More than 50 years ago, Victor Herbert first described the concept that defective nucleoprotein synthesis, attributable to various causes, results in the development of megaloblastic anemia. 1.

Some common causes of folic acid megaloblastic anemia are: alcohol use disorder. pregnancy. Crohn’s disease. celiac disease. small bowel resection. Animal products, including seafood, beef, chicken, eggs, and dairy, are the primary source of vitamin B12. Although a vegan diet that is not well-planned can cause vitamin B12 deficiency.

Megaloblastic anemia is a condition where there are abnormally large red blood cells. Learn about the causes, symptoms, diagnosis, and treatment of this condition, and how to prevent it by eating food rich in vitamin B12. Consult a doctor if you experience any symptoms.

a condition in which there is reduced delivery of oxygen to the tissues; it is not actually a disease but rather a symptom of any of numerous different disorders and other conditions. The World Health Organization has defined anemia as a hemoglobin concentration below 7.5 mmol/L (12 g/dL) in women and below 8.1 mmol/L (13 g/dL) in men.

Megaloblastic Anemias. 3.2.6. Megaloblastic anemia is caused by either a vitamin B-12 deficiency or a folic acid deficiency that results in impaired DNA synthesis and consequently enlarged red blood cells. These unusually large and structurally abnormal immature red blood cells are called megaloblasts, hence the name of this condition.

Causes Diagnosis Treatment Megaloblastic anemia is a type of blood cell deficiency with larger than normal red blood cells and enlarged and abnormal red blood cell precursors (megaloblasts) in the bone marrow. This type of anemia often develops due to vitamin B12 (cobalamin) deficiency or vitamin B9 (folate) deficiency.

The main cause of megaloblastic anemias is deficiency of either cobalamin (vitamin B 12) or folic acid, vitamins that are essential for DNA replication and repair. In addition, chemotherapeutic drugs that inhibit DNA synthesis can result in findings similar to those seen in cobalamin or folate deficiency.