This medication comes in extended-release tablet form and is taken once a day, in the morning with food. Do not chew, divide, or break dapagliflozin/metformin tablets. Swallow tablets whole. Common side effects of dapagliflozin/metformin include yeast infection in females, a cold, urinary tract infection, diarrhea, and headache.

Dapagliflozin is a sodium-glucose co-transporter-2 (SGLT-2) inhibitor and works by removing sugar from the body with the urine. It was developed by Bristol-Myers Squibb in partnership with AstraZeneca. It is on the World Health Organization's List of Essential Medicines.

In rats, dapagliflozin was neither embryolethal nor teratogenic at doses up to 75 mg/kg/day (1441-times the 10 mg clinical dose, based on AUC). Dose related effects on the rat fetus (structural abnormalities and reduced body weight) occurred only at higher dosages, equal to or greater than 150 mg/kg (more than 2344-times the 10 mg clinical dose.

Adults—At first, 1 tablet once a day, taken in the morning. Each tablet contains 5 milligrams (mg) dapagliflozin, 5 mg saxagliptin, and 1000 mg or 2000 mg metformin. Your doctor may adjust your dose as needed and tolerated. However, the dose is usually not more than 10 mg dapagliflozin, 5 mg saxagliptin, and 2000 mg metformin per day.

Farxiga (dapagliflozin) is a brand-name prescription drug used for type 2 diabetes, heart failure, and other conditions.. Metformin is also available as a solution that is taken by mouth. Side.

XIGDUO® XR (dapagliflozin and metformin hydrochloride extended-release) Jump To Highlights of Prescribing Information