marker useful? This marker can give you additional information about your platelets and the cause of a high or low platelet count. Larger platelets are usually younger platelets that have been released earlier than normal from the bone marrow, while smaller platelets may be older and have been in circulation for a few days. PDW reflects how uniform the platelets are in size. A normal PDW indicates platelets that are mostly the same size, while a high PDW means that platelet size varies greatly, a clue that there is platelet activation and has been associated with vascular diseases and certain cancers. Sometimes during the test, platelets stick together and the machine gives a false reading, interpreting it as fewer, larger platelets. In that case, the lab may do a blood smear and directly examine the platelets under a microscope. Higher MPV and PDW levels may be associated with inflammation and thyroid malignancies. References: - https://www.tandfonline.com/doi/full/10.1080/20009666.2019. - https://www.endocrine-abstracts.org/ea/0041/ea0041ep968

MPV Blood Test: Procedure, Results, and Causes

• Platelet size: The size of your platelets indicates how old they are. The cells are bigger when they first come out of the bone marrow, where they are produced. Smaller platelets are usually older. • How active these cells are: Platelets that are not functioning as they should interfere with hemostasis (stopping of blood flow) and thrombosis (clotting). • Low platelet count and high MPVoccurs when platelets are destroyed, usually by antibodies, an infection, or toxins. For example, • High platelet count and high MPVcan occur when the bone marrow makes too many platelets, typically due to a genetic mutation or cancer. • Normal platelet count and high MPVsuggests conditions such as hyperthyroidism or • People who live at low altitudes (below sea level) may have higher than average platelet counts. Those who live at high altitudes may have a high MPV, which may be a possible risk factor for heart disease. • Smoking and high glucose levels (without a diagnosis of diabetes) have all been associated with a high MPV in men. • Menstruation and oral contraceptives are associated with high MPV in women. • Certain medications, such as • MedlinePlus. • Icli A, Tayyar S, Varol E, et al. Med Princ Pract. 2013;22(3):270–273. doi:10.1159/000345393 • Yan K, Ding B, Huang J, Dai Y, Xiong S, Zhai Z. Oncol Lett. 2015;10(4):2390–2394. doi:10.3892/ol.2015.3502 • Schmoeller D, Picarelli MM, Paz Munhoz T, Poli de Figueiredo CE, Staub HL. Front Med (Lausanne). 2017;4:146. doi:10.3389/fmed.2017.0...

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