Dapagliflozin metformin

Usual Adult Dose for: • Additional dosage information: • • • • • • Usual Adult Dose for Diabetes Type 2 To Improve Glycemic Control for For Patients Not Already Taking Dapagliflozin: • Initial dose: dapagliflozin 5 mg plus current metformin dose orally once a day To Reduce Risk of Hospitalization for Heart Failure: • Initial dose: dapagliflozin 10 mg plus current metformin dose orally once a day Adjust doses based on effectiveness and tolerability Maximum dose: Dapagliflozin 10 mg-metformin 2000 mg per day Comments: • Patients taking an evening dose of metformin XR should skip their last dose before starting this drug; take this drug once daily in the morning with food. • When used in combination with insulin or insulin secretagogue, a lower dose of with insulin or insulin secretagogue may be considered to reduce the risk of hypoglycemia. Uses: • As an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus. • Dapagliflozin is indicated to reduce the risk of hospitalization for heart failure in patients with type 2 diabetes mellitus and established cardiovascular disease or multiple cardiovascular risk factors. Renal Dose Adjustments eGFR 45 mL/min/1.73 m2 or greater: No adjustment recommended eGFR 30 to less than 45 mL/min/1.73 m2: Not recommended eGFR less than 30 mL/min/1.73 m2: Contraindicated Liver Dose Adjustments Not recommended in patients with hepatic impairment Dose Adjustments Therapeutic drug monitoring/range: Steady-sta...

This medicine should come with a Medication Guide. Read and follow these instructions carefully. Ask your doctor if you have any questions. Take this medicine in the morning with food. Swallow the extended-release tablet whole. Do not crush, break, or chew it. While taking the extended-release tablet, part of it may pass into your stools. This is normal and is nothing to worry about. Carefully follow the special meal plan your doctor gave you. This is the most important part of controlling your diabetes, and will help the medicine work properly. Exercise regularly and test for sugar in your blood or urine as directed. Tell your doctor if you are on a low-salt or sodium diet. Dosing The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so. The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine. • For oral dosage form (extended-release tablets): • For type 2 diabetes: • Adults—At first, 5 milligrams (mg) once a day. Your doctor may adjust your dose as needed and tolerated. However, the dose is usually not more than dapagliflozin 10 mg and met...

Oral route(Tablet, Extended Release) Fatal metformin-associated lactic acidosis has been reported during postmarketing surveillance. The onset is often subtle and subtle and accompanied only by nonspecific symptoms (eg, malaise, myalgias, respiratory distress, somnolence, abdominal pain). Risk factors include concomitant carbonic anhydrase inhibitor use (eg, topiramate), age 65 or older, surgery and other procedures, radiological study with contrast, hypoxic states, excessive alcohol consumption, or hepatic impairment. If suspected, discontinue use and initiate hemodialysis and general supportive measures . Uses for dapagliflozin and metformin Dapagliflozin and metformin combination is used together with proper diet and exercise to treat type 2 diabetes. It is also used to lower the risk of hospitalization for heart failure in patients with type 2 diabetes and cardiovascular (heart or blood vessel) disease or multiple cardiovascular risk factors. This medicine is also used to lower the risk of cardiovascular death and hospitalization in patients with heart failure with reduced ejection fraction (the heart is weak and cannot pump enough blood to the rest of the body. Dapagliflozin and metformin combination is also used to lower the risk of worsening of kidney disease, end stage kidney disease, cardiovascular death, and hospitalization for heart failure in patients with chronic kidney disease. Dapagliflozin works in the kidneys to prevent absorption of glucose (blood sugar)....

