Romiplostim injection

Nplate ® is a thrombopoietin receptor agonist indicated for the treatment of thrombocytopenia in adult patients with immune thrombocytopenia (ITP) who have had an insufficient response to corticosteroids, immunoglobulins, or splenectomy. Nplate ® is indicated for the treatment of thrombocytopenia in pediatric patients 1 year of age and older with ITP for at least 6 months who have had an insufficient response to corticosteroids, immunoglobulins, or splenectomy. Nplate ® is not indicated for the treatment of thrombocytopenia due to myelodysplastic syndrome (MDS) or any cause of thrombocytopenia other than ITP. Nplate ® should be used only in patients with ITP whose degree of thrombocytopenia and clinical condition increase the risk for bleeding. Nplate ® should not be used in an attempt to normalize platelet counts. ... ReadMore Nplate ® dosing calculator 4 easy steps to calculate your patient's total Nplate ® injection volume 1 This tool provides calculation assistance only. It is not designed or intended to replace the physician’s clinical judgment in determining the appropriate dose for his or her patient. • Adult patients: Actual body weight at initiation of therapy should always be used when calculating the dose. • Pediatric patients: Base future dose adjustments on changes in platelet counts and body weight (reassessment of body weight every 12 weeks is recommended). 1 Individualize ITP treatment with Nplate ® Tips for dosing success • The initial dose for Nplate ® is...

(roe mi PLOE stim) Trade Name: Nplate TM Romiplostimis the generic name for the trade name drug Nplate. In some cases, health care professionals may use the trade name Nplate when referring to the generic drug name Romiplostim. Drug Type: Romiplostim is a biologic response modifier. It is classified as a colony stimulating factor. (For more detail, see "How this drug works" section below). What Romiplostim Is Used For: • Romiplostim is used for the treatment of thrombocytopenia (low platelets) in patients with chronic immune (idiopathic) thrombocytopenia purpura (ITP) who have had insufficient response to corticosteroids, immune globulin, or splenectomy. • Nplate is not indicated to normalize platelet counts. Note: If a drug has been approved for one use, physicians may elect to use this same drug for other problems if they believe it may be helpful. However, Romiplostim is administered through the NEXUS program, which requires monitoring of the efficacy and use of Romiplostim on a periodic basis. NEXUS will also determine if the cost of Romiplostim is covered by insurers, and it may not be for uses outside of the approved indication (ITP) How Romiplostim Is Given: • Romiplostim may be given by subcutaneous (the layer between the skin and muscle) injection. • The amount of Romiplostim that you will receive depends on many factors, including your height and weight, and your general health or other health problems. Your doctor will determine your exact dosage and schedule. S...

Romiplostim helps your body make more platelets. These are the smallest component of your blood that control bleeding. This medication treats chronic idiopathic thrombocytopenic purpura. This is a blood condition that occurs when you don’t have enough platelets. A healthcare provider will give you this injection in a hospital or clinic setting. What is this medication? ROMIPLOSTIM (roe mi PLOE stim) helps your body make more platelets. This medicine is used to treat low platelets caused by chronic idiopathic thrombocytopenic purpura (ITP) or a bone marrow syndrome caused by radiation sickness. This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions. COMMON BRAND NAME(S): Nplate What should I tell my care team before I take this medication? They need to know if you have any of these conditions: • blood clots • myelodysplastic syndrome • an unusual or allergic reaction to romiplostim, mannitol, other medicines, foods, dyes, or preservatives • pregnant or trying to get pregnant • breast-feeding How should I use this medication? This medicine is injected under the skin. It is given by a health care provider in a hospital or clinic setting. A special MedGuide will be given to you before each treatment. Be sure to read this information carefully each time. Talk to your health care provider about the use of this medicine in children. While it may be prescribed for children as young as newborns for selected conditions, precau...

What Is Nplate? Nplate (romiplostim) is an Fc-peptide fusion protein (peptibody), a man-made form of a protein that increases production of platelets (blood-clotting cells) in the body, used to prevent bleeding episodes in people with chronic immune thrombocytopenic purpura (ITP), a bleeding condition caused by a lack of platelets in the blood. Nplate is usually given after other medications have been tried without successful treatment of symptoms. What Are Side Effects of Nplate? Common side effects of Nplate include: • headache, • joint or muscle pain, • dizziness, • heartburn, • abdominal pain, • stomach upset, • tingling or numbness in hands or feet, • trouble sleeping (insomnia), or • pain in your arms/legs/shoulder Dosage for Nplate The initial dose for Nplate is 1 mcg/kg based on actual body weight. What Drugs, Substances, or Supplements Interact with Nplate? Other drugs may interact with Nplate. Tell your doctor all medications and supplements you use. Nplate and Pregnancy During pregnancy, Nplate should be used only when prescribed. It is unknown if this drug passes into breast milk. Consult your doctor before breastfeeding. Additional Information Our Nplate (romiplostim) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication. Find Lowest Prices on You may also report side effects to Amgen at 1-800-77-AMGEN (1-800-772-6436). DESCRIPTION Romiplostim, a member of the TPO Escheric...

Dosage Forms & Strengths injection, lyophilized powder for reconstitution • 125mcg/vial • 250mcg/vial • 500mcg/vial Chronic Immune Thrombocytopenia (ITP) Indicated for immune thrombocytopenia (ITP) who have had an insufficient response to corticosteroids, immunoglobulins, or splenectomy Initial • 1 mcg/kg SC qWeek • Use lowest dose of Nplate to achieve and maintain a platelet count ≥50 x 10 9/L as necessary to reduce the risk for bleeding Dose adjustment • Adjust weekly dose by increments of 1 mcg/kg until platelet count ≥50 x 109/L as necessary to reduce the risk for bleeding; not to exceed maximum weekly dose of 10 mcg/kg • Median dose of 2 mcg/kg in clinical studies Determine dose adjustment by platelet count • Platelets 200 to ≤400 x 10 9/L for 2 consecutive weeks: Reduce by 1 mcg/kg • Platelet >400 x 10 9/L: Do not give dose; continue weekly platelet assessment, if platelets fall to 2 gray (Gy) Dosage Modifications Renal or hepatic impairment: Not studied Dosing Considerations Limitations of use • Not indicated for thrombocytopenia due to myelodysplastic syndrome (MDS) or any cause of thrombocytopenia other than chronic ITP • Only use in patients with ITP whose degree of thrombocytopenia and clinical condition increases the risk for bleeding • Do not use as an attempt to normalize platelet counts Monitoring parameters • CBC, including platelet counts • During treatment: Obtain weekly during dose adjustment phase, and then monthly once stable dose established • Discont...