Key:JVHXJTBJCFBINQ-ADAARDCZSA-N Y Dapagliflozin, sold under the brand names Farxiga (US) and Forxiga (EU) among others, is a medication used to treat Common side effects include It was developed by million prescriptions. Medical uses [ ] Dapagliflozin is used along with diet, exercise, and usually with other glucose lowering medications, to improve glycaemic control in adults with type 2 diabetes and to reduce the risk of hospitalization for heart failure among adults with type 2 diabetes and known cardiovascular disease or other cardiovascular risk factors (including high blood pressure, high cholesterol, and smokers). Dapagliflozin, in addition to other SGLT2-inhibitors, was shown to reduce the rate of decline in kidney function and kidney failure in non-diabetic and type 2 diabetic adults. In addition, dapagliflozin is indicated for the treatment of adults with heart failure with reduced ejection fraction to reduce the risk of cardiovascular death and hospitalization for heart failure. In the European Union it is indicated in adults: • For the treatment of insufficiently controlled type 2 diabetes mellitus as an adjunct to diet and exercise: • as monotherapy when • in addition to other medicinal products for the treatment of type 2 diabetes; • For the treatment of heart failure with reduced ejection fraction In November 2021, the Effects in nondiabetic chronic kidney disease [ ] In 2021, the US Dapagliflozin was found to have no effect on proteins in the urine in non-di...

Serious allergic reactions may occur with this medicine. Check with your doctor right away if you have a skin rash, hives or welts, itching, redness of the skin, trouble breathing, or large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or genitals. Using this medicine during the second and third part of your pregnancy can harm your unborn baby. If you think you have become pregnant while using this medicine, tell your doctor right away. This medicine may cause some women who do not have regular monthly periods to ovulate. This can increase the chance of pregnancy. If you are a woman of childbearing potential, you should discuss birth control options with your doctor. It is very important to follow carefully any instructions from your doctor about: • Alcohol—Drinking alcohol may cause severe low blood sugar and increase risk for lactic acidosis. Discuss this with your doctor. • Other medicines—Do not take other medicines unless they have been discussed with your doctor. This especially includes nonprescription medicines such as aspirin, and medicines for appetite control, asthma, colds, cough, hay fever, or sinus problems. • Counseling—Other family members need to learn how to prevent side effects or help with side effects if they occur. Also, patients with diabetes may need special counseling about diabetes medicine dosing changes that might occur because of lifestyle changes, such as changes in exercise and diet. Furthermore, counselin...

Serious allergic reactions may occur with this medicine. Check with your doctor right away if you have a skin rash, hives or welts, itching, redness of the skin, trouble breathing, or large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or genitals. Using this medicine during the second and third part of your pregnancy can harm your unborn baby. If you think you have become pregnant while using this medicine, tell your doctor right away. This medicine may cause some women who do not have regular monthly periods to ovulate. This can increase the chance of pregnancy. If you are a woman of childbearing potential, you should discuss birth control options with your doctor. It is very important to follow carefully any instructions from your doctor about: • Alcohol—Drinking alcohol may cause severe low blood sugar and increase risk for lactic acidosis. Discuss this with your doctor. • Other medicines—Do not take other medicines unless they have been discussed with your doctor. This especially includes nonprescription medicines such as aspirin, and medicines for appetite control, asthma, colds, cough, hay fever, or sinus problems. • Counseling—Other family members need to learn how to prevent side effects or help with side effects if they occur. Also, patients with diabetes may need special counseling about diabetes medicine dosing changes that might occur because of lifestyle changes, such as changes in exercise and diet. Furthermore, counselin...

Key:JVHXJTBJCFBINQ-ADAARDCZSA-N Y Dapagliflozin, sold under the brand names Farxiga (US) and Forxiga (EU) among others, is a medication used to treat Common side effects include It was developed by million prescriptions. Medical uses [ ] Dapagliflozin is used along with diet, exercise, and usually with other glucose lowering medications, to improve glycaemic control in adults with type 2 diabetes and to reduce the risk of hospitalization for heart failure among adults with type 2 diabetes and known cardiovascular disease or other cardiovascular risk factors (including high blood pressure, high cholesterol, and smokers). Dapagliflozin, in addition to other SGLT2-inhibitors, was shown to reduce the rate of decline in kidney function and kidney failure in non-diabetic and type 2 diabetic adults. In addition, dapagliflozin is indicated for the treatment of adults with heart failure with reduced ejection fraction to reduce the risk of cardiovascular death and hospitalization for heart failure. In the European Union it is indicated in adults: • For the treatment of insufficiently controlled type 2 diabetes mellitus as an adjunct to diet and exercise: • as monotherapy when • in addition to other medicinal products for the treatment of type 2 diabetes; • For the treatment of heart failure with reduced ejection fraction In November 2021, the Effects in nondiabetic chronic kidney disease [ ] In 2021, the US Dapagliflozin was found to have no effect on proteins in the urine in non-di...

This medicine should come with a Medication Guide. Read and follow these instructions carefully. Ask your doctor if you have any questions. Take this medicine in the morning with food. Swallow the extended-release tablet whole. Do not crush, break, or chew it. While taking the extended-release tablet, part of it may pass into your stools. This is normal and is nothing to worry about. Carefully follow the special meal plan your doctor gave you. This is the most important part of controlling your diabetes, and will help the medicine work properly. Exercise regularly and test for sugar in your blood or urine as directed. Tell your doctor if you are on a low-salt or sodium diet. Dosing The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so. The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine. • For oral dosage form (extended-release tablets): • For type 2 diabetes: • Adults—At first, 5 milligrams (mg) once a day. Your doctor may adjust your dose as needed and tolerated. However, the dose is usually not more than dapagliflozin 10 mg and met...

Usual Adult Dose for: • Additional dosage information: • • • • • • Usual Adult Dose for Diabetes Type 2 To Improve Glycemic Control for For Patients Not Already Taking Dapagliflozin: • Initial dose: dapagliflozin 5 mg plus current metformin dose orally once a day To Reduce Risk of Hospitalization for Heart Failure: • Initial dose: dapagliflozin 10 mg plus current metformin dose orally once a day Adjust doses based on effectiveness and tolerability Maximum dose: Dapagliflozin 10 mg-metformin 2000 mg per day Comments: • Patients taking an evening dose of metformin XR should skip their last dose before starting this drug; take this drug once daily in the morning with food. • When used in combination with insulin or insulin secretagogue, a lower dose of with insulin or insulin secretagogue may be considered to reduce the risk of hypoglycemia. Uses: • As an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus. • Dapagliflozin is indicated to reduce the risk of hospitalization for heart failure in patients with type 2 diabetes mellitus and established cardiovascular disease or multiple cardiovascular risk factors. Renal Dose Adjustments eGFR 45 mL/min/1.73 m2 or greater: No adjustment recommended eGFR 30 to less than 45 mL/min/1.73 m2: Not recommended eGFR less than 30 mL/min/1.73 m2: Contraindicated Liver Dose Adjustments Not recommended in patients with hepatic impairment Dose Adjustments Therapeutic drug monitoring/range: Steady-sta...

Oral route(Tablet, Extended Release) Fatal metformin-associated lactic acidosis has been reported during postmarketing surveillance. The onset is often subtle and subtle and accompanied only by nonspecific symptoms (eg, malaise, myalgias, respiratory distress, somnolence, abdominal pain). Risk factors include concomitant carbonic anhydrase inhibitor use (eg, topiramate), age 65 or older, surgery and other procedures, radiological study with contrast, hypoxic states, excessive alcohol consumption, or hepatic impairment. If suspected, discontinue use and initiate hemodialysis and general supportive measures . Uses for dapagliflozin and metformin Dapagliflozin and metformin combination is used together with proper diet and exercise to treat type 2 diabetes. It is also used to lower the risk of hospitalization for heart failure in patients with type 2 diabetes and cardiovascular (heart or blood vessel) disease or multiple cardiovascular risk factors. This medicine is also used to lower the risk of cardiovascular death and hospitalization in patients with heart failure with reduced ejection fraction (the heart is weak and cannot pump enough blood to the rest of the body. Dapagliflozin and metformin combination is also used to lower the risk of worsening of kidney disease, end stage kidney disease, cardiovascular death, and hospitalization for heart failure in patients with chronic kidney disease. Dapagliflozin works in the kidneys to prevent absorption of glucose (blood sugar)